Automated analysis of quantitative image data using isomorphic functional mixed models, with application to proteomics data

Image data are increasingly encountered and are of growing importance in many areas of science. Much of these data are quantitative image data, which are characterized by intensities that represent some measurement of interest in the scanned images. The data typically consist of multiple images on the same domain and the goal of the research is to combine the quantitative information across images to make inference about populations or interventions. In this paper we present a unified analysis framework for the analysis of quantitative image data using a Bayesian functional mixed model approach. This framework is flexible enough to handle complex, irregular images with many local features, and can model the simultaneous effects of multiple factors on the image intensities and account for the correlation between images induced by the design. We introduce a general isomorphic modeling approach to fitting the functional mixed model, of which the wavelet-based functional mixed model is one special case. With suitable modeling choices, this approach leads to efficient calculations and can result in flexible modeling and adaptive smoothing of the salient features in the data. The proposed method has the following advantages: it can be run automatically, it produces inferential plots indicating which regions of the image are associated with each factor, it simultaneously considers the practical and statistical significance of findings, and it controls the false discovery rate.Comment: Published in at http://dx.doi.org/10.1214/10-AOAS407 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Multi-Sensor Image Fusion Based on Moment Calculation

An image fusion method based on salient features is proposed in this paper. In this work, we have concentrated on salient features of the image for fusion in order to preserve all relevant information contained in the input images and tried to enhance the contrast in fused image and also suppressed noise to a maximum extent. In our system, first we have applied a mask on two input images in order to conserve the high frequency information along with some low frequency information and stifle noise to a maximum extent. Thereafter, for identification of salience features from sources images, a local moment is computed in the neighborhood of a coefficient. Finally, a decision map is generated based on local moment in order to get the fused image. To verify our proposed algorithm, we have tested it on 120 sensor image pairs collected from Manchester University UK database. The experimental results show that the proposed method can provide superior fused image in terms of several quantitative fusion evaluation index.Comment: 5 pages, International Conferenc

Automated detection of extended sources in radio maps: progress from the SCORPIO survey

Automated source extraction and parameterization represents a crucial challenge for the next-generation radio interferometer surveys, such as those performed with the Square Kilometre Array (SKA) and its precursors. In this paper we present a new algorithm, dubbed CAESAR (Compact And Extended Source Automated Recognition), to detect and parametrize extended sources in radio interferometric maps. It is based on a pre-filtering stage, allowing image denoising, compact source suppression and enhancement of diffuse emission, followed by an adaptive superpixel clustering stage for final source segmentation. A parameterization stage provides source flux information and a wide range of morphology estimators for post-processing analysis. We developed CAESAR in a modular software library, including also different methods for local background estimation and image filtering, along with alternative algorithms for both compact and diffuse source extraction. The method was applied to real radio continuum data collected at the Australian Telescope Compact Array (ATCA) within the SCORPIO project, a pathfinder of the ASKAP-EMU survey. The source reconstruction capabilities were studied over different test fields in the presence of compact sources, imaging artefacts and diffuse emission from the Galactic plane and compared with existing algorithms. When compared to a human-driven analysis, the designed algorithm was found capable of detecting known target sources and regions of diffuse emission, outperforming alternative approaches over the considered fields.Comment: 15 pages, 9 figure