1,482 research outputs found
Alien Registration- Lachance, Joseph A. (Fort Fairfield, Aroostook County)
https://digitalmaine.com/alien_docs/35969/thumbnail.jp
Alien Registration- Lachance, Rose A. (Sanford, York County)
https://digitalmaine.com/alien_docs/3233/thumbnail.jp
Managing at the Speed of Light: Improving Mission-Support Performance
The House and Senate Energy and Water Development Appropriations Subcommittees requested this study to help DOE's three major mission-support organizations improve their operations to better meet the current and future needs of the department. The passage of the Recovery Act only increased the importance of having DOE's mission-support offices working in the most effective, efficient, and timely manner as possible. While following rules and regulations is essential, the foremost task of the mission-support offices is to support the department's mission, i.e., the programs that DOE is implementing, whether in Washington D.C. or in the field. As a result, the Panel offered specific recommendations to strengthen the mission-focus and improve the management of each of the following support functions based on five "management mandates":- Strategic Vision- Leadership- Mission and Customer Service Orientation- Tactical Implementation- Agility/AdaptabilityKey FindingsThe Panel made several recommendations in each of the functional areas examined and some overarching recommendations for the corporate management of the mission-support offices that they believed would result in significant improvements to DOE's mission-support operations. The Panel believed that adopting these recommendations will not only make DOE a better functioning organization, but that most of them are essential if DOE is to put its very large allocation of Recovery Act funding to its intended uses as quickly as possible
Absence of correlation between nitrate reductase and symbiotic nitrogen fixation efficiency in rhizobium meliloti
Les activités spécifiques des nitrates réductases assimilatoires et "régulatoires" ont été étudiées chez 41 souches de Rhizobium meliloti ayant des activités différentes de fixation symbiotique d’azote. Les deux nitrates réductases ont été retrouvées chez les souches très efficaces ainsi que chez les souches inefficaces et aucune corrélation significative n’a été trouvée entre les activités spécifiques et le rendement de la matière sèche de la luzerne obtenu avec les 41 souches à l’essai. La détermination des activités spécifiques de ces deux nitrates réductases chez les bactéries végétatives ne peut donc pas être utilisée comme un test physiologique rapide pour la sélection de souches très efficaces de R. meliloti.Specific activities of the assimilatory and "regulatory" types of nitrate reductase
were studied in 41 strains of Rhizobium m,eliloti naving ditierent symbiotic nitrogen
fixation activities. Both nitrate reductase enzymes were present in very effective ind
ineffective strains and no significant correlation was iound between the specific
activities of the two enzymes and the dry matter yields of alfalfa obtained with the 41
strains. Measurements of the specific activities of the two nitrate reductase enzymes in
the vegetative bacteria cannot be used as a rapid physiological test for the seiection of
very effective strains of R. meliloti
Sleep Characteristics and Behavioral Problems Among Children of Alcoholics and Controls
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142546/1/acer13585_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142546/2/acer13585.pd
Transcriptional analysis of PRRSV-infected porcine dendritic cell response to Streptococcus suis infection reveals up-regulation of inflammatory-related genes expression
The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important
swine pathogens and often serves as an entry door for other viral or bacterial pathogens,
of which Streptococcus suis is one of the most common. Pre-infection with PRRSV
leads to exacerbated disease caused by S. suis infection. Very few studies have assessed
the immunological mechanisms underlying this higher susceptibility. Since antigen presenting
cells play a major role in the initiation of the immune response, the in vitro transcriptional
response of bone marrow-derived dendritic cells (BMDCs) and monocytes in the context of
PRRSV and S. suis co-infection was investigated. BMDCs were found to be more permissive
than monocytes to PRRSV infection; S. suis phagocytosis by PRRSV-infected BMDCs
was found to be impaired, whereas no effect was found on bacterial intracellular survival.
Transcription profile analysis, with a major focus on inflammatory genes, following S. suis
infection, with and without pre-infection with PRRSV, was then performed. While PRRSV
pre-infection had little effect on monocytes response to S. suis infection, a significant
expression of several pro-inflammatory molecules was observed in BMDCs pre-infected
with PRRSV after a subsequent infection with S. suis. While an additive effect could be
observed for CCL4, CCL14, CCL20, and IL-15, a distinct synergistic up-regulatory effect
was observed for IL-6, CCL5 and TNF-α after co-infection. This increased pro-inflammatory
response by DCs could participate in the exacerbation of the disease observed during
PRRSV and S. suis co-infection
Evolving antibiotics against resistance : a potential platform for natural product development?
To avoid an antibiotic resistance crisis, we need to develop antibiotics at a pace that matches the rate of evolution of resistance. However, the complex functions performed by antibiotics—combining, e.g., penetration of membranes, counteraction of resistance mechanisms, and interaction with molecular targets— have proven hard to achieve with current methods for drug development, including target-based screening and rational design. Here, we argue that we can meet the evolution of resistance in the clinic with evolution of antibiotics in the laboratory. On the basis of the results of experimental evolution studies of microbes in general and antibiotic production in Actinobacteria in particular, we propose methodology for evolving antibiotics to circumvent mechanisms of resistance. This exploits the ability of evolution to find solutions to complex problems without a need for design. We review evolutionary theory critical to this approach and argue that it is feasible and has important advantages over current methods for antibiotic discovery
Weight perceptions and perceived risk for diabetes and heart disease among overweight and obese women, Suffolk County, New York, 2008
INTRODUCTION: Many Americans fail to accurately identify themselves as overweight and underestimate their risk for obesity-related diseases. The purpose of this study was to investigate associations between weight perceptions and perceived risk for diabetes and heart disease among overweight or obese women. METHODS: We examined survey responses from 397 overweight or obese female health center patients on disease risk perceptions and weight perceptions. We derived odds ratios (ORs) and 95% confidence intervals (CIs) from multivariable logistic regression analyses to examine predictors of perceived risk for diabetes and heart disease. We further stratified results by health literacy. RESULTS: Perceiving oneself as overweight (OR, 2.78; 95% CI, 1.16-6.66), believing that being overweight is a personal health problem (OR, 2.46; 95% CI, 1.26-4.80), and family history of diabetes (OR, 3.22; 95% CI, 1.53-6.78) were associated with greater perceived risk for diabetes. Perceiving oneself as overweight (OR, 4.33; 95% CI, 1.26-14.86) and family history of heart disease (OR, 2.25; 95% CI, 1.08-4.69) were associated with greater perceived risk for heart disease. Among respondents with higher health literacy, believing that being overweight was a personal health problem was associated with greater perceived risk for diabetes (OR, 4.91; 95% CI, 1.68-14.35). Among respondents with lower health literacy, perceiving oneself as overweight was associated with greater perceived risk for heart disease (OR, 4.69; 95% CI, 1.02-21.62). CONCLUSION: Our findings indicate an association between accurate weight perceptions and perceived risk for diabetes and heart disease in overweight or obese women. This study adds to research on disease risk perceptions in at-risk populations
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