Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity.

Background Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity

Clinical and demographic features of hidradenitis suppurativa: A multicentre study of 1221 patients with an analysis of risk factors associated with disease severity

Background Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity. Aim In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity. Methods In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed. Results The mean age of disease onset was 26.2 +/- 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 +/- 8.4 years with a delay in diagnosis of 5.8 +/- 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years. Conclusions Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity

Synthetic Seed Production of Flower Bulbs

WOS: 000558565200013Flower bulbs are perennial or annual plants with underground structures such as bulb, corn, tuber, and rhizomes. These plants have economic value especially in ornamental plant sector as cut flower, potted flower, and outdoor plants. Most of these plants have garish flower, and many of them are monocotyledon. Cyclamen, Tulipa, Lilium, Narcissus, Gladiolus, Hyacinthus, Crocus, Iris, Allium, Alstroemeria, Anemone, Orchis, Rhododendron, Freesia, Hippeastrum, Muscari, Ornithogalum, Ranunculus, and Zantedeschia are the most important geophytes that are commercially used in the world. These plants can be propagated using conventional and tissue culture techniques. Synthetic seed production is one of these techniques. Synthetic seed, namely, artificial seed, is described as artificially encapsulated plant tissues and somatic embryos with alginate hydrogel. Synthetic seed technology has significant effect on the conservation of the plant tissues and sustainability of the plants. Recently, conservation of the plant species studies significantly increased, and artificial seed method was used as the most common process to conserve important species. in this chapter, oldest and newest synthetic seed production researches were discussed and presented chronologically