Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis

[EN] An in-body sensor network is that in which at least one of the sensors is located inside the human body. Such wireless in-body sensors are used mainly in medical applications, collecting and monitoring important parameters for health and disease treatment. IEEE Standard 802.15.6-2012 for wireless body area networks (WBANs) considers in-body communications in the Medical Implant Communications Service (MICS) band. Nevertheless, high-data-rate communications are not feasible at the MICS band because of its narrow occupied bandwidth. In this framework, ultrawideband (UWB) systems have emerged as a potential solution for in-body highdata-rate communications because of their miniaturization capabilities and low power consumption.This work was supported by the Programa de Ayudas de Investigación y Desarrollo (PAID-01-16) at the Universitat Politècnica de València, Spain; by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R); and by the European FEDER funds. It was also funded by the European Union’s H2020:MSCA:ITN program for the Wireless In-Body Environ-ment Communication–WiBEC project under grant 675353.Garcia-Pardo, C.; Andreu-Estellés, C.; Fornés Leal, A.; Castelló-Palacios, S.; Pérez-Simbor, S.; Barbi, M.; Vallés Lluch, A.... (2018). Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis. IEEE Antennas and Propagation Magazine. 60(3):19-33. https://doi.org/10.1109/MAP.2018.2818458S193360

Wideband Electromagnetic Body Phantoms for the Evaluation of Wireless Communications in the Microwave Spectrum

[ES] La constante evolución de la tecnología y la búsqueda de nuevas aplicaciones que mejoren la vida de las personas ha llevado a la incorporación de estas tecnologías en el organismo. Las redes inalámbricas de área corporal (WBAN) son un buen ejemplo de esto, que consisten en redes de comunicaciones ubicadas en el propio cuerpo, tanto en la superficie como implantadas en su interior mediante el uso de dispositivos inalámbricos. Estas redes utilizan el cuerpo humano como medio de transmisión, por lo que debe evaluarse la influencia del mismo sobre la propagación. Además, las nuevas generaciones de comunicaciones móviles se están moviendo hacia el uso de frecuencias cada vez más altas, como las ondas milimétricas, que son más sensibles a la presencia de cualquier objeto en el entorno, incluidos los humanos. La investigación y el diseño de antenas y dispositivos que tengan en cuenta el cuerpo humano requiere pruebas en el entorno donde se supone que deben usarse. Los fantomas se convierten en una herramienta para evaluar la transmisión de señales electromagnéticas en un medio equivalente al cuerpo para evitar la experimentación en humanos o animales. Además de eso, se puede estudiar la influencia de estas ondas electromagnéticas sobre los propios tejidos en cuanto a la tasa de absorción específica (SAR).[CA] L'evolució constant de la tecnologia i la recerca de noves aplicacions que milloren la vida de les persones ha portat a la incorporació d'aquestes tecnologies en l'organisme. Les xarxes sense fils d'àrea corporal (WBAN) són un bon exemple d'açò, que consisteixen en xarxes de comunicacions ubicades al propi cos, tant en la superfície com implantades en el seu interior mitjançant l'ús de dispositius sense fils. Aquestes xarxes empren el cos humà com a medi de transmissió, per la qual cosa se n'ha d'avaluar la influència sobre la propagació. A més, les noves generacions de comunicacions mòbils s'estan movent cap a l'ús de freqüències cada vegada més altes, com les ones mil·limètriques, que són més sensibles a la presència de qualsevol objecte en l'entorn, incloent-hi els humans. La investigació i el disseny d'antenes i dispositius que tinguen en compte el cos humà requereix proves en l'entorn on se suposa que han d'usar-se. Els fantomes esdevenen una eina per a avaluar la transmissió de senyals electromagnètics en un medi equivalent al cos per tal d'evitar l'experimentació en humans o animals. A més d'això, es pot estudiar la influència d'aquestes ones electromagnètiques sobre els teixits mateixos en relació amb la taxa d'absorció específica (SAR).[EN] The constant evolution of technology and the search for new applications that improve people's lives has led to the arrival of the incorporation of these technologies in the organism. Wireless body area networks (WBANs) are a good example of this, consisting of communications networks located in the body itself, both on the surface and implanted inside it through the use of wireless devices. These networks use the human body as the transmitting medium, so its influence over the propagation has to be assessed. Besides, new generations of mobile communications are moving towards the use of higher frequencies, as the millimetre waves, which are more sensitive to the presence of any object in the environment, including humans. The research and design of antennas and devices that take into account the human body requires testing in the environment where these are supposed to be used. Phantoms become a tool for evaluating the transmission of electromagnetic signals in a body-equivalent medium in order to avoid experimentation on humans or animals. In addition to that, the influence of these electromagnetic waves over the tissues themselves can be studied with regard to the specific absorption rate (SAR).This thesis has been possible thanks to the funding contribution of the Universitat Polit`ecnica de Val`encia through the PAID-01-16 programme. This work was also supported by the UPV-IIS La Fe programme (STUDER, 2016 and EMOTE, 2017). The research stay was supported by the European Union’s Erasmus+ funding programme under a traineeship grant.Castelló Palacios, S. (2019). Wideband Electromagnetic Body Phantoms for the Evaluation of Wireless Communications in the Microwave Spectrum [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/13218

Non-Invasive Picosecond Pulse System for Electrostimulation

Picosecond pulsed electric fields have been shown to have stimulatory effects, such as calcium influx, activation of action potential, and membrane depolarization, on biological cells. Because the pulse duration is so short, it has been hypothesized that the pulses permeate a cell and can directly affect intracellular cell structures by bypassing the shielding of the membrane. This provides an opportunity for studying new biophysics. Furthermore, radiating picosecond pulses can be efficiently done by a compact antenna because the antenna size is comparable to the pulse width. However, all of the previous bioelectric studies regarding picosecond pulses have been conducted in vitro, using electrodes. There is not yet a device which can non-invasively deliver picosecond-pulsed electric fields to neurological tissue for therapeutic applications. It is unclear whether a radiated electric field at a given penetration depth can reach the threshold to cause biological effects. In this dissertation, a picosecond- pulsed electric field system designed for the electrosimulation of neural cells is presented. This begins with the design of an ultra-wideband biconical dielectric rod antenna. It consists of a dielectrically loaded V-conical launcher which feeds a cylindrical waveguide. The waveguide then transitions into a taper, which acts like a lens to focus the energy in the tissue target. To describe the antenna delivery of picosecond pulses to tissues, the initial performance was simulated using a 3-layer tissue model and then a human head model. The final model was shown to effectively deliver pulses of 11.5 V/m to the brain for a 1 V input. The spot size of the stimulation is on the order of 1 cm. The electric field was able to penetrate to a depth of 2 cm, which is equal to the pulse width of a 200 ps pulse. The antenna was constructed and characterized in free space in time domain and in frequency domain. The experimental results have a good agreement with the simulation. The ultimate biological application relies on adequate electric field. To reach a threshold electric field for effective stimulation, the antenna should be driven by a high voltage, picosecond-pulsed power supply, which, in our case, consists of a nanosecond charging transformer, a parallel-plate transmission line, and a picosecond discharging switch. This transformer was used to charge a parallel-plate transmission line, with the antenna as the load. To generate pulses with a rise time of hundreds of picoseconds, an oil switch with a millimeter gap was used. For the charging, a dual resonance pulse transformer was designed and constructed. The novel aspect of this transformer is has a fast charge time. It was shown to be capable of producing over 100 kV voltages in less than 100 ns. After the closing of the peaking switch and the picosecond rise time generation, the antenna was able to create an electric field of 600 V/cm in the air at a distance of 3 cm. This field was comparable to the simulation. Higher voltage operation was met with dielectric breakdown across the insulation layer that separates the high voltage side and the ground side. Before the designed antenna is used in vivo, it is critical to determine the biological effect of picosecond pulses. This is especially important if we focus on stimulatory effects, which require that the electric field intensity be close to the range that the antenna system can deliver. Toward that end, neural stem cells were chosen to study for the proliferation, metabolism, and gene expression. Instead of using the antenna, the electrodes were used to deliver the pulses to the cells. In order to treat enough cells for downstream analyses, the electrodes were mounted on a 3-D printer head, which could be moved freely and could be controlled accurately by programming. The results show that pulses on the order of 20 kV/cm affect the proliferation, metabolism, and gene expression of both neural and mesenchymal stem cells, without reducing viability. In general, we came to the conclusion that picosecond pulses can be a useful stimulus for a variety of applications, but the possibility of using antennas to directly stimulate tissue functions relies on the development of a pulsed power system, high voltage insulation, and antenna material

Development Of An Accurate Benchmarking System For Microwave Breast Imaging

This thesis is a discussion of the design and implementation of benchmarking system for microwave imaging systems. The current benchmarking tools for microwave imaging setups are not adaptable. A novel method for of the development of a dielectric phantom using regression analysis is presented. This is followed by a discussion of the design of a novel sensor for the purpose of in vivo dielectric properties measurements. The goal is to provide information for microwave tomography algorithms and phantom development based on in vivo dielectric properties of breast tissues Through the progress of this research two major novel advances have been made toward producing a better microwave imaging benchmark. First, a technique for systematically developing a breast phantom using regression analysis has been developed. This defines a process for researchers to produce a phantom quickly and easily, avoiding the simple trial and error development techniques of the past. Secondly, a method for measuring dielectric constant of a material through an embedded sensor was developed. Both advances are very important in producing accurate phantoms, providing in vivo tissue properties for tomography algorithms and designing matching materials for microwave imaging

Miniaturized Antenna Design For Wireless Biomedical Sensors

This thesis is focused on the design and simulation of miniaturized antennas for wireless biomedical sensors. The motivation of the work was to provide a solution for wireless systems that are embedded or placed on the body. Currently, small antennas are on demand to be implanted inside the body or placed closely to the body. The performance of such antennas, gain and efficiency, is affected by the lossy tissues that surround them. The goal of this work was to design antennas that are placed on a living body and integrated with a sensor system implanted in living tissue, to measure the dielectric properties of the tissue. The antenna type that this work was based on is Planar Inverted F Antenna (PIFA). The assumption was that the antenna is placed on skin layer and not embedded inside a tissue layers. A few antennas were designed and simulated. Two major studies were performed. First, an antenna, which was originally proposed in literature for wireless communication systems, was adopted and revised for biomedical applications. The antenna performance while it was on two tissue layers (skin and fat) was studied and optimized. The objective was to understand how miniaturization and the surrounding environment affect the antenna resonance frequency and performance. A second study was performed to design a novel PIFA antenna to improve the performance and reduce the size further

Microwave Imaging for Diagnostic Application

Imaging of the human body makes a significant contribution to the diagnosis and succeeding treatment of diseases. Among the numerous medical imaging methods, microwave imaging (MWI) is an attractive approach for medical applications due to its high potential to produce images of the human body safely with cost-efficiency. A wide range of studies and research has been done with the aim of using the microwave approach for medical applications. The focus of this research is developing MWI algorithms, which is the Huygens Principle (HP) based and to validate the capability of the proposed MWI algorithm to detect skin cancer and bone lesion through phantom measurements. The probability of the HP procedure for skin cancer detection has been investigated through design, and fabrication of a heterogeneous phantom simulating the human forearm having an inclusion mimicking a skin cancer. Ultrawideband (UWB) MWI methods are then applied to the phantom. The S21 parameter measurements are collected in an anechoic chamber environment and processed via HP technique. The tumour is successfully detected after applying appropriate artefact removal procedure. The ability to successfully apply HP to detect and locate a skin cancer type inclusion in a multilayer cylindrical phantom has been verified. The feasibility study of HP-based MWI procedure for bone lesion detection has also been investigated using a dedicated phantom. Validation has been completed through measurements inside the anechoic chamber in the frequency range of 1–3 GHz using one receiving and one transmitting antennas in free space. The identification of the lesion’s presence in different bone layers has been performed on images. The quantification of the obtained images has been performed by introducing parameters such as the resolution and signal-to-clutter ratio (S/C). The impact of different frequencies and bandwidths (in the 1–3 GHz range) in lesion detection has been investigated. The findings showed that the frequency range of 1.5–2.5 GHz offered the best resolution (1.1 cm) and S/C (2.22 on a linear scale). Subtraction between S21 obtained using two slightly displaced transmitting positions has been employed to remove the artefacts; the best artefact removal has been obtained when the spatial displacement was approximately of the same magnitude as the dimension of the lesion. Subsequently, a phantom validation of a low complexity MWI device (based on HP) operating in free space in the 1-6.5 GHz frequency band using two antennas in free space has been applied. Detection has been achieved in both bone fracture lesion and bone marrow lesion scenarios using superimposition of five doublet transmitting positions after applying the rotation subtraction method to remove artefact. A resolution of 5 mm and the S/C (3.35 in linear scale) are achieved which is clearly confirming the advantage of employing multiple transmitting positions on increased detection capability. The finding of this research verifies the dedicated MWI device as a simple, safe and without any X-ray radiation, portable, and low complexity method, which is capable of been successfully used for bone lesion detection. The outcomes of this thesis may pave the way for the construction of a dedicated bone imaging system that in future could be used as a safe diagnostic device even in emergency sites

Extraction of frequency-dependent electrical characteristics of biological tissues using ultra-wideband electromagnetic pulse

There have been many important contributions to imaging for biomedical applications. The most popular methods include X-ray mammography, magnetic resonance imaging (MRI), ultrasound, and most recently, microwave imaging. While the first three of these have been used for biomedical applications for over three decades, microwave imaging has seen many developments over the last few years. This is primarily due to the large contrast in electrical parameters between different body tissues (including differences between healthy and diseased tissues) at microwave frequencies. There are also vast improvements possible for the comfort of the patient undergoing such imaging as compared to mammography. However, there has been no relevant work to date on extraction of the electrical characteristics of tissues within a living patient. Rather, all of the work in the field of microwave imaging has focused on utilizing the vast contrast in electrical parameters to create an image of internal body structures. The electrical properties of human body tissues can be considered as non-magnetic, lossy, frequency-dependent dielectrics in the general case. All that is needed to fully describe these tissues is the frequency-dependent complex relative permittivity. The present work focuses on a unique application of Ultra-Wideband (UWB) radar to extract the frequency-dependent electrical properties of tissues modeled as multiple layers of dielectric regions. By applying an incident pulse to this series of dielectric regions, and by analyzing the reflected signals, the electrical characteristics can be extracted. The results can be expressed in terms of frequency-dependent relative permittivity and conductivity. This work focuses on the time-domain processing to determine the thickness of dielectric regions. Also, a calibration method is proposed to remove interference from the outer dielectric region. Finally, a generalized methodology is proposed to extract the electrical parameters of multiple dielectric regions in the frequency-domain. In all cases, excellent agreement is found between extracted and expected results