14 research outputs found

    Papers to Appear in Forthcoming Issues

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    Learning About Meetings

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    Most people participate in meetings almost every day, multiple times a day. The study of meetings is important, but also challenging, as it requires an understanding of social signals and complex interpersonal dynamics. Our aim this work is to use a data-driven approach to the science of meetings. We provide tentative evidence that: i) it is possible to automatically detect when during the meeting a key decision is taking place, from analyzing only the local dialogue acts, ii) there are common patterns in the way social dialogue acts are interspersed throughout a meeting, iii) at the time key decisions are made, the amount of time left in the meeting can be predicted from the amount of time that has passed, iv) it is often possible to predict whether a proposal during a meeting will be accepted or rejected based entirely on the language (the set of persuasive words) used by the speaker

    Distinguishing Hidden Markov Chains

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    Hidden Markov Chains (HMCs) are commonly used mathematical models of probabilistic systems. They are employed in various fields such as speech recognition, signal processing, and biological sequence analysis. We consider the problem of distinguishing two given HMCs based on an observation sequence that one of the HMCs generates. More precisely, given two HMCs and an observation sequence, a distinguishing algorithm is expected to identify the HMC that generates the observation sequence. Two HMCs are called distinguishable if for every ε>0\varepsilon > 0 there is a distinguishing algorithm whose error probability is less than ε\varepsilon. We show that one can decide in polynomial time whether two HMCs are distinguishable. Further, we present and analyze two distinguishing algorithms for distinguishable HMCs. The first algorithm makes a decision after processing a fixed number of observations, and it exhibits two-sided error. The second algorithm processes an unbounded number of observations, but the algorithm has only one-sided error. The error probability, for both algorithms, decays exponentially with the number of processed observations. We also provide an algorithm for distinguishing multiple HMCs. Finally, we discuss an application in stochastic runtime verification.Comment: This is the full version of a LICS'16 pape

    Linkage disequilibrium based genotype calling from low-coverage shotgun sequencing reads

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    Background Recent technology advances have enabled sequencing of individual genomes, promising to revolutionize biomedical research. However, deep sequencing remains more expensive than microarrays for performing whole-genome SNP genotyping. Results In this paper we introduce a new multi-locus statistical model and computationally efficient genotype calling algorithms that integrate shotgun sequencing data with linkage disequilibrium (LD) information extracted from reference population panels such as Hapmap or the 1000 genomes project. Experiments on publicly available 454, Illumina, and ABI SOLiD sequencing datasets suggest that integration of LD information results in genotype calling accuracy comparable to that of microarray platforms from sequencing data of low-coverage. A software package implementing our algorithm, released under the GNU General Public License, is available at http://dna.engr.uconn.edu/software/GeneSeq/. Conclusions Integration of LD information leads to significant improvements in genotype calling accuracy compared to prior LD-oblivious methods, rendering low-coverage sequencing as a viable alternative to microarrays for conducting large-scale genome-wide association studies
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