Association of endothelial nitric oxide synthase promoter region (T-786C) gene polymorphism with acute coronary syndrome and coronary heart disease

İstanbul Bilim Üniversitesi, Tıp Fakültesi.Background Nitric oxide (NO) is an endothelium derived relaxing factor (EDRF) which has an important role for regulating the heart-vessel physiology. The objective of this study was to evaluate the effects of the eNOS T-786C polymorphism on lipid parameters and the development of acute coronary syndrome (ACS) and coronary heart disease (CHD) for the first time in a Turkish study group. We have analyzed the genotype frequencies of the T-786C polymorphism of the eNOS gene in 10 ACS patients (5 men, 5 women), 20 CHD patients (14 men, 6 women), and 31 controls (10 men, 21 women), who were angiographically proven to have normal coronaries. Results The demographic, biochemical and left ventricule systolic dysfunction data of the ACS, CHD patients and controls were analyzed as a function of eNOS T-786C genotypes. The eNOS gene T-786C polymorphism frequencies for T/T, C/T and C/C genotypes were respectively 10%, 40%, 50% in subjects with ACS; 75%, 20%, 5% in subjects with CHD and 67.7%, 25.8%, 6.5% in the control group. Significant difference was observed in genotype frequencies between the study groups for T-786C polymorphism (p = 0.001). The CC genotype frequency was found to be the most prevalent in ACS group in comparison to CHD and control groups (p = 0.001). TT was the most frequently observed genotype in both CHD patients and controls (p = 0.001). Left ventricule systolic dysfunction frequency was found to be highest in C/T genotype carriers (66.7%) in patients (ACS+CHD). None of the patients with LVSD were carrying the normal genotype (T/T). The eNOS T-786C polymorphism was not found to be effective over any analyzed lipid variable in patients (ACS+CHD). The HDL-cholesterol levels were found to be lower in CHD group were compared to controls (p < 0.01), whereas glucose and leucocyte levels of the ACS and CHD groups were both higher than controls (p < 0.001). Conclusion The significantly high frequency of eNOS -786C/C genotype in ACS patients than in those of controls, indicate the genotype association with ACS. The finding of significantly high frequency of T/T genotype in the CHD group, may support the relationship of CC genotype with ACS without CHD. The high frequency of the mutant (C/C) and heterozygous (C/T) genotypes found may be linked to left ventricule remodeling after MI

Collaborative dynamic decision making: a case study from B2B supplier selection

The problem of supplier selection can be easily modeled as a multiple-criteria decision making (MCDM) problem: businesses express their preferences with respect to suppliers, which can then be ranked and selected. This approach has two major pitfalls: first, it does not consider a dynamic scenario, in which suppliers and their ratings are constantly changing; second, it only addressed the problem from the point of view of a single business, and cannot be easily applied when considering more than one business. To overcome these problems, we introduce a method for supplier selection that builds upon the dynamic MCDM framework of Campanella and Ribeiro [1] and, by means of a linear programming model, can be used in the case of multiple collaborating businesses plan- ning their next batch of orders together.Fundação para a Ciência e a Tecnologia, Portugal, under contract CONT DOUT/49/UNINOVA/0/5902/1/200

Economic, social and ecological impacts of bioenergy at local, national and global levels

The inevitable transition to a decarbonized society necessitates a widespread utilization of bio-based materials and technologies toward mitigating climate change. In accordance with the European Union's sustainable development strategies, the integration of bioenergy to the existing energy mix is essential for the valorization of energy resources. In this chapter, processes and products contributing to bioenergy are reviewed within the context of biorefinery approach. Economic, ecological, and social impacts of bioenergy are discussed with examples from around the globe. Finally, suggestions to promote and sustain the implementation of bioenergy within the scope of circular bioeconomy are proposed. © 2023 Elsevier Ltd. All rights reserved

Rethinking LGBTI+ health through reflections on web-based research

Objective: Although 5 to 10% of the world's population is estimated to consist of lesbian, gay, bisexual, transgender, intersex and individuals with other minority sexual orientations (LGBTI+), they still face significant challenges accessing health care. With this web-based study, we aim to present data on their health status and shed light on the difficulties that LGBTI+ populations living in Turkey face in accessing healthcare services. Method: This descriptive study was prepared as a web-based questionnaire to collect information on demographic attributes and healthcare specific challenges LGBTI+ communities experience. The questionnaire was disseminated via different social media networks. 278 LGBTI+ individuals met the eligibility criteria and were included in the study. The data was analysed using the SPSS software package. Results: The prevalence of chronic diseases, mental disorders, alcohol use, smoking and substance abuse in the survey was found to be higher than average in the LGBT+ community. Of the respondents, 67.3% stated that they did not disclose their sexual orientation and gender identity to health professionals. 25.2% of the respondents had experienced discrimination or similar unpleasant attitudes within institutions, a majority of which were state hospitals, when they disclosed their sexual orientation or gender identities. Of these attitudes, 20,9% reported direct discrimination from physicians and 92.8% of the respondents indicated the need for LGBTI-friendly health institutions. Conclusions: The findings of this research highlight the need for LGBTI+-friendly health institutions to fight against discrimination and serve as a tool for health promotion. Intensified involvement of public health professionals in these issues is needed

Fuzzy AHP–GOAL Programming Approach for a Supplier Selection Problem

This paper presents an integrated evaluation approach for decision support enabling effective supplier selection and ordering processes in textile industry. The integrated evaluation method in this study includes two phases that consist of fuzzy AHP and goal programming approaches. Supplier evaluation and selection is a multi-criterion decision problem which includes both qualitative and quantitative factors. That’s why; firstly, linguistic variables expressed in trapezoidal fuzzy numbers are applied to assess weights and ratings of supplier selection criteria. Then a hierarchy multiple model based on fuzzy set theory is expressed and the geometric mean method of Buckley is used to aggregate pair wise comparisons. Finally, a goal programming model is built using the goals about coefficients of suppliers, total ordering cost, number of wrong deliveries, total delivery cost under the constraints of required minimum and maximum number of orderings and acceptable quality cost levels of each supplier and demand constraint of the product

Sleep quality and immune functions in rheumatoid arthritis patients with and without major depression

PubMedID: 14702212The purpose of this study was to determine the discriminative factors between rheumatoid arthritis (RA) patients with and without major depression (MD). We assessed subjective sleep quality, pain, and cell-mediated immune functions in RA patients with (n = 20) and without (n = 20) MD by using Pittsburgh Sleep Quality Index (PSQI), visual analogue scale (VAS), and fluorescein isothiocyanat (FITC) labeled CD3, CD4, CD8, CD19, CD45, CD56, and HLADR T monoclonal antibodies by flow cytometry. We found that the RA patients with MD had significantly higher pain level, poorer sleep quality, higher HDRS points, and higher HLADR T cell level than those without MD; and that these variables are discriminant factors between patient groups. These findings suggest that the RA patients with MD may be differentiated from those without MD by using VAS, PSQ1, and HLADR levels; that these variables correctly classify the depressed and nondepressed groups up to an accuracy level of 96.8%

22.5 MB deletion of 13q31.1-q34 associated with HPE, DWM, and HSCR: A case report and redefining the smallest deleted regions

22.5 MB deletion ofliqil. l-qi4 associated with HPE, DWM, and HSCR: A case report and redefining the smallest deleted regions: Partial deletion of the long arm of the chromosome 13, 13q deletion syndrome is a rare chromosomal disorder characterized by severe growth and mental retardation, microcephaly, facial dysmorphism, hrain malformations (holoprosencephaly, Dandy-Walker malformation), distal limb defects, eye anomalies, genitourinary and gastrointestinal tract malformations (Hirschsprung's disease). Approximately 1.2 Mb region in 3q32 was suggested as minimal critical region which is responsible for severe mental and growth retardation and brain anomalies. Here we described a male patient with de novo interstitial deletion of I3q31.1-q34 associated with short stature, microcephaly, facial dysmorphism, clinodactyly, cryptorchidism, micropenis, epilepsy, HI'H, DWM, and HSCR. According to the literature review, present case indicated that smallest deleted region associated with DWM HPE might be located at the 13q32.3, limb defects 13q34, anogenital malformations 13q33.3-34, and HSCR 13q3l.1-32.1