Implementation of 5G Telecommunication Network Services in Indonesia based on Techno-economic Analysis

The 2300 MHz spectrum is a medium band that telco operators will not pay much attention to when they deploy 5G. They are more comfortable at 2.6 GHz, 3.5 GHz, 26 GHz, and 28 GHz, in addition to 700 MHz for the breadth of coverage. The performance of cellular telecommunications services based on 5G technology is possible for new operators, although it will be carried out as stand-alone services. This opportunity will be taken by looking at internet subscriber data/data communication from existing operators as active internet users, which is quite large and has a potential of over 250 million users. There has been no previous study regarding the feasibility of deploying this 5G technology-based Broadband Wireless Access (BWA) Network. Based on the experience of implementing previous generations of telecommunication service technology, the government and operators need to be careful in determining the right moment to deploy this 5G technology service, which is predicted to be able to provide broadband services with streaming capabilities of 10 to 100 times the streaming speed of 4G technology. It should be noted that the lack of success of 3G performances in 2006 from 2G, 2.5G, and 2.75 G. Almost all operators who were expected to be very lucky turned out to be not optimal; even now, only 4 operators are playing on 3G. where they have not been able to force users of the 2G generation to switch to 3G, including in big cities where the performance of the 3G network is not yet optimal and evenly distributed. Still, many areas are blank spots from 3G networks and services. From this experience, scientific studies are needed to ensure the feasibility of the upcoming 5G BWA business and identify business opportunities that can be implemented. The feasibility analysis must be viewed from various aspects, namely aspects of technical readiness, market aspects, and financial aspects in terms of the techno-economics of the operators who will provide 5G telecommunications services by calculating several essential parameters as a measure of business feasibility, namely Net Present Value (NPV), Internal Rate of Return (IRR), and Payback Period (PBP)

APLIKASI GAME EDUKASI TEKA TEKI SILANG DIGITAL GLOSARIUM TIK DI BIDANG PEMROGRAMAN BERBASIS MOBILE ANDROID

Tujuan dari penelitian ini adalah untuk menambah ilmu pengetahuan user yang menggunakan aplikasi ini terhadap istilah teknologi dan komputer khususnya di bidang pemrograman dengan mengembangkan aplikasi game edukasi teka teki silang glosarium teknologi dan komputer berbasis mobile android. Metode Pengembangan aplikasi ini menggunakan Metode Waterfall. Pengembangan aplikasi ini telah melalui beberapa tahap evaluasi ahli materi, ahli media dan uji responden. Berdasarkan hasil uji coba perangkat lunak yang telah dikembangkan dari persepsi 30 siswa adalah 80,13 %. Perangkat lunak yang telah dikembangkan dapat dikategorikan sangat baik untuk digunakan sebagai alat bantu belajar dalam memahami istilah-istilah teknologi dan komputer khususnya dibidang pemrograman

Effects of buprenorphine on model development in an adjuvant-induced monoarthritis rat model

Complete Freund’s adjuvant (CFA)-induced arthritis in rats is a common animal model for studying chronic inflammatory pain. However, modelling of the disease is associated with unnecessary pain and impaired animal wellbeing, particularly in the immediate post-induction phase. Few attempts have been made to counteract these adverse effects with analgesics. The present study investigated the effect of buprenorphine on animal welfare, pain-related behaviour and model-specific parameters during the disease progression in a rat model of CFA-induced monoarthritis. The aim was to reduce or eliminate unnecessary pain in this model, in order to improve animal welfare and to avoid suffering, without compromising the quality of the model. Twenty-four male Sprague Dawley rats were injected with 20 μl of CFA into the left tibio-tarsal joint to induce monoarthritis. Rats were treated with either buprenorphine or carprofen for 15 days during the disease development, and were compared to a saline-treated CFA-injected group or a negative control group. Measurements of welfare, pain-related behaviour and clinical model-specific parameters were collected. The study was terminated after 3 weeks, ending with a histopathologic analysis. Regardless of treatment, CFA-injected rats displayed mechanical hyperalgesia and developed severe histopathological changes associated with arthritis. However, no severe effects on general welfare were found at any time. Buprenorphine treatment reduced facial pain expression scores, improved mobility, stance and lameness scores and it did not supress the CFA-induced ankle swelling, contrary to carprofen. Although buprenorphine failed to demonstrate a robust analgesic effect on the mechanical hyperalgesia in this study, it did not interfere with the development of the intended pathology

Rögnvaldur Hannesson, Debt, Democracy and the Welfare State: Are Modern Democracies Living on Borrewed Time and Money

Abstract. This book deals with the accumulation of government debt in twenty-two of the richest countries of the world, which has been ongoing since about the mid-1970s. All these countries are welfare states with a large government sector that provides services and transfers purchasing power to the perceived needy, although some countries are more ambitious in this respect than others. The build-up of debt is due to maintaining welfare expenditures beyond what tax revenues allow. But indefinite debt accumulation is not an option. The question is whether the governing elites in democratic countries will shrink from doing what is necessary in fear of losing their electorate, in the end opening the way to unenlightened populists and potential usurpers.Keywords. Dept, Democracy, Welfare State.JEL. D60, F34, I30, H60, P00

Effects of buprenorphine on acute pain and inflammation in the adjuvant-induced monoarthritis rat model

Background and aim: Animal modelling of arthritis is often associated with pain and suffering. Severity may be reduced with the use of analgesia which is, however, often withheld due to concerns of introducing a confounding variable. It is therefore important to design and validate pain relief protocols that reduce pain without compromising the scientific objectives. The present study evaluated the effect of buprenorphine analgesia in the immediate post-induction period of an adjuvant-induced monoarthritic rat model. The aim of this study was to extend previous work on refinement of the model by alleviating unnecessary pain. Methods: Male and female Sprague Dawley rats were injected with 20 μl of complete Freund's adjuvant (CFA) into the left ankle. Rats were treated with buprenorphine, either injected subcutaneously or ingested voluntarily, and were compared to rats given subcutaneous injections with vehicle (saline or pure nut paste) or carprofen the first three days post CFA-injection. Measurements of welfare, clinical model-specific parameters and pain-related behaviour were assessed. Results: Buprenorphine, administered either subcutaneously (0.10 or 0.15 mg/kg, twice daily) or by voluntary ingestion in nut paste (1.0 or 3.0 mg/kg, twice daily), improved mobility, stance, rearing and lameness scores significantly 7 h post CFA-injection. Mechanical hyperalgesia peaked at 7 h and was significantly lower in buprenorphine-treated animals, compared to vehicle-treated animals. Joint circumference was highest 24–72 h after CFA injection. Animals treated with buprenorphine did not decrease in joint circumference, opposite carprofen treated animals. Conclusion: Buprenorphine, administered either subcutaneously or by voluntary ingestion, provides adequate analgesia for both sexes within the first 24 h post CFA-injection. Buprenorphine treatment improved clinical scores and appeared not to suppress the inflammatory response. The present study supports previous findings that voluntarily ingested buprenorphine is an effective alternative to repeated injections

The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery

BACKGROUND: Translating efficacy of analgesic drugs from animal models to humans remains challenging. Reasons are multifaceted, but lack of sufficiently rigorous preclinical study design criteria and phenotypically relevant models may be partly responsible. To begin to address this fundamental issue, we assessed the analgesic efficacy of morphine in three inbred rat strains (selected based on stress reactivity and affective/pain phenotypes), and outbred Sprague Dawley (SD) rats supplied from two vendors. METHODS: Sensitivity to morphine (0.3-6.0 mg/kg, s.c.) was evaluated in the hot plate test of acute thermal nociception, the Complete Freund's Adjuvant (CFA) model of inflammatory-induced mechanical hyperalgesia, and in a locomotor motility assay in male rats from the following strains; Lewis (LEW), Fischer (F344), Wistar Kyoto (WKY), and SD's from Envigo and Charles River. RESULTS: F344 and SD rats were similarly sensitive to morphine in hot plate and CFA-induced inflammatory hyperalgesia (Minimum Effective Dose (MED) = 3.0 mg/kg). WKY rats developed a less robust mechanical hypersensitivity after CFA injection, and were less sensitive to morphine in both pain tests (MED = 6.0 mg/kg). LEW rats were completely insensitive to morphine in the hot plate test, in contrast to the reversal of CFA-induced hyperalgesia (MED = 3.0 mg/kg). All strains exhibited a dose-dependent reduction in locomotor activity at 3.0-6.0 mg/kg. CONCLUSION: Sensory phenotyping in response to acute thermal and inflammatory-induced pain, and sensitivity to morphine in various inbred and outbred rat strains indicates that different pathophysiological mechanisms are engaged after injury. This could have profound implications for translating preclinical drug discovery efforts into pain patients. SIGNIFICANCE: The choice of rat strain used in preclinical pain research can profoundly affect the outcome of experiments in relation to (a) nociceptive threshold responses, and (b) efficacy to analgesic treatment, in assays of acute and tonic inflammatory nociceptive pain