Uncertainty in phylogenetic tree estimates

Estimating phylogenetic trees is an important problem in evolutionary biology, environmental policy and medicine. Although trees are estimated, their uncertainties are discarded by mathematicians working in tree space. Here we explicitly model the multivariate uncertainty of tree estimates. We consider both the cases where uncertainty information arises extrinsically (through covariate information) and intrinsically (through the tree estimates themselves). The importance of accounting for tree uncertainty in tree space is demonstrated in two case studies. In the first instance, differences between gene trees are small relative to their uncertainties, while in the second, the differences are relatively large. Our main goal is visualization of tree uncertainty, and we demonstrate advantages of our method with respect to reproducibility, speed and preservation of topological differences compared to visualization based on multidimensional scaling. The proposal highlights that phylogenetic trees are estimated in an extremely high-dimensional space, resulting in uncertainty information that cannot be discarded. Most importantly, it is a method that allows biologists to diagnose whether differences between gene trees are biologically meaningful, or due to uncertainty in estimation.Comment: Final version accepted to Journal of Computational and Graphical Statistic

Fast filtering and animation of large dynamic networks

Detecting and visualizing what are the most relevant changes in an evolving network is an open challenge in several domains. We present a fast algorithm that filters subsets of the strongest nodes and edges representing an evolving weighted graph and visualize it by either creating a movie, or by streaming it to an interactive network visualization tool. The algorithm is an approximation of exponential sliding time-window that scales linearly with the number of interactions. We compare the algorithm against rectangular and exponential sliding time-window methods. Our network filtering algorithm: i) captures persistent trends in the structure of dynamic weighted networks, ii) smoothens transitions between the snapshots of dynamic network, and iii) uses limited memory and processor time. The algorithm is publicly available as open-source software.Comment: 6 figures, 2 table

Studying the Emerging Global Brain: Analyzing and Visualizing the Impact of Co-Authorship Teams

This paper introduces a suite of approaches and measures to study the impact of co-authorship teams based on the number of publications and their citations on a local and global scale. In particular, we present a novel weighted graph representation that encodes coupled author-paper networks as a weighted co-authorship graph. This weighted graph representation is applied to a dataset that captures the emergence of a new field of science and comprises 614 papers published by 1,036 unique authors between 1974 and 2004. In order to characterize the properties and evolution of this field we first use four different measures of centrality to identify the impact of authors. A global statistical analysis is performed to characterize the distribution of paper production and paper citations and its correlation with the co-authorship team size. The size of co-authorship clusters over time is examined. Finally, a novel local, author-centered measure based on entropy is applied to determine the global evolution of the field and the identification of the contribution of a single author's impact across all of its co-authorship relations. A visualization of the growth of the weighted co-author network and the results obtained from the statistical analysis indicate a drift towards a more cooperative, global collaboration process as the main drive in the production of scientific knowledge.Comment: 13 pages, 9 figure