Viewpoint on handling anti-TNF failure in psoriasis

An association among the occurrence of antidrug antibodies (ADAs), diminished trough serum drug levels (TSDLs) and non-response or loss of response has been described for several tumor necrosis factor alpha (TNF) blocking agents in a variety of diseases, including psoriasis. In a series of ten psoriasis patients with primary or secondary failure, or adverse reactions during anti-TNF therapy, we measured ADAs and TSDLs in patient serum using radioimmunoassay and ELISA, respectively. By proposing a treatment algorithm derived from research in this field, we show that measuring ADAs and TSDLs in psoriasis patients provides a more structured approach to clinical decision making for psoriasis patients who fail anti-TNF therapy

Adaptive driver modelling in ADAS to improve user acceptance: A study using naturalistic data

Accurate understanding of driver behaviour is crucial for future Advanced Driver Assistance Systems (ADAS) and autonomous driving. For user acceptance it is important that ADAS respect individual driving styles and adapt accordingly. Using data collected during a naturalistic driving study carried out at the University of Southampton, we assess existing models of driver acceleration and speed choice during car following and when cornering. We observe that existing models of driver behaviour that specify a preferred inter-vehicle spacing in car-following situations appear to be too prescriptive, with a wide range of acceptable spacings visible in the naturalistic data. Bounds on lateral acceleration during cornering from the literature are visible in the data, but appear to be influenced by the minimum cornering radii specified in design codes for UK roadway geometry. This analysis of existing driver models is used to suggest a small set of parameters that are sufficient to characterise driver behaviour in car-following and curve driving, which may be estimated in real-time by an ADAS to adapt to changing driver behaviour. Finally, we discuss applications to adaptive ADAS with the objectives of improving road safety and promoting eco-driving, and suggest directions for future researc

THE USE of VEHICLE DATA in ADAS DEVELOPMENT, VERIFICATION and FOLLOW-UP on the SYSTEM

Advanced Driver Assistance Systems (ADAS) require a high level of interaction between the driver and the system, depending on driving context at a particular moment. Context-aware ADAS evaluation based on vehicle data is the most prominent way to assess the complexity of ADAS interactions. In this study, we conducted interviews with the ADAS development team at Volvo Cars to understand the role of vehicle data in the ADAS development and evaluation. The interviews\u27 analysis reveals strategies for improvement of current practices for vehicle data-driven ADAS evaluation

Organic Arable Systems at ADAS Terrington OF0112

Project OF0112 contributes to MAFF's main policy focus of encouraging conversion to organic farming methods. It is part of a long term rotational study that began in 1990 as OF0102 and has recently been extended to 2001 as OF0145. The overall objective of these three projects is to evaluate the cost of conversion to organic arable production on a fertile soil, to assess the physical and financial performance of the organic rotation, to identify and overcome limitations to sustainabilty and to compare the results with conventional arable production. The project comprises a field-scale unreplicated systems comparison and associated replicated experiments at ADAS Terrington, and a financial analysis of ten commercial 'linked' organic farms. The silty clay loam soil at Terrington has proved ideal for organic production, primarily because it has very good water and nutrient and retention. As expected, organic crop yields have been less than conventional, averaging 70% for winter wheat; yields have been, on average, double that of the linked farms, and reached a peak of 10 t/ha in 1996. Variable costs have been lower and organic prices have been twice or more that for conventionally grown potatoes and wheat. Crop grossmargins (i.e. the value of the crop harvested minus the drect variable costs of growing it) have been consistently higher from organic than conventional. Even allowing for the lower value of the other three crops in the rotation, i.e. beans, spring cereal and clover (Set aside), overall gross margin from organic was higher than from conventional (average from 1993 to 1997 was 1,878 v 1,290 #/ha). Crop yields and gross margins were generally lower on the linked farms, probably mainly because they were on lighter soils more prone to leaching losses. However, all were viable businesses and had similar profitabilities to conventional farms of their size. The most profitable rotations in cluded potatoes and/or vegetables. In the absence of animal manures and synthetic fertilisers, the main driver of crop yield and key to sucess, will be the fixation of sufficient atmospheric nitrogen by the Rhizobium bacteria in the root nodules of legumes. Replicated experiments comparing a range of species have shown that in terms of gross accumulation of nitrogen in the cut foliage, and in the yield of a following wheat crop, red clover, lucerne and white clover are all very effective fertility builders, with red clover on average just the best. A second experiment has compared wheat, barley and oats as the cover crops for the undersowing of red clover. In 1997 clover dry matter at harvest uder oats was only 4.5kg/ha compared with 88 under wheat and 74 under barley. Baley was also the most profitable crop, however this was affected by relative grain prices which vary between years. A third experiment tested timing of manure application across the rotation. The modest quantity applied (30 t/ha per rotation) was chosen as what could have been produced from animals fed on crops grown within the rotation. There was only one isolated response in crop yield over four different crops. This was probably a reflection of the high inherent fertility and nitrogen retention capacity of the silty clay loam soil at Terrington. There are real current business opportunities for conversion to arable production. The linked farms, mostly with mixed arable livestock rotations, show profitability comparable with conventional; stockless arable production was consistently more profitable than conventional on the fertile nutrient retentive soil at Terrington. However there remain questions about the longer term sustainability of a stockless arable rotation, even on such a well suited soil. The next phase of the project (OF0145), which has just started, will focus on sustainability studying potential threats from perennial weeds, nutrient supply and soil-borne pests and diseases. The use of manure will be discontinued and, in that part of the study area, vegetables will be introduced in place of potatoes to test an alternative rotation

Effects of the driving context on the usage of Automated Driver Assistance Systems (ADAS) -Naturalistic Driving Study for ADAS evaluation

Automated Driver Assistance Systems (ADAS) are designed to support the driver and enhance the driving experience. Due to ADAS limitations associated with the driving context, the intended use of ADAS functions is often non-transparent for the end-user. The system performance capabilities affected by the continuously changing driving context influence ADAS usage. However, the cumulative effect of the driving context on driver behavior and ADAS usage is insufficiently covered in the ongoing research. This paper aims to investigate and understand how the driving context affects the use of ADAS. Throughout this research, data from a Naturalistic Driving (ND) study was collected and analyzed. The analysis of the ND data helped to register how drivers use ADAS in different driving conditions and indicated several issues associated with ADAS usage. To be able to clarify the outcomes of quantitative sensor-based data analysis, an explanatory sequential mixed-method design was implemented. The method facilitated the subsequent design of qualitative in-depth interviews with the drivers. The combined data analysis allowed a holistic interpretation and evaluation of the findings regarding the effect of the driving context on ADAS usage. The findings warrant consideration of the driving context as a key factor enabling the effective development of ADAS functions.\ua0\ua9 2020 The Author

Detection of anti-infliximab antibodies is impacted by antibody titer, infliximab level and IgG4 antibodies: a systematic comparison of three different assays

Background: There is scant information on the accuracy of different assays used to measure anti-infliximab antibodies (ADAs), especially in the presence of detectable infliximab (IFX). We thus aimed to evaluate and compare three different assays for the detection of IFX and ADAs and to clarify the impact of the presence of circulating IFX on the accuracy of the ADA assays.Methods: Blood samples from 79 ulcerative colitis (UC) patients treated with infliximab were assessed for IFX levels and ADAs using three different assays: an in-house assay and two commercial kits, Immundiagnostik and Theradiag. Sera samples with ADAs and undetectable levels of IFX were spiked with exogenous IFX and analyzed for ADAs.Results: The three assays showed 81-96% agreement for the measured IFX level. However, the in-house assay and Immundiagnostik assays detected ADAs in 34 out of 79 samples, whereas Theradiag only detected ADAs in 24 samples. Samples negative for ADAs with Theradiag, but ADA-positive in both the in-house and Immundiagnostik assays, were positive for IFX or IgG4 ADAs. In spiking experiments, a low concentration of exogenous IFX (5 mu g/ml) hampered ADA detection with Theradiag in sera samples with ADA levels of between 3 and 10 mu g/ml. In the Immundiagnostik assay detection interference was only observed at concentrations of exogenous IFX higher than 30 mu g/ml. However, in samples with high levels of ADAs (> 25 mu g/ml) interference was only observed at IFX concentrations higher than 100 mu g/ml in all three assays. Binary (IFX/ADA) stratification of the results showed that IFX+/ADA and IFX-/ADAs + were less influenced by the assay results than the double-positive (IFX+/ADAs+) and double-negative (IFX-/ADAs-) combination.Conclusions: All three methodologies are equally suitable for measuring IFX levels. However, erroneous therapeutic decisions may occur when patients show double-negative (IFX-/ADAs) or double-positive (IFX+/ADAs+) status, since agreement between assays is significantly lower in these circumstances

Design of a data-driven communication framework as personalized support for users of ADAS

Recently the automotive industry has made a huge leap forward in Automated Driver Assistance Systems (ADAS) development, increasing the level of driving processes automation. However, ADAS design does not imply any individual support to the driver; this results in a poor understanding of how the ADAS works and its limitations. This type of driver uncertainty regarding ADAS performance can erode the user\u27s trust in the system and result in decreasing situations when the system is in use. This paper presents the design of a data-driven communication framework that can utilize historical and real-time vehicle data to support ADAS users. The data-driven communication framework aims to illustrate the ADAS capabilities and limitations and suggests effective use of the system in real-time driving situations. This type of assistance can improve a driver\u27s understanding of ADAS functionality and encourage its usage