Fog-supported delay-constrained energy-saving live migration of VMs over multiPath TCP/IP 5G connections

The incoming era of the fifth-generation fog computing-supported radio access networks (shortly, 5G FOGRANs) aims at exploiting computing/networking resource virtualization, in order to augment the limited resources of wireless devices through the seamless live migration of virtual machines (VMs) toward nearby fog data centers. For this purpose, the bandwidths of the multiple wireless network interface cards of the wireless devices may be aggregated under the control of the emerging MultiPathTCP (MPTCP) protocol. However, due to the fading and mobility-induced phenomena, the energy consumptions of the current state-of-the-art VM migration techniques may still offset their expected benefits. Motivated by these considerations, in this paper, we analytically characterize and implement in software and numerically test the optimal minimum-energy settable-complexity bandwidth manager (SCBM) for the live migration of VMs over 5G FOGRAN MPTCP connections. The key features of the proposed SCBM are that: 1) its implementation complexity is settable on-line on the basis of the target energy consumption versus implementation complexity tradeoff; 2) it minimizes the network energy consumed by the wireless device for sustaining the migration process under hard constraints on the tolerated migration times and downtimes; and 3) by leveraging a suitably designed adaptive mechanism, it is capable to quickly react to (possibly, unpredicted) fading and/or mobility-induced abrupt changes of the wireless environment without requiring forecasting. The actual effectiveness of the proposed SCBM is supported by extensive energy versus delay performance comparisons that cover: 1) a number of heterogeneous 3G/4G/WiFi FOGRAN scenarios; 2) synthetic and real-world workloads; and, 3) MPTCP and wireless connections

Trusted Computing and Secure Virtualization in Cloud Computing

Large-scale deployment and use of cloud computing in industry is accompanied and in the same time hampered by concerns regarding protection of data handled by cloud computing providers. One of the consequences of moving data processing and storage off company premises is that organizations have less control over their infrastructure. As a result, cloud service (CS) clients must trust that the CS provider is able to protect their data and infrastructure from both external and internal attacks. Currently however, such trust can only rely on organizational processes declared by the CS provider and can not be remotely verified and validated by an external party. Enabling the CS client to verify the integrity of the host where the virtual machine instance will run, as well as to ensure that the virtual machine image has not been tampered with, are some steps towards building trust in the CS provider. Having the tools to perform such verifications prior to the launch of the VM instance allows the CS clients to decide in runtime whether certain data should be stored- or calculations should be made on the VM instance offered by the CS provider. This thesis combines three components -- trusted computing, virtualization technology and cloud computing platforms -- to address issues of trust and security in public cloud computing environments. Of the three components, virtualization technology has had the longest evolution and is a cornerstone for the realization of cloud computing. Trusted computing is a recent industry initiative that aims to implement the root of trust in a hardware component, the trusted platform module. The initiative has been formalized in a set of specifications and is currently at version 1.2. Cloud computing platforms pool virtualized computing, storage and network resources in order to serve a large number of customers customers that use a multi-tenant multiplexing model to offer on-demand self-service over broad network. Open source cloud computing platforms are, similar to trusted computing, a fairly recent technology in active development. The issue of trust in public cloud environments is addressed by examining the state of the art within cloud computing security and subsequently addressing the issues of establishing trust in the launch of a generic virtual machine in a public cloud environment. As a result, the thesis proposes a trusted launch protocol that allows CS clients to verify and ensure the integrity of the VM instance at launch time, as well as the integrity of the host where the VM instance is launched. The protocol relies on the use of Trusted Platform Module (TPM) for key generation and data protection. The TPM also plays an essential part in the integrity attestation of the VM instance host. Along with a theoretical, platform-agnostic protocol, the thesis also describes a detailed implementation design of the protocol using the OpenStack cloud computing platform. In order the verify the implementability of the proposed protocol, a prototype implementation has built using a distributed deployment of OpenStack. While the protocol covers only the trusted launch procedure using generic virtual machine images, it presents a step aimed to contribute towards the creation of a secure and trusted public cloud computing environment

GNFC: Towards Network Function Cloudification

An increasing demand is seen from enterprises to host and dynamically manage middlebox services in public clouds in order to leverage the same benefits that network functions provide in traditional, in-house deployments. However, today's public clouds provide only a limited view and programmability for tenants that challenges flexible deployment of transparent, software-defined network functions. Moreover, current virtual network functions can't take full advantage of a virtualized cloud environment, limiting scalability and fault tolerance. In this paper we review and evaluate the current infrastructural limitations imposed by public cloud providers and present the design and implementation of GNFC, a cloud-based Network Function Virtualization (NFV) framework that gives tenants the ability to transparently attach stateless, container-based network functions to their services hosted in public clouds. We evaluate the proposed system over three public cloud providers (Amazon EC2, Microsoft Azure and Google Compute Engine) and show the effects on end-to-end latency and throughput using various instance types for NFV hosts

Biomarkers in sepsis.

Purpose of review: This review discusses the current developments in biomarkers for sepsis. Recent findings: With quantum leaps in technology, an array of biomarkers will become available within the next decade as point-of-care tools that will likely revolutionize the management of sepsis. These markers will facilitate early and accurate diagnosis, faster recognition of impending organ dysfunction, optimal selection and titration of appropriate therapies, and more reliable prognostication of risk and outcome. These diagnostics will also enable an improved characterization of the biological phenotype underlying sepsis and thus a better appreciation of the condition. Summary: The potential for novel biomarkers in sepsis will need to be properly realized with considerable funding, academic–industry collaborations, appropriate investigations and validation in heterogenous populations, but these developments do hold the capacity to transform patient care and outcomes