Leveraging Semantic Web Technologies for Managing Resources in a Multi-Domain Infrastructure-as-a-Service Environment

This paper reports on experience with using semantically-enabled network resource models to construct an operational multi-domain networked infrastructure-as-a-service (NIaaS) testbed called ExoGENI, recently funded through NSF's GENI project. A defining property of NIaaS is the deep integration of network provisioning functions alongside the more common storage and computation provisioning functions. Resource provider topologies and user requests can be described using network resource models with common base classes for fundamental cyber-resources (links, nodes, interfaces) specialized via virtualization and adaptations between networking layers to specific technologies. This problem space gives rise to a number of application areas where semantic web technologies become highly useful - common information models and resource class hierarchies simplify resource descriptions from multiple providers, pathfinding and topology embedding algorithms rely on query abstractions as building blocks. The paper describes how the semantic resource description models enable ExoGENI to autonomously instantiate on-demand virtual topologies of virtual machines provisioned from cloud providers and are linked by on-demand virtual connections acquired from multiple autonomous network providers to serve a variety of applications ranging from distributed system experiments to high-performance computing

Enabling Technology in Optical Fiber Communications: From Device, System to Networking

This book explores the enabling technology in optical fiber communications. It focuses on the state-of-the-art advances from fundamental theories, devices, and subsystems to networking applications as well as future perspectives of optical fiber communications. The topics cover include integrated photonics, fiber optics, fiber and free-space optical communications, and optical networking

State of the Art in Dense Monocular Non-Rigid 3D Reconstruction

3D reconstruction of deformable (or non-rigid) scenes from a set of monocular2D image observations is a long-standing and actively researched area ofcomputer vision and graphics. It is an ill-posed inverse problem,since--without additional prior assumptions--it permits infinitely manysolutions leading to accurate projection to the input 2D images. Non-rigidreconstruction is a foundational building block for downstream applicationslike robotics, AR/VR, or visual content creation. The key advantage of usingmonocular cameras is their omnipresence and availability to the end users aswell as their ease of use compared to more sophisticated camera set-ups such asstereo or multi-view systems. This survey focuses on state-of-the-art methodsfor dense non-rigid 3D reconstruction of various deformable objects andcomposite scenes from monocular videos or sets of monocular views. It reviewsthe fundamentals of 3D reconstruction and deformation modeling from 2D imageobservations. We then start from general methods--that handle arbitrary scenesand make only a few prior assumptions--and proceed towards techniques makingstronger assumptions about the observed objects and types of deformations (e.g.human faces, bodies, hands, and animals). A significant part of this STAR isalso devoted to classification and a high-level comparison of the methods, aswell as an overview of the datasets for training and evaluation of thediscussed techniques. We conclude by discussing open challenges in the fieldand the social aspects associated with the usage of the reviewed methods.<br

State of the Art in Dense Monocular Non-Rigid 3D Reconstruction

3D reconstruction of deformable (or non-rigid) scenes from a set of monocular 2D image observations is a long-standing and actively researched area of computer vision and graphics. It is an ill-posed inverse problem, since--without additional prior assumptions--it permits infinitely many solutions leading to accurate projection to the input 2D images. Non-rigid reconstruction is a foundational building block for downstream applications like robotics, AR/VR, or visual content creation. The key advantage of using monocular cameras is their omnipresence and availability to the end users as well as their ease of use compared to more sophisticated camera set-ups such as stereo or multi-view systems. This survey focuses on state-of-the-art methods for dense non-rigid 3D reconstruction of various deformable objects and composite scenes from monocular videos or sets of monocular views. It reviews the fundamentals of 3D reconstruction and deformation modeling from 2D image observations. We then start from general methods--that handle arbitrary scenes and make only a few prior assumptions--and proceed towards techniques making stronger assumptions about the observed objects and types of deformations (e.g. human faces, bodies, hands, and animals). A significant part of this STAR is also devoted to classification and a high-level comparison of the methods, as well as an overview of the datasets for training and evaluation of the discussed techniques. We conclude by discussing open challenges in the field and the social aspects associated with the usage of the reviewed methods.Comment: 25 page

Machine Learning Small Molecule Properties in Drug Discovery

Machine learning (ML) is a promising approach for predicting small molecule properties in drug discovery. Here, we provide a comprehensive overview of various ML methods introduced for this purpose in recent years. We review a wide range of properties, including binding affinities, solubility, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity). We discuss existing popular datasets and molecular descriptors and embeddings, such as chemical fingerprints and graph-based neural networks. We highlight also challenges of predicting and optimizing multiple properties during hit-to-lead and lead optimization stages of drug discovery and explore briefly possible multi-objective optimization techniques that can be used to balance diverse properties while optimizing lead candidates. Finally, techniques to provide an understanding of model predictions, especially for critical decision-making in drug discovery are assessed. Overall, this review provides insights into the landscape of ML models for small molecule property predictions in drug discovery. So far, there are multiple diverse approaches, but their performances are often comparable. Neural networks, while more flexible, do not always outperform simpler models. This shows that the availability of high-quality training data remains crucial for training accurate models and there is a need for standardized benchmarks, additional performance metrics, and best practices to enable richer comparisons between the different techniques and models that can shed a better light on the differences between the many techniques.Comment: 46 pages, 1 figur

Resource Management in Softwarized Networks

Communication networks are undergoing a major transformation through softwarization, which is changing the way networks are designed, operated, and managed. Network Softwarization is an emerging paradigm where software controls the treatment of network flows, adds value to these flows by software processing, and orchestrates the on-demand creation of customized networks to meet the needs of customer applications. Software-Defined Networking (SDN), Network Function Virtualization (NFV), and Network Virtualization are three cornerstones of the overall transformation trend toward network softwarization. Together, they are empowering network operators to accelerate time-to-market for new services, diversify the supply chain for networking hardware and software, bringing the benefits of agility, economies of scale, and flexibility of cloud computing to networks. The enhanced programmability enabled by softwarization creates unique opportunities for adapting network resources in support of applications and users with diverse requirements. To effectively leverage the flexibility provided by softwarization and realize its full potential, it is of paramount importance to devise proper mechanisms for allocating resources to different applications and users and for monitoring their usage over time. The overarching goal of this dissertation is to advance state-of-the-art in how resources are allocated and monitored and build the foundation for effective resource management in softwarized networks. Specifically, we address four resource management challenges in three key enablers of network softwarization, namely SDN, NFV, and network virtualization. First, we challenge the current practice of realizing network services with monolithic software network functions and propose a microservice-based disaggregated architecture enabling finer-grained resource allocation and scaling. Then, we devise optimal solutions and scalable heuristics for establishing virtual networks with guaranteed bandwidth and guaranteed survivability against failure on multi-layer IP-over-Optical and single-layer IP substrate network, respectively. Finally, we propose adaptive sampling mechanisms for balancing the overhead of softwarized network monitoring and the accuracy of the network view constructed from monitoring data