Studying and Modeling the Connection between People's Preferences and Content Sharing

People regularly share items using online social media. However, people's decisions around sharing---who shares what to whom and why---are not well understood. We present a user study involving 87 pairs of Facebook users to understand how people make their sharing decisions. We find that even when sharing to a specific individual, people's own preference for an item (individuation) dominates over the recipient's preferences (altruism). People's open-ended responses about how they share, however, indicate that they do try to personalize shares based on the recipient. To explain these contrasting results, we propose a novel process model of sharing that takes into account people's preferences and the salience of an item. We also present encouraging results for a sharing prediction model that incorporates both the senders' and the recipients' preferences. These results suggest improvements to both algorithms that support sharing in social media and to information diffusion models.Comment: CSCW 201

Characterizing and Predicting Email Deferral Behavior

Email triage involves going through unhandled emails and deciding what to do with them. This familiar process can become increasingly challenging as the number of unhandled email grows. During a triage session, users commonly defer handling emails that they cannot immediately deal with to later. These deferred emails, are often related to tasks that are postponed until the user has more time or the right information to deal with them. In this paper, through qualitative interviews and a large-scale log analysis, we study when and what enterprise email users tend to defer. We found that users are more likely to defer emails when handling them involves replying, reading carefully, or clicking on links and attachments. We also learned that the decision to defer emails depends on many factors such as user's workload and the importance of the sender. Our qualitative results suggested that deferring is very common, and our quantitative log analysis confirms that 12% of triage sessions and 16% of daily active users had at least one deferred email on weekdays. We also discuss several deferral strategies such as marking emails as unread and flagging that are reported by our interviewees, and illustrate how such patterns can be also observed in user logs. Inspired by the characteristics of deferred emails and contextual factors involved in deciding if an email should be deferred, we train a classifier for predicting whether a recently triaged email is actually deferred. Our experimental results suggests that deferral can be classified with modest effectiveness. Overall, our work provides novel insights about how users handle their emails and how deferral can be modeled

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma

Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total, 396 low- and high-risk primary tumors were analyzed, of which 87 were profiled using methyl-CpG-binding domain (MBD) sequencing for differential methylation analysis between prognostic patient groups. Subsequently, methylation-specific PCR (MSP) assays were developed for 78 top-ranking differentially methylated regions and tested on two independent cohorts of 132 and 177 samples, respectively. Further, a new statistical framework was used to identify a robust set of MSP assays of which the methylation score (i.e. the percentage of methylated assays) allows accurate outcome prediction. Survival analyses were performed on the individual target level, as well as on the combined multimarker signature. As a result of the differential DNA methylation assessment by MBD sequencing, 58 of the 78 MSP assays were designed in regions previously unexplored in neuroblastoma, and 36 are located in non-promoter or non-coding regions. In total, 5 individual MSP assays (located in CCDC177, NXPH1, lnc-MRPL3-2, lnc-TREX1-1 and one on a region from chromosome 8 with no further annotation) predict event-free survival and 4 additional assays (located in SPRED3, TNFAIP2, NPM2 and CYYR1) also predict overall survival. Furthermore, a robust 58-marker methylation signature predicting overall and event-free survival was established. In conclusion, this study encompasses the largest DNA methylation biomarker study in neuroblastoma so far. We identified and independently validated several novel prognostic biomarkers, as well as a prognostic 58-marker methylation signature

Understanding Chat Messages for Sticker Recommendation in Messaging Apps

Stickers are popularly used in messaging apps such as Hike to visually express a nuanced range of thoughts and utterances to convey exaggerated emotions. However, discovering the right sticker from a large and ever expanding pool of stickers while chatting can be cumbersome. In this paper, we describe a system for recommending stickers in real time as the user is typing based on the context of the conversation. We decompose the sticker recommendation (SR) problem into two steps. First, we predict the message that the user is likely to send in the chat. Second, we substitute the predicted message with an appropriate sticker. Majority of Hike's messages are in the form of text which is transliterated from users' native language to the Roman script. This leads to numerous orthographic variations of the same message and makes accurate message prediction challenging. To address this issue, we learn dense representations of chat messages employing character level convolution network in an unsupervised manner. We use them to cluster the messages that have the same meaning. In the subsequent steps, we predict the message cluster instead of the message. Our approach does not depend on human labelled data (except for validation), leading to fully automatic updation and tuning pipeline for the underlying models. We also propose a novel hybrid message prediction model, which can run with low latency on low-end phones that have severe computational limitations. Our described system has been deployed for more than $6$ months and is being used by millions of users along with hundreds of thousands of expressive stickers