Association Between Vestibular Migraine and Migraine Headache: Yet to Explore.

ObjectivesTo evaluate if patients with a diagnosis of vestibular migraine (VM) by the International Classification of Headache Disorders (ICHD) criteria have meaningful differences in symptomatology and disease characteristics when compared to patients with concurrent vestibular symptoms and migraine that do not meet ICHD criteria.MethodsPatients who presented for the evaluation of vertigo were provided a detailed questionnaire about dizziness and migraine symptoms. Patients were assigned to either VM cohort (met ICHD criteria for VM) or migraine headache (MH) cohort (met ICHD criteria for migraine with or without aura but not VM). Disease characteristics, symptomatology, quality of life, and perceived stress score were compared between the cohorts.ResultsThe VM cohort demonstrated a shorter duration of vertigo episodes, 11 ± 22 hours versus 84 ± 146 hours in the MH cohort. In the VM cohort, 81% reported experiencing migraine headaches during episodes of vertigo, versus 61% in the MH cohort. All patients in the VM cohort reported a previous diagnosis of migraine headache, whereas 9% of the MH cohort had not been previously diagnosed by another physician. There was no difference in quality of life or perceived stress scores between the cohorts.ConclusionsA large proportion of vertigo patients with migrainous features do not meet the ICHD criteria for VM. The differences between cohorts represent selection bias rather than meaningful features unique to the cohorts. As such, VM and MH with vestibular symptoms may exist on a spectrum of the same disease process and may warrant the same treatment protocols

Diffusion bonding of IN 718 to VM 350 grade maraging steel

Diffusion bonding studies have been conducted on IN 718, VM 350 and the dissimilar alloy couple, IN 718 to maraging steel. The experimental processing parameters critical to obtaining consistently good diffusion bonds between IN 718 and VM 350 were determined. Interrelationships between temperature, pressure and surface preparation were explored for short bending intervals under vacuum conditions. Successful joining was achieved for a range of bonding cycle temperatures, pressures and surface preparations. The strength of the weaker parent material was used as a criterion for a successful tensile test of the heat treated bond. Studies of VM-350/VM-350 couples in the as-bonded condition showed a greater yielding and failure outside the bond region

Dominance attributions following damage to the ventromedial prefrontal cortex

Damage to the human ventromedial prefrontal cortex (VM) can result in dramatic and maladaptive changes in social behavior despite preservation of most other cognitive abilities. One important aspect of social cognition is the ability to detect social dominance, a process of attributing from particular social signals another person's relative standing in the social world. To test the role of the VM in making attributions of social dominance, we designed two experiments: one requiring dominance judgments from static pictures of faces, the second requiring dominance judgments from film clips. We tested three demographically matched groups of subjects: subjects with focal lesions in the VM (n=15), brain-damaged comparison subjects with lesions excluding the VM (n=11), and a reference group of normal individuals with no history of neurological disease (n=32). Contrary to our expectation, we found that subjects with VM lesions gave dominance judgments on both tasks that did not differ significantly from those given by the other groups. Despite their grossly normal performance, however, subjects with VM lesions showed more subtle impairments specifically when judging static faces: They were less discriminative in their dominance judgments, and did not appear to make normal use of gender and age of the faces in forming their judgments. The findings suggest that, in the laboratory tasks we used, damage to the VM does not necessarily impair judgments of social dominance, although it appears to result in alterations in strategy that might translate into behavioral impairments in real life

Effects of Lift Velocity on Muscle Activation During Leg Extension

It is not known if manipulating velocity within a prescribed resistance training mode will improve muscle activation. Muscle activations of the Rectus Femoris (RF), Vastus Lateralis (VL), Vastus Medialis (VM) and Bicep Femoris (BF) were examined during a leg extension exercise at 3 different velocities on 15 subjects (10men, 5 female, Age = 21.5 ± 1.8 yrs, Height = 171.2 ± 12.5 cm, Mass = 75.5 ± 16.3 kg). Trials of 1 set of 10 repetitions at 60% of 1RM, were performed at 15, 30 and 60º/s. Bipolar surface electrodes were placed over the BF, RF, VL, and VM. Micro-switches were utilized to identify the concentric (CON) and eccentric (ECC) phases of the lift. Data were sampled at 1024 Hz, filtered, rectified and the mean, integrated EMG calculated. One 2 x 4 x 3 (action x muscle x velocity) ANOVA with bonferonni adjustment was run and significance was followed by Tukey HSD post hoc analysis. Results indicated significantly greater activation of the VL, RF and VM for ECC extension at 60º/s compared to 15º/s. While 60º/s was also greater than 30º/s for the VL and VM during ECC. While comparing muscle action, CON VL, VM and RF were greater than ECC at 30º/sec, meanwhile VM CON was also greater at 15º/sec. No differences in muscle activation at any velocity or muscle action for BF were identified. We conclude that muscle recruitment while training with a 60% 1RM load is maximized at a velocity of 60º/s during ECC activity and 15 or 30º/sec during CON

The Murphy-Good plot: a better method of analysing field emission data

Measured field electron emission (FE) current-voltage Im(Vm) data are traditionally analysed via Fowler-Nordheim (FN) plots, as ln{Im/(Vm)**2} vs 1/Vm. These have been used since 1929, because in 1928 FN predicted they would be linear. In the 1950s, a mistake in FN's thinking was found. Corrected theory by Murphy and Good (MG) made theoretical FN plots slightly curved. This causes difficulties when attempting to extract precise values of emission characterization parameters from straight lines fitted to experimental FN plots. Improved mathematical understanding, from 2006 onwards, has now enabled a new FE data-plot form, the "Murphy-Good plot". This plots ln{Im/(Vm)**(2-({\eta}/6)} vs 1/Vm, where {\eta} depends only on local work function. Modern ("21st century") MG theory predicts that a theoretical MG plot should be "almost exactly" straight. This makes precise extraction of well-defined characterization parameters from ideal I_m(V_m) data much easier. This article gives the theory needed to extract characterization parameters from MG plots, setting it within the framework of wider difficulties in interpreting FE Im(Vm) data (among them, use of the "planar emission approximation"). Careful use of MG plots could also help remedy other problems in FE technological literature. It is argued MG plots should now supersede FN plots.Comment: Intended articl

Investigation of Visual Management Cases in Construction by an Analytical Framework from Manufacturing

Along with the progress of globalization, speed and efficiency have become more critical for any industry than ever before. In this sense, the concept and methods of lean management, promoting these performances, have been deployed from manufacturing, its origin industry, to other industries. This paper deals with this management style in the construction industry, called lean construction. In particular, visual management (VM) as one effective tool in this scheme is focused on. A number of VM cases, 306 in total, was collected from both construction and manufacturing sites and investigated by the so-called 5W1H analytical framework developed in the manufacturing industry. Obtained results suggest that the VM cases in construction have common attributes such as purpose and location, target to attain, users’ attributes, timing to use and elemental technologies for case development. A comparison analysis of the VM cases from construction and those from manufacturing was also carried out, for a mutual transfer of this technology between these industries

In Vitro Stability of Phytase from Recombinant Bacteria E. Coli BL21 (DE3) EAS1-AMP

The objective of the research was to inquire the Km, Vm, activity, intracellular phytase stability exposed to pH variation, temperature variation and protease (pepsin and pancreas) in vitro. The phytase was produced from recombinant bacteria E. coli BL21(DE3) EAS1-AMP using 1.5 mM IPTG as inducer. Intracellular enzyme was extracted via freeze shock and centrifugation. Pure enzyme was acquired through NI-NTA agarose column. The enzyme was then tested for Km, Vm, phytase activity and stability against pH, temperature and protease. Treatment levels for stability against protease were P0: without protease, P1: addition of pepsin, P2: addition of pepsin and pancreas, and the data were statistically analyzed using analysis of variance of one-way Completely Randomized Design. Crude intracellular phytase had Vm 6.39 υM/sec, Km 34.82 υM, and 277 units activity. Intracellular phytas was stable at pH 4–6 and 0–550 C. Protease level influenced the activity of intracellular phytase (P<0.05). Intracellular phytase was stable against pepsin but not pancreas. Keywords: Km, Vm, activity, intracellular phytase, pH, temperature, protease