54,537 research outputs found
Inviwo -- A Visualization System with Usage Abstraction Levels
The complexity of today's visualization applications demands specific
visualization systems tailored for the development of these applications.
Frequently, such systems utilize levels of abstraction to improve the
application development process, for instance by providing a data flow network
editor. Unfortunately, these abstractions result in several issues, which need
to be circumvented through an abstraction-centered system design. Often, a high
level of abstraction hides low level details, which makes it difficult to
directly access the underlying computing platform, which would be important to
achieve an optimal performance. Therefore, we propose a layer structure
developed for modern and sustainable visualization systems allowing developers
to interact with all contained abstraction levels. We refer to this interaction
capabilities as usage abstraction levels, since we target application
developers with various levels of experience. We formulate the requirements for
such a system, derive the desired architecture, and present how the concepts
have been exemplary realized within the Inviwo visualization system.
Furthermore, we address several specific challenges that arise during the
realization of such a layered architecture, such as communication between
different computing platforms, performance centered encapsulation, as well as
layer-independent development by supporting cross layer documentation and
debugging capabilities
SUBIC: A Supervised Bi-Clustering Approach for Precision Medicine
Traditional medicine typically applies one-size-fits-all treatment for the
entire patient population whereas precision medicine develops tailored
treatment schemes for different patient subgroups. The fact that some factors
may be more significant for a specific patient subgroup motivates clinicians
and medical researchers to develop new approaches to subgroup detection and
analysis, which is an effective strategy to personalize treatment. In this
study, we propose a novel patient subgroup detection method, called Supervised
Biclustring (SUBIC) using convex optimization and apply our approach to detect
patient subgroups and prioritize risk factors for hypertension (HTN) in a
vulnerable demographic subgroup (African-American). Our approach not only finds
patient subgroups with guidance of a clinically relevant target variable but
also identifies and prioritizes risk factors by pursuing sparsity of the input
variables and encouraging similarity among the input variables and between the
input and target variable
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