18,476 research outputs found
Validating a network hub in leukaemia stem cells
No abstract available
Deducing topology of protein-protein interaction networks from experimentally measured sub-networks.
BackgroundProtein-protein interaction networks are commonly sampled using yeast two hybrid approaches. However, whether topological information reaped from these experimentally-measured sub-networks can be extrapolated to complete protein-protein interaction networks is unclear.ResultsBy analyzing various experimental protein-protein interaction datasets, we found that they are not random samples of the parent networks. Based on the experimental bait-prey behaviors, our computer simulations show that these non-random sampling features may affect the topological information. We tested the hypothesis that a core sub-network exists within the experimentally sampled network that better maintains the topological characteristics of the parent protein-protein interaction network. We developed a method to filter the experimentally sampled network to result in a core sub-network that more accurately reflects the topology of the parent network. These findings have fundamental implications for large-scale protein interaction studies and for our understanding of the behavior of cellular networks.ConclusionThe topological information from experimental measured networks network as is may not be the correct source for topological information about the parent protein-protein interaction network. We define a core sub-network that more accurately reflects the topology of the parent network
Network Sampling: From Static to Streaming Graphs
Network sampling is integral to the analysis of social, information, and
biological networks. Since many real-world networks are massive in size,
continuously evolving, and/or distributed in nature, the network structure is
often sampled in order to facilitate study. For these reasons, a more thorough
and complete understanding of network sampling is critical to support the field
of network science. In this paper, we outline a framework for the general
problem of network sampling, by highlighting the different objectives,
population and units of interest, and classes of network sampling methods. In
addition, we propose a spectrum of computational models for network sampling
methods, ranging from the traditionally studied model based on the assumption
of a static domain to a more challenging model that is appropriate for
streaming domains. We design a family of sampling methods based on the concept
of graph induction that generalize across the full spectrum of computational
models (from static to streaming) while efficiently preserving many of the
topological properties of the input graphs. Furthermore, we demonstrate how
traditional static sampling algorithms can be modified for graph streams for
each of the three main classes of sampling methods: node, edge, and
topology-based sampling. Our experimental results indicate that our proposed
family of sampling methods more accurately preserves the underlying properties
of the graph for both static and streaming graphs. Finally, we study the impact
of network sampling algorithms on the parameter estimation and performance
evaluation of relational classification algorithms
Quantitative toxicity prediction using topology based multi-task deep neural networks
The understanding of toxicity is of paramount importance to human health and
environmental protection. Quantitative toxicity analysis has become a new
standard in the field. This work introduces element specific persistent
homology (ESPH), an algebraic topology approach, for quantitative toxicity
prediction. ESPH retains crucial chemical information during the topological
abstraction of geometric complexity and provides a representation of small
molecules that cannot be obtained by any other method. To investigate the
representability and predictive power of ESPH for small molecules, ancillary
descriptors have also been developed based on physical models. Topological and
physical descriptors are paired with advanced machine learning algorithms, such
as deep neural network (DNN), random forest (RF) and gradient boosting decision
tree (GBDT), to facilitate their applications to quantitative toxicity
predictions. A topology based multi-task strategy is proposed to take the
advantage of the availability of large data sets while dealing with small data
sets. Four benchmark toxicity data sets that involve quantitative measurements
are used to validate the proposed approaches. Extensive numerical studies
indicate that the proposed topological learning methods are able to outperform
the state-of-the-art methods in the literature for quantitative toxicity
analysis. Our online server for computing element-specific topological
descriptors (ESTDs) is available at http://weilab.math.msu.edu/TopTox/Comment: arXiv admin note: substantial text overlap with arXiv:1703.1095
PersLay: A Neural Network Layer for Persistence Diagrams and New Graph Topological Signatures
Persistence diagrams, the most common descriptors of Topological Data
Analysis, encode topological properties of data and have already proved pivotal
in many different applications of data science. However, since the (metric)
space of persistence diagrams is not Hilbert, they end up being difficult
inputs for most Machine Learning techniques. To address this concern, several
vectorization methods have been put forward that embed persistence diagrams
into either finite-dimensional Euclidean space or (implicit) infinite
dimensional Hilbert space with kernels. In this work, we focus on persistence
diagrams built on top of graphs. Relying on extended persistence theory and the
so-called heat kernel signature, we show how graphs can be encoded by
(extended) persistence diagrams in a provably stable way. We then propose a
general and versatile framework for learning vectorizations of persistence
diagrams, which encompasses most of the vectorization techniques used in the
literature. We finally showcase the experimental strength of our setup by
achieving competitive scores on classification tasks on real-life graph
datasets
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