Tensegrity and Motor-Driven Effective Interactions in a Model Cytoskeleton

Actomyosin networks are major structural components of the cell. They provide mechanical integrity and allow dynamic remodeling of eukaryotic cells, self-organizing into the diverse patterns essential for development. We provide a theoretical framework to investigate the intricate interplay between local force generation, network connectivity and collective action of molecular motors. This framework is capable of accommodating both regular and heterogeneous pattern formation, arrested coarsening and macroscopic contraction in a unified manner. We model the actomyosin system as a motorized cat's cradle consisting of a crosslinked network of nonlinear elastic filaments subjected to spatially anti-correlated motor kicks acting on motorized (fibril) crosslinks. The phase diagram suggests there can be arrested phase separation which provides a natural explanation for the aggregation and coalescence of actomyosin condensates. Simulation studies confirm the theoretical picture that a nonequilibrium many-body system driven by correlated motor kicks can behave as if it were at an effective equilibrium, but with modified interactions that account for the correlation of the motor driven motions of the actively bonded nodes. Regular aster patterns are observed both in Brownian dynamics simulations at effective equilibrium and in the complete stochastic simulations. The results show that large-scale contraction requires correlated kicking.Comment: 38 pages, 13 figure

Supporting high penetrations of renewable generation via implementation of real-time electricity pricing and demand response

The rollout of smart meters raises the prospect that domestic customer electrical demand can be responsive to changes in supply capacity. Such responsive demand will become increasingly relevant in electrical power systems, as the proportion of weather-dependent renewable generation increases, due to the difficulty and expense of storing electrical energy. One method of providing response is to allow direct control of customer devices by network operators, as in the UK 'Economy 7' and 'White Meter' schemes used to control domestic electrical heating. However, such direct control is much less acceptable for loads such as washing machines, lighting and televisions. This study instead examines the use of real-time pricing of electricity in the domestic sector. This allows customers to be flexible but, importantly, to retain overall control. A simulation methodology for highlighting the potential effects of, and possible problems with, a national implementation of real-time pricing in the UK domestic electricity market is presented. This is done by disaggregating domestic load profiles and then simulating price-based elastic and load-shifting responses. Analysis of a future UK scenario with 15 GW wind penetration shows that during low-wind events, UK peak demand could be reduced by 8-11 GW. This could remove the requirement for 8-11 GW of standby generation with a capital cost of £2.6 to £3.6 billion. Recommended further work is the investigation of improved demand-forecasting and the price-setting strategies. This is a fine balance between giving customers access to plentiful, cheap energy when it is available, but increasing prices just enough to reduce demand to meet the supply capacity when this capacity is limited

Dynamic Pricing, Advanced Metering, and Demand Response in Electricity Markets

Presents an overview and analysis of the possible approaches to bringing an active demand side into electricity markets. Part of a series of research reports that examines energy issues facing California

Energy management in communication networks: a journey through modelling and optimization glasses

The widespread proliferation of Internet and wireless applications has produced a significant increase of ICT energy footprint. As a response, in the last five years, significant efforts have been undertaken to include energy-awareness into network management. Several green networking frameworks have been proposed by carefully managing the network routing and the power state of network devices. Even though approaches proposed differ based on network technologies and sleep modes of nodes and interfaces, they all aim at tailoring the active network resources to the varying traffic needs in order to minimize energy consumption. From a modeling point of view, this has several commonalities with classical network design and routing problems, even if with different objectives and in a dynamic context. With most researchers focused on addressing the complex and crucial technological aspects of green networking schemes, there has been so far little attention on understanding the modeling similarities and differences of proposed solutions. This paper fills the gap surveying the literature with optimization modeling glasses, following a tutorial approach that guides through the different components of the models with a unified symbolism. A detailed classification of the previous work based on the modeling issues included is also proposed

Open-Source, Open-Architecture SoftwarePlatform for Plug-InElectric Vehicle SmartCharging in California

This interdisciplinary eXtensible Building Operating System–Vehicles project focuses on controlling plug-in electric vehicle charging at residential and small commercial settings using a novel and flexible open-source, open-architecture charge communication and control platform. The platform provides smart charging functionalities and benefits to the utility, homes, and businesses.This project investigates four important areas of vehicle-grid integration research, integrating technical as well as social and behavioral dimensions: smart charging user needs assessment, advanced load control platform development and testing, smart charging impacts, benefits to the power grid, and smart charging ratepayer benefits

Distributed Load Testing by Modeling and Simulating User Behavior

Modern human-machine systems such as microservices rely upon agile engineering practices which require changes to be tested and released more frequently than classically engineered systems. A critical step in the testing of such systems is the generation of realistic workloads or load testing. Generated workload emulates the expected behaviors of users and machines within a system under test in order to find potentially unknown failure states. Typical testing tools rely on static testing artifacts to generate realistic workload conditions. Such artifacts can be cumbersome and costly to maintain; however, even model-based alternatives can prevent adaptation to changes in a system or its usage. Lack of adaptation can prevent the integration of load testing into system quality assurance, leading to an incomplete evaluation of system quality. The goal of this research is to improve the state of software engineering by addressing open challenges in load testing of human-machine systems with a novel process that a) models and classifies user behavior from streaming and aggregated log data, b) adapts to changes in system and user behavior, and c) generates distributed workload by realistically simulating user behavior. This research contributes a Learning, Online, Distributed Engine for Simulation and Testing based on the Operational Norms of Entities within a system (LODESTONE): a novel process to distributed load testing by modeling and simulating user behavior. We specify LODESTONE within the context of a human-machine system to illustrate distributed adaptation and execution in load testing processes. LODESTONE uses log data to generate and update user behavior models, cluster them into similar behavior profiles, and instantiate distributed workload on software systems. We analyze user behavioral data having differing characteristics to replicate human-machine interactions in a modern microservice environment. We discuss tools, algorithms, software design, and implementation in two different computational environments: client-server and cloud-based microservices. We illustrate the advantages of LODESTONE through a qualitative comparison of key feature parameters and experimentation based on shared data and models. LODESTONE continuously adapts to changes in the system to be tested which allows for the integration of load testing into the quality assurance process for cloud-based microservices

Comfort-Centered Design of a Lightweight and Backdrivable Knee Exoskeleton

This paper presents design principles for comfort-centered wearable robots and their application in a lightweight and backdrivable knee exoskeleton. The mitigation of discomfort is treated as mechanical design and control issues and three solutions are proposed in this paper: 1) a new wearable structure optimizes the strap attachment configuration and suit layout to ameliorate excessive shear forces of conventional wearable structure design; 2) rolling knee joint and double-hinge mechanisms reduce the misalignment in the sagittal and frontal plane, without increasing the mechanical complexity and inertia, respectively; 3) a low impedance mechanical transmission reduces the reflected inertia and damping of the actuator to human, thus the exoskeleton is highly-backdrivable. Kinematic simulations demonstrate that misalignment between the robot joint and knee joint can be reduced by 74% at maximum knee flexion. In experiments, the exoskeleton in the unpowered mode exhibits 1.03 Nm root mean square (RMS) low resistive torque. The torque control experiments demonstrate 0.31 Nm RMS torque tracking error in three human subjects.Comment: 8 pages, 16figures, Journa