Unraveling the Global Teleconnections of Indian Summer Monsoon Clouds: Expedition from CMIP5 to CMIP6

We have analyzed the teleconnection of total cloud fraction (TCF) with global sea surface temperature (SST) in multi-model ensembles (MME) of the fifth and sixth Coupled Model Intercomparison Projects (CMIP5 and CMIP6). CMIP6-MME has a more robust and realistic teleconnection (TCF and global SST) pattern over the extra-tropics (R ~0.43) and North Atlantic (R ~0.39) region, which in turn resulted in improvement of rainfall bias over the Asian summer monsoon (ASM) region. CMIP6-MME can better reproduce the mean TCF and have reduced dry (wet) rainfall bias on land (ocean) over the ASM region. CMIP6-MME has improved the biases of seasonal mean rainfall, TCF, and outgoing longwave radiation (OLR) over the Indian Summer Monsoon (ISM) region by ~40%, ~45%, and ~31%, respectively, than CMIP5-MME and demonstrates better spatial correlation with observation/reanalysis. Results establish the credibility of the CMIP6 models and provide a scientific basis for improving the seasonal prediction of ISM.Comment: 12 pages, 4 main figures, 2 supplementary figure

Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction

Acknowledgments The authors would like to thank the Scottish Universities Life Sciences Alliance (SULSA) for their support.Peer reviewedPublisher PD

Systems biology in animal sciences

Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract understanding from these data of biological processes and animal traits are not yet frequently used. This paper aims to explain what systems biology is and which areas of animal sciences could benefit from systems biology approaches. Systems biology aims to understand whole biological systems working as a unit, rather than investigating their individual components. Therefore, systems biology can be considered a holistic approach, as opposed to reductionism. The recently developed ‘omics’ technologies enable biological sciences to characterize the molecular components of life with ever increasing speed, yielding vast amounts of data. However, biological functions do not follow from the simple addition of the properties of system components, but rather arise from the dynamic interactions of these components. Systems biology combines statistics, bioinformatics and mathematical modeling to integrate and analyze large amounts of data in order to extract a better understanding of the biology from these huge data sets and to predict the behavior of biological systems. A ‘system’ approach and mathematical modeling in biological sciences are not new in itself, as they were used in biochemistry, physiology and genetics long before the name systems biology was coined. However, the present combination of mass biological data and of computational and modeling tools is unprecedented and truly represents a major paradigm shift in biology. Significant advances have been made using systems biology approaches, especially in the field of bacterial and eukaryotic cells and in human medicine. Similarly, progress is being made with ‘system approaches’ in animal sciences, providing exciting opportunities to predict and modulate animal traits

The impact of spike timing variability on the signal-encoding performance of neural spiking models

It remains unclear whether the variability of neuronal spike trains in vivo arises due to biological noise sources or represents highly precise encoding of temporally varying synaptic input signals. Determining the variability of spike timing can provide fundamental insights into the nature of strategies used in the brain to represent and transmit information in the form of discrete spike trains. In this study, we employ a signal estimation paradigm to determine how variability in spike timing affects encoding of random time-varying signals. We assess this for two types of spiking models: an integrate-and-fire model with random threshold and a more biophysically realistic stochastic ion channel model. Using the coding fraction and mutual information as information-theoretic measures, we quantify the efficacy of optimal linear decoding of random inputs from the model outputs and study the relationship between efficacy and variability in the output spike train. Our findings suggest that variability does not necessarily hinder signal decoding for the biophysically plausible encoders examined and that the functional role of spiking variability depends intimately on the nature of the encoder and the signal processing task; variability can either enhance or impede decoding performance

Trust and Trustworthiness in Procurement Contracts with Retainage

When product quality is unverifiable by third parties, enforceable contracts that condition price upon quality are not feasible. If higher quality is also costly to deliver, moral hazard by sellers flourishes, particularly when procurement is via a competitive auction process. Retainage is a contractual mechanism that presents a solution to the third-party unverifiability problem, by setting aside a portion of the purchase price. After delivery, the buyer has sole discretion over the amount of retainage money that is released to the seller. While generally a feasible contract form to implement, retainage introduces a moral hazard for the buyer. We use laboratory experiments to investigate how and when retainage might be successfully used to facilitate trust and trustworthiness in procurement contracts. We observe that retainage induces a significant improvement in product quality when there are some trustworthy buyers in the population, consistent with a model of fair payment norms that we develop. This improvement is realized at the cost of increased buyer-seller profit inequalities. We also observe that at high levels of retainage, there is a welfare-decreasing market unraveling in which sellers do not bid on contracts. Our results imply that retainage incentives can mitigate the tension between competition and cooperation arising from reverse auctions, but only at appropriate levels of retainage

Anti-correlated hard X-ray time lags in Galactic black hole sources

We investigate the accretion disk geometry in Galactic black hole sources by measuring the time delay between soft and hard X-ray emissions. Similar to the recent discoveries of anti-correlated hard X-ray time lags in Cyg X-3 and GRS 1915+105, we find that the hard X-rays are anti-correlated with soft X-rays with a significant lag in another source: XTE J1550-564. We also find the existence of pivoting in the model independent X-ray spectrum during these observations. We investigate time-resolved X-ray spectral parameters and find that the variation in these parameters is consistent with the idea of a truncated accretion disk. The QPO frequency, which is a measure of the size of truncated accretion disk, too changes indicating that the geometric size of the hard X-ray emitting region changes along with the spectral pivoting and soft X-ray flux. Similar kind of delay is also noticed in 4U 1630-47.Comment: 14 pages, 7 figures, accepted for publication in Ap

Novelty of product innovation : the role of different networks

In the current competitive scenario, firms are driven to introduce products with a higher degree of novelty. Consequently, there is a growing need to understand the critical success factors behind radical innovation. Specifically, this work empirically and theoretically analyses the role of different types of collaborative networks in achieving product innovation and, more precisely, the degree of novelty. Using a longitudinal data of Spanish manufacturing firms, our results show that the continuity on the co-operative strategy, the type of partner and the diversity of collaborative networks are critical factors in achieving a higher degree of novelty in product innovatio

Biophotonic Tools in Cell and Tissue Diagnostics.

In order to maintain the rapid advance of biophotonics in the U.S. and enhance our competitiveness worldwide, key measurement tools must be in place. As part of a wide-reaching effort to improve the U.S. technology base, the National Institute of Standards and Technology sponsored a workshop titled "Biophotonic tools for cell and tissue diagnostics." The workshop focused on diagnostic techniques involving the interaction between biological systems and photons. Through invited presentations by industry representatives and panel discussion, near- and far-term measurement needs were evaluated. As a result of this workshop, this document has been prepared on the measurement tools needed for biophotonic cell and tissue diagnostics. This will become a part of the larger measurement road-mapping effort to be presented to the Nation as an assessment of the U.S. Measurement System. The information will be used to highlight measurement needs to the community and to facilitate solutions