RECENT CNN-BASED TECHNIQUES FOR BREAST CANCER HISTOLOGY IMAGE CLASSIFICATION

Histology images are extensively used by pathologists to assess abnormalities and detect malignancy in breast tissues. On the other hand, Convolutional Neural Networks (CNN) are by far, the privileged models for image classification and interpretation. Based on these two facts, we surveyed the recent CNN-based methods for breast cancer histology image analysis. The survey focuses on two major issues usually faced by CNN-based methods namely the design of an appropriate CNN architecture and the lack of a sufficient labelled dataset for training the model. Regarding the design of the CNN architecture, methods examining breast histology images adopt three main approaches: Designing manually from scratch the CNN architecture, using pre-trained models and adopting an automatic architecture design. Methods addressing the lack of labelled datasets are grouped into four categories: methods using pre-trained models, methods using data augmentation, methods adopting weakly supervised learning and those adopting feedforward filter learning. Research works from each category and reported performance are presented in this paper. We conclude the paper by indicating some future research directions related to the analysis of histology images

Conceptual data sampling for breast cancer histology image classification

Data analytics have become increasingly complicated as the amount of data has increased. One technique that is used to enable data analytics in large datasets is data sampling, in which a portion of the data is selected to preserve the data characteristics for use in data analytics. In this paper, we introduce a novel data sampling technique that is rooted in formal concept analysis theory. This technique is used to create samples reliant on the data distribution across a set of binary patterns. The proposed sampling technique is applied in classifying the regions of breast cancer histology images as malignant or benign. The performance of our method is compared to other classical sampling methods. The results indicate that our method is efficient and generates an illustrative sample of small size. It is also competing with other sampling methods in terms of sample size and sample quality represented in classification accuracy and F1 measure

A transfer learning‐based system for grading breast invasive ductal carcinoma

© 2022 The Authors. IET Image Processing published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. This is an open access article under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/Breast carcinoma is a sort of malignancy that begins in the breast. Breast malignancy cells generally structure a tumour that can routinely be seen on an x‐ray or felt like a lump. Despite advances in screening, treatment, and observation that have improved patient endurance rates, breast carcinoma is the most regularly analyzed malignant growth and the subsequent driving reason for malignancy mortality among ladies. Invasive ductal carcinoma is the most boundless breast malignant growth with about 80% of all analyzed cases. It has been found from numerous types of research that artificial intelligence has tremendous capabilities, which is why it is used in various sectors, especially in the healthcare domain. In the initial phase of the medical field, mammography is used for diagnosis, and finding cancer in the case of a dense breast is challenging. The evolution of deep learning and applying the same in the findings are helpful for earlier tracking and medication. The authors have tried to utilize the deep learning concepts for grading breast invasive ductal carcinoma using Transfer Learning in the present work. The authors have used five transfer learning approaches here, namely VGG16, VGG19, InceptionReNetV2, DenseNet121, and DenseNet201 with 50 epochs in the Google Colab platform which has a single 12GB NVIDIA Tesla K80 graphical processing unit (GPU) support that can be used up to 12 h continuously. The dataset used for this work can be openly accessed from http://databiox.com. The experimental results that the authors have received regarding the algorithm's accuracy are as follows: VGG16 with 92.5%, VGG19 with 89.77%, InceptionReNetV2 with 84.46%, DenseNet121 with 92.64%, DenseNet201 with 85.22%. From the experimental results, it is clear that the DenseNet121 gives the maximum accuracy in terms of cancer grading, whereas the InceptionReNetV2 has minimal accuracy.Peer reviewe

Analysis of Signal Decomposition and Stain Separation methods for biomedical applications

Nowadays, the biomedical signal processing and classification and medical image interpretation play an essential role in the detection and diagnosis of several human diseases. The problem of high variability and heterogeneity of information, which is extracted from digital data, can be addressed with signal decomposition and stain separation techniques which can be useful approaches to highlight hidden patterns or rhythms in biological signals and specific cellular structures in histological color images, respectively. This thesis work can be divided into two macro-sections. In the first part (Part I), a novel cascaded RNN model based on long short-term memory (LSTM) blocks is presented with the aim to classify sleep stages automatically. A general workflow based on single-channel EEG signals is developed to enhance the low performance in staging N1 sleep without reducing the performances in the other sleep stages (i.e. Wake, N2, N3 and REM). In the same context, several signal decomposition techniques and time-frequency representations are deployed for the analysis of EEG signals. All extracted features are analyzed by using a novel correlation-based timestep feature selection and finally the selected features are fed to a bidirectional RNN model. In the second part (Part II), a fully automated method named SCAN (Stain Color Adaptive Normalization) is proposed for the separation and normalization of staining in digital pathology. This normalization system allows to standardize digitally, automatically and in a few seconds, the color intensity of a tissue slide with respect to that of a target image, in order to improve the pathologist’s diagnosis and increase the accuracy of computer-assisted diagnosis (CAD) systems. Multiscale evaluation and multi-tissue comparison are performed for assessing the robustness of the proposed method. In addition, a stain normalization based on a novel mathematical technique, named ICD (Inverse Color Deconvolution) is developed for immunohistochemical (IHC) staining in histopathological images. In conclusion, the proposed techniques achieve satisfactory results compared to state-of-the-art methods in the same research field. The workflow proposed in this thesis work and the developed algorithms can be employed for the analysis and interpretation of other biomedical signals and for digital medical image analysis

A transfer learning-based system for grading breast invasive ductal carcinoma

Breast carcinoma is a sort of malignancy that begins in the breast. Breast malignancy cells generally structure a tumour that can routinely be seen on an x-ray or felt like a lump. Despite advances in screening, treatment, and observation that have improved patient endurance rates, breast carcinoma is the most regularly analyzed malignant growth and the subsequent driving reason for malignancy mortality among ladies. Invasive ductal carcinoma is the most boundless breast malignant growth with about 80% of all analyzed cases. It has been found from numerous types of research that artificial intelligence has tremendous capabilities, which is why it is used in various sectors, especially in the healthcare domain. In the initial phase of the medical field, mammography is used for diagnosis, and finding cancer in the case of a dense breast is challenging. The evolution of deep learning and applying the same in the findings are helpful for earlier tracking and medication. The authors have tried to utilize the deep learning concepts for grading breast invasive ductal carcinoma using Transfer Learning in the present work. The authors have used five transfer learning approaches here, namely VGG16, VGG19, InceptionReNetV2, DenseNet121, and DenseNet201 with 50 epochs in the Google Colab platform which has a single 12GB NVIDIA Tesla K80 graphical processing unit (GPU) support that can be used up to 12 h continuously. The dataset used for this work can be openly accessed from http://databiox.com. The experimental results that the authors have received regarding the algorithm's accuracy are as follows: VGG16 with 92.5%, VGG19 with 89.77%, InceptionReNetV2 with 84.46%, DenseNet121 with 92.64%, DenseNet201 with 85.22%. From the experimental results, it is clear that the DenseNet121 gives the maximum accuracy in terms of cancer grading, whereas the InceptionReNetV2 has minimal accuracy

Texture-based Deep Neural Network for Histopathology Cancer Whole Slide Image (WSI) Classification

Automatic histopathological Whole Slide Image (WSI) analysis for cancer classification has been highlighted along with the advancements in microscopic imaging techniques. However, manual examination and diagnosis with WSIs is time-consuming and tiresome. Recently, deep convolutional neural networks have succeeded in histopathological image analysis. In this paper, we propose a novel cancer texture-based deep neural network (CAT-Net) that learns scalable texture features from histopathological WSIs. The innovation of CAT-Net is twofold: (1) capturing invariant spatial patterns by dilated convolutional layers and (2) Reducing model complexity while improving performance. Moreover, CAT-Net can provide discriminative texture patterns formed on cancerous regions of histopathological images compared to normal regions. The proposed method outperformed the current state-of-the-art benchmark methods on accuracy, precision, recall, and F1 score