1,120 research outputs found
Machine Intelligence for Advanced Medical Data Analysis: Manifold Learning Approach
In the current work, linear and non-linear manifold learning techniques, specifically Principle Component Analysis (PCA) and Laplacian Eigenmaps, are studied in detail. Their applications in medical image and shape analysis are investigated.
In the first contribution, a manifold learning-based multi-modal image registration technique is developed, which results in a unified intensity system through intensity transformation between the reference and sensed images. The transformation eliminates intensity variations in multi-modal medical scans and hence facilitates employing well-studied mono-modal registration techniques. The method can be used for registering multi-modal images with full and partial data.
Next, a manifold learning-based scale invariant global shape descriptor is introduced. The proposed descriptor benefits from the capability of Laplacian Eigenmap in dealing with high dimensional data by introducing an exponential weighting scheme. It eliminates the limitations tied to the well-known cotangent weighting scheme, namely dependency on triangular mesh representation and high intra-class quality of 3D models.
In the end, a novel descriptive model for diagnostic classification of pulmonary nodules is presented. The descriptive model benefits from structural differences between benign and malignant nodules for automatic and accurate prediction of a candidate nodule. It extracts concise and discriminative features automatically from the 3D surface structure of a nodule using spectral features studied in the previous work combined with a point cloud-based deep learning network.
Extensive experiments have been conducted and have shown that the proposed algorithms based on manifold learning outperform several state-of-the-art methods. Advanced computational techniques with a combination of manifold learning and deep networks can play a vital role in effective healthcare delivery by providing a framework for several fundamental tasks in image and shape processing, namely, registration, classification, and detection of features of interest
Learning shape correspondence with anisotropic convolutional neural networks
Establishing correspondence between shapes is a fundamental problem in
geometry processing, arising in a wide variety of applications. The problem is
especially difficult in the setting of non-isometric deformations, as well as
in the presence of topological noise and missing parts, mainly due to the
limited capability to model such deformations axiomatically. Several recent
works showed that invariance to complex shape transformations can be learned
from examples. In this paper, we introduce an intrinsic convolutional neural
network architecture based on anisotropic diffusion kernels, which we term
Anisotropic Convolutional Neural Network (ACNN). In our construction, we
generalize convolutions to non-Euclidean domains by constructing a set of
oriented anisotropic diffusion kernels, creating in this way a local intrinsic
polar representation of the data (`patch'), which is then correlated with a
filter. Several cascades of such filters, linear, and non-linear operators are
stacked to form a deep neural network whose parameters are learned by
minimizing a task-specific cost. We use ACNNs to effectively learn intrinsic
dense correspondences between deformable shapes in very challenging settings,
achieving state-of-the-art results on some of the most difficult recent
correspondence benchmarks
Robust Temporally Coherent Laplacian Protrusion Segmentation of 3D Articulated Bodies
In motion analysis and understanding it is important to be able to fit a
suitable model or structure to the temporal series of observed data, in order
to describe motion patterns in a compact way, and to discriminate between them.
In an unsupervised context, i.e., no prior model of the moving object(s) is
available, such a structure has to be learned from the data in a bottom-up
fashion. In recent times, volumetric approaches in which the motion is captured
from a number of cameras and a voxel-set representation of the body is built
from the camera views, have gained ground due to attractive features such as
inherent view-invariance and robustness to occlusions. Automatic, unsupervised
segmentation of moving bodies along entire sequences, in a temporally-coherent
and robust way, has the potential to provide a means of constructing a
bottom-up model of the moving body, and track motion cues that may be later
exploited for motion classification. Spectral methods such as locally linear
embedding (LLE) can be useful in this context, as they preserve "protrusions",
i.e., high-curvature regions of the 3D volume, of articulated shapes, while
improving their separation in a lower dimensional space, making them in this
way easier to cluster. In this paper we therefore propose a spectral approach
to unsupervised and temporally-coherent body-protrusion segmentation along time
sequences. Volumetric shapes are clustered in an embedding space, clusters are
propagated in time to ensure coherence, and merged or split to accommodate
changes in the body's topology. Experiments on both synthetic and real
sequences of dense voxel-set data are shown. This supports the ability of the
proposed method to cluster body-parts consistently over time in a totally
unsupervised fashion, its robustness to sampling density and shape quality, and
its potential for bottom-up model constructionComment: 31 pages, 26 figure
Graph Laplacian for Image Anomaly Detection
Reed-Xiaoli detector (RXD) is recognized as the benchmark algorithm for image
anomaly detection; however, it presents known limitations, namely the
dependence over the image following a multivariate Gaussian model, the
estimation and inversion of a high-dimensional covariance matrix, and the
inability to effectively include spatial awareness in its evaluation. In this
work, a novel graph-based solution to the image anomaly detection problem is
proposed; leveraging the graph Fourier transform, we are able to overcome some
of RXD's limitations while reducing computational cost at the same time. Tests
over both hyperspectral and medical images, using both synthetic and real
anomalies, prove the proposed technique is able to obtain significant gains
over performance by other algorithms in the state of the art.Comment: Published in Machine Vision and Applications (Springer
Landmark Localization, Feature Matching and Biomarker Discovery from Magnetic Resonance Images
The work presented in this thesis proposes several methods that can be roughly divided into three different categories: I) landmark localization in medical images, II) feature matching for image registration,
and III) biomarker discovery in neuroimaging.
The first part deals with the identification of anatomical landmarks. The motivation stems from the fact that the manual identification and labeling of these landmarks is very time consuming and prone to observer errors, especially when large datasets must be analyzed. In this thesis we present three methods to tackle this challenge: A landmark descriptor based on local self-similarities (SS), a subspace building framework based on manifold learning and a sparse coding landmark descriptor based on data-specific learned dictionary basis.
The second part of this thesis deals with finding matching features between a pair of images. These matches can be used to perform a registration between them. Registration is a powerful tool that allows mapping images in a common space in order to aid in their analysis. Accurate registration can be challenging to achieve using intensity based registration algorithms. Here, a framework is proposed for learning correspondences in pairs of images by matching SS features and random sample and consensus (RANSAC) is employed as a robust model estimator to learn a deformation model based on feature matches.
Finally, the third part of the thesis deals with biomarker discovery using machine learning. In this section a framework for feature extraction from learned low-dimensional subspaces that represent inter-subject
variability is proposed. The manifold subspace is built using data-driven regions of interest (ROI). These regions are learned via sparse regression, with stability selection. Also, probabilistic distribution models for
different stages in the disease trajectory are estimated for different class populations in the low-dimensional manifold and used to construct a probabilistic scoring function.Open Acces
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