A REVIEW: ANTIMICROBIAL AGENTS BASED ON NITROGEN AND SULFUR CONTAINING HETEROCYCLES

At present, heterocyclic compounds and their derived forms have become strong reflection in medicinal research field because of their positive pharmacological and biological properties. Heterocycles are prosperous in nature and have expanded additional importance because their structural subunits are established in many natural products such as antibiotics, vitamins, and hormones. Thiazine moieties present in compounds have multiplicity of medicinal activities such as antihypertensive, antitumor, antimicrobial, antibacterial, anticoagulant, antifungal, anticancer, and antiviral. This review article mainly based on thiazines and their derivatives with potential antimicrobial activities that are at this time in advancement.Keywords: Nitrogen, Sulfur heterocycles (thiazines), Antibacterial, Antifungal, Antimicrobial agents

A REVIEW: THIAZINES DERIVATIVES TREATED AS POTENTIAL ANTIMICROBIAL AGENTS

In recent days, heterocycles and their derivatives have become strong reflection in medicinal research and pharmaceutical fields because of their practical pharmacological and biological activities. Organic compounds; mainly heterocyclic compounds are wealthy in natural world and contain extra value because their structural subunits are established in many natural products such as enzymes, vitamins, antibiotics, acids, and hormones. Thiazine nucleuses found in compounds have variety of pharmacological activities such as antitumor, antimicrobial, antibacterial, antifungal, antiviral, and anti-inflammatory. This review spotlight on the substituted thiazines with possible antimicrobial activities that are at the present in development.Keywords: Antibacterial, Substituted thiazines, Antimicrobial agents.Â

Chronic non-puerperal uterine inversion: a rare case report

Uterine inversion though a rare entity but whenever diagnosed it is mostly seen in post partam cases. Chronic uterine inversion in non-parturient female is even rarer. Here we report such a case of chronic uterine inversion in non-puerperal period. Treatment depends on the associated pathology and the stage of the inversion. In our case we performed abdominal hysterectomy

Forbidden beta decay properties of 135,137^{135,137}Te using shell-model

In this work, the large-scale shell-model calculations for $\beta$-decay properties have been done. The $\beta$-delayed $\gamma$-ray spectroscopy has been performed recently at ILL, Grenoble [M. Si \textit{et al.}, Phys. Rev. C {\bf 106}, 014302 (2022)] to study $\beta$-decay properties corresponding to $^{137}$Te (($7/2^-))$ $\rightarrow$ $^{137}$I ($J_f$) transitions. We have done a systematic shell-model study for nuclear structure properties and compared the obtained results with the experimental data. Finally, the $\beta$-decay properties such as the $\log ft$ values and average shape factors have been reported. This is the first theoretical calculation for the $\log ft$ values corresponding to these new experimental data. In addition, we have also reported calculated $\log ft$ results for $^{135}$Te (($7/2^-))$ $\rightarrow$ $^{135}$I ($J_f$) transitions.Comment: 16 pages, 1 figure, 4 tables, Accepted in Nuclear Physics A (2023

Assessment Of In-Vivo Anti-Fibrotic Potential Of Fruit Seed Extract Of Indian Jujube (Ziziphus Mauritiana) Using 2-Nitropropane Induced Hepatic Fibrosis Model.

Injury to the liver is a significant public health issue that affects people all over the world, which necessitates the creation of innovative treatments that are both effective and safe. Due to the antioxidant activity that it possesses, Ziziphus mauritiana (Z. mauritiana) has traditionally been considered to have therapeutic potential against many organ toxicity disorders. In the current work, the objective was to assess the antioxidant activities in vitro and the potential hepatoprotective effects of hydroethanolic extracts from Z. mauritiana seeds (ZMSE) against 2-nitropropane (2-NP) produced liver damage (Fibrosis) in rats. Additionally, the phytochemical contents of the extracts were to be identified. Through in vitro testing, the extract demonstrated significant antioxidant properties, as well as a high quantity of flavonoids and other phenolic compounds respectively. By activating the hepatic antioxidant defense mechanisms, modulating hepatic functions, and decreasing the production of lipid peroxidation, pro-inflammatory mediators, and collagen content, oral administration of ZMSE (especially high dose) significantly suppressed the incidence and severity of 2-NP-induced liver toxicity. However, the degree of suppression varied depending on the dose. There is a possibility that the presence of phenolic acids, flavonoids, and diterpenoids is responsible for these activities. These findings demonstrate the antioxidant and anti-inflammatory properties of ZMSE when administered in varying doses (200, 400, or 800 mg/kg body weight), demonstrate the protective and beneficial effects of the seed against 2-NP-induced hepatic toxicity in rats, and provide support for its consumption, traditional uses, and the promotion of its valorization as a nutraceutical product. &nbsp

MANAGEMENT OF AUTISM SPECTRUM DISORDER WITH ABHAYAGHRITA AND PANCHA BHAUTIKA TAILANASYA- A CASE REPORT

Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental condition with its onset before the age of three years. It is characterized by abnormalities in communication, impaired social function, repetitive behaviours and restricted interests. There is no effective treatment currently available for ASD and there is a growing need of an alternative treatment modality. A three year six month old male patient, diagnosed with ASD was brought to the OPD for Ayurvedic treatment of ASD. There is no mention of ASD in Ayurveda classics and hence, considered an Anukta Vyadhi. ASD involves vitiation of all the three Doshas mainly Vata Dosha in the lead. The management was primarily based on the associated Doshas and Ayurvedic formulations i.e. Abhaya Ghrita orally for three months and Marsha Nasya with Panchabhautika Taila for forty five days were used. Changes in the clinical features were assessed using Aberrant Behaviour Checklist (ABC) and changes in the severity of disease after treatment was done using Clinical Global Impression scale (CGI). The patient showed significant improvement in the core features of ASD after the treatment duration

OPTIMIZATION AND CHARACTERIZATION OF CHITOSAN-BASED NANOPARTICLES CONTAINING METHYLPREDNISOLONE USING BOX-BEHNKEN DESIGN FOR THE TREATMENT OF CROHN’S DISEASE

Objective: The present research was designed to produce methylprednisolone containing chitosan-based nanoparticles using Box-Behnken Design (BBD) and Response Surface Methodology (RSM) for optimization. Methods: Nanostructures were prepared using the ionic gelation method with screened process parameters. According to the design, methylprednisolone chitosan-based nanoparticles (MCSNPs) were optimized using factors like methylprednisolone concentration, stirring speed and temperature whereas particle size, zeta potential and % encapsulation efficiency as responses. From the observed values of responses with confirmation location and desirability, the predicted values were very close to the observed values. Results: Observed values for the optimized formulation have a particle size of 243±2.33 nm with an encapsulation efficiency of 79.3±7.2%. Morphology of the particles using scanning electron microscopy reveals nearly spherical shaped particles. Methylprednisolone was released in vitro in a sustained manner for about 24 h in simulated colonic fluid pH 7, pH 7.8 (Fasted state) and phosphate buffer pH 7.4, when compared to simulated colonic fluid at pH 6 (Fed state). Optimized MCSNPs followed Korsmeyer peppas kinetics with drug release mechanism as anomalous transport. Conclusion: Application of Box-Behnken design and Response Surface Methodology using Design Expert software was successfully used in the optimization of methylprednisolone loaded chitosan-based nanoparticles with high encapsulation efficiency