House in Hiro, Kure City, Hiroshima. Japan

[EN] This spacious house is a home that has two gardens. The site is located in a shopping district alongside the main highway, a harsh place to satisfy the demands of a client desiring a home with bright gardens. There are no outdoor gardens here, so we decided to plan out the kind of place that you could almost call a real garden, by bringing to the indoors materials that evoke - elements of the outdoors - garden-like elements such as light and raw materials.[ES] La espaciosa vivienda es un hogar que dispone de dos jardines. Está situada en un distrito comercial junto a la avenida principal.Suppose Design Office, A. (2010). Vivienda en Hiro, Kure City, Hiroshima. Japón. EN BLANCO. Revista de Arquitectura. 2(5):106-111. doi:10.4995/eb.2011.7222SWORD1061112

Critical Understanding of Myasthenia Gravis on the Basis of Vyadhi Ghatak

Myasthenia gravis (MG) is an autoimmune neuromuscular junction (NMJ) disorder characterized by weakness and fatigability of skeletal muscles. Myasthenia gravis has prevalence as high 200 in 100,000. It affects individuals in all age groups, but peak incidences occur in women in their twenties and thirties and in men in their fifties and sixties. Overall, women are affected more frequently than men, in a ratio of 3:2. It has bimodal age distribution. In MG, the fundamental defect is a decrease in the number of available AChRs at the postsynaptic muscle membrane. It presents with fluctuating skeletal muscle weakness and fatigue most commonly affecting the ocular muscles, although any muscle may be affected. In modern science treatment of Myasthenia gravis include anti-cholinesterase medications, glucocorticoids and other immunosuppressive agents. Long term use of steroid and immune modulator drugs has many adverse effects on other system of body. Ayurvedic therapies can give much more promising results. Comparison between myasthenia gravis and diseases explained in Ayurveda is difficult and exact correlation is not possible. But based on critical understanding of Vyadhighataka, a probable diagnosis can be made and treated accordingly. In this article, attempt is made to understand the pathogenesis of myasthenia gravis by considering the concepts of Dosha (vitiated Dosha), Dushya (vitiated Dushya), Aama, Agnimandya, and Srotovaigunya. For any disease pathology to begin, all components must be present. Pathogenesis of any disease will not occur without these elements