A multiscale modelling approach to understand atherosclerosis formation: A patient-specific case study in the aortic bifurcation

Atherogenesis, the formation of plaques in the wall of blood vessels, starts as a result of lipid accumulation (low-density lipoprotein cholesterol) in the vessel wall. Such accumulation is related to the site of endothelial mechanotransduction, the endothelial response to mechanical stimuli and haemodynamics, which determines biochemical processes regulating the vessel wall permeability. This interaction between biomechanical and biochemical phenomena is complex, spanning different biological scales and is patient-specific, requiring tools able to capture such mathematical and biological complexity in a unified framework. Mathematical models offer an elegant and efficient way of doing this, by taking into account multifactorial and multiscale processes and mechanisms, in order to capture the fundamentals of plaque formation in individual patients. In this study, a mathematical model to understand plaque and calcification locations is presented: this model provides a strong interpretability and physical meaning through a multiscale, complex index or metric (the penetration site of low-density lipoprotein cholesterol, expressed as volumetric flux). Computed tomography scans of the aortic bifurcation and iliac arteries are analysed and compared with the results of the multifactorial model. The results indicate that the model shows potential to predict the majority of the plaque locations, also not predicting regions where plaques are absent. The promising results from this case study provide a proof of concept that can be applied to a larger patient population

Academic Year 2019-2020 Faculty Excellence Showcase, AFIT Graduate School of Engineering & Management

An excerpt from the Dean\u27s Message: There is no place like the Air Force Institute of Technology (AFIT). There is no academic group like AFIT’s Graduate School of Engineering and Management. Although we run an educational institution similar to many other institutions of higher learning, we are different and unique because of our defense-focused graduate-research-based academic programs. Our programs are designed to be relevant and responsive to national defense needs. Our programs are aligned with the prevailing priorities of the US Air Force and the US Department of Defense. Our faculty team has the requisite critical mass of service-tested faculty members. The unique composition of pure civilian faculty, military faculty, and service-retired civilian faculty makes AFIT truly unique, unlike any other academic institution anywhere

Graduate School of Engineering and Management Catalog 2018-2019

The Graduate Catalog represents the offerings, programs, and requirements in effect at the time of publication

Research and Technology Report: 1997

This volume highlights the most significant results from research and development projects sponsored through NASA's Office of Equal Opportunity Programs, Minority University Research and Education Division, in collaboration with Headquarters Program Offices, during Academic Year 1996-97 and Summer 1996. It includes the work of major multidisciplinary research groups, such as those sponsored under NASA's University Research Centers at Minority Institutions and Institutional Research Awards programs, as well as that of individual principal investigators sponsored under the Faculty Awards for Research or other MUREP programs. It encompasses contributions from 863 students and 388 faculty-level researchers at institutions eligible to compete for MUREP funding, including: Historically Black Colleges and Universities (HBCU), Hispanic-Serving Institutions (HSI), Tribal Colleges and Universities (TCU), and accredited minority colleges or universities with a 50 percent or greater underrepresented minority student enrollment. It stands as a testimony to NASA's response to Executive Orders 12876, 12900, and 13021, which mandate increased Federal support to these classes of institutions. We firmly believe that maintaining America's leadership in aerospace and related areas depends on fully utilizing the talents available at the Nation's minority universities

Air Force Institute of Technology Research Report 2019

This Research Report presents the FY19 research statistics and contributions of the Graduate School of Engineering and Management (EN) at AFIT. AFIT research interests and faculty expertise cover a broad spectrum of technical areas related to USAF needs, as reflected by the range of topics addressed in the faculty and student publications listed in this report. In most cases, the research work reported herein is directly sponsored by one or more USAF or DOD agencies. AFIT welcomes the opportunity to conduct research on additional topics of interest to the USAF, DOD, and other federal organizations when adequate manpower and financial resources are available and/or provided by a sponsor. In addition, AFIT provides research collaboration and technology transfer benefits to the public through Cooperative Research and Development Agreements (CRADAs). Interested individuals may discuss ideas for new research collaborations, potential CRADAs, or research proposals with individual faculty using the contact information in this document

Air Force Institute of Technology Research Report 2015

This report summarizes the research activities of the Air Force Institute of Technology’s Graduate School of Engineering and Management. It describes research interests and faculty expertise; lists student theses/dissertations; identifies research sponsors and contributions; and outlines the procedures for contacting the school. Included in the report are: faculty publications, conference presentations, consultations, and funded research projects. Research was conducted in the areas of Aeronautical and Astronautical Engineering, Electrical Engineering and Electro-Optics, Computer Engineering and Computer Science, Systems Engineering and Management, Operational Sciences, Mathematics, Statistics and Engineering Physics

Air Force Institute of Technology Research Report 2015

This report summarizes the research activities of the Air Force Institute of Technology’s Graduate School of Engineering and Management. It describes research interests and faculty expertise; lists student theses/dissertations; identifies research sponsors and contributions; and outlines the procedures for contacting the school. Included in the report are: faculty publications, conference presentations, consultations, and funded research projects. Research was conducted in the areas of Aeronautical and Astronautical Engineering, Electrical Engineering and Electro-Optics, Computer Engineering and Computer Science, Systems Engineering and Management, Operational Sciences, Mathematics, Statistics and Engineering Physics

The University of Michigan Department of Nuclear Engineering and Radiological Sciences: A History

https://deepblue.lib.umich.edu/bitstream/2027.42/145451/1/2018_UM_Nuclear_Engineering_History.pd