24,202 research outputs found

    Statistical methods of SNP data analysis with applications

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    Various statistical methods important for genetic analysis are considered and developed. Namely, we concentrate on the multifactor dimensionality reduction, logic regression, random forests and stochastic gradient boosting. These methods and their new modifications, e.g., the MDR method with "independent rule", are used to study the risk of complex diseases such as cardiovascular ones. The roles of certain combinations of single nucleotide polymorphisms and external risk factors are examined. To perform the data analysis concerning the ischemic heart disease and myocardial infarction the supercomputer SKIF "Chebyshev" of the Lomonosov Moscow State University was employed

    Parameters estimation for spatio-temporal maximum entropy distributions: application to neural spike trains

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    We propose a numerical method to learn Maximum Entropy (MaxEnt) distributions with spatio-temporal constraints from experimental spike trains. This is an extension of two papers [10] and [4] who proposed the estimation of parameters where only spatial constraints were taken into account. The extension we propose allows to properly handle memory effects in spike statistics, for large sized neural networks.Comment: 34 pages, 33 figure
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