49 research outputs found
Enforcing the Unenforceable: Politicisation and the European Commission in the economic governance of the European Union
The politics of (de-)politicization and venue choice: A scoping review and research agenda on EU financial regulation and economic governance
Scholarly interest in EU financial regulation and economic governance has increased sharply over the last decade, but the literature on their politics remains fragmented. We present a scoping literature review which systematically locates and aggregates academic articles on their politics in ISI-ranked journals between 1999 and 2016. We identify lacunas in this literature by mapping its strands onto the EU political system. We then present a system-level research agenda that focuses on the cycles of depoliticization and politicization that strongly characterize the politics in these areas. Future research must pay careful attention to the conditions, mechanisms and, especially the venues that (dis)allow the linkage of societal politicization to EU-level politics. This approach is deeply rooted in the specifics of the politics of these policy areas, but also draws on the strengths of research in these areas to increase its relevance for broader debates on the future of the EU itself
Bread and butter or bread and circuses?
Does domestic contestation of European Union legitimacy affect the behaviour of the European Commission as an economic and fiscal supervisor? We draw on theories of bureaucratic responsiveness and employ multilevel and topic modelling to examine the extent to which the politicisation of European integration affects the outputs of the European Semester: the Country-Specific Recommendations. We develop two competing sets of hypotheses and test these on an original large-N data set on Commission behaviour with observations covering the period 2011–2017. We detect a twofold effect on the Commission's recommendations: member states that experience greater politicisation receive recommendations that are larger in scope but whose substance is less oriented towards social investment. We argue that this effect is best explained as an outcome of the Commission's institutional risk management strategy of regulatory ‘entrenchment’. The supranational agent issues additional recommendations while simultaneously entrenching on a stronger mandate substantively, which allows it to maintain its regulatory reputation and signal regulatory resolve to observing audiences
Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells
Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variants compared with Alpha variant in vaccinated individuals
The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) break through infection- or vaccine-induced immunity is not well understood. We analyzed 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. We found evidence of an increased risk of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared with the Alpha (B.1.1.7) variant after vaccination. No clear differences were found between vaccines. However, the effect was larger in the first 14 to 59 days after complete vaccination compared with ≥60 days. In contrast to vaccine-induced immunity, there was no increased risk for reinfection with Beta, Gamma, or Delta variants relative to the Alpha variant in individuals with infection-induced immunity.</p
Affecting qualitative health psychology
The ‘affective turn’ is a contemporary movement within the humanities, social science
and psychology to investigate affect, emotion and feeling as hybrid phenomena jointly
constituted from both biological and social influences. Health and illness are themselves
jointly constituted in this way, and many of the topics, concerns and methods of health
psychology are strongly permeated by affective phenomena. Qualitative research in
health psychology might therefore benefit by engaging with this work. This paper
describes some features of the affective turn, and suggests theories, terminology and
methods that might be useful
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors