Understanding Protein Mechanism With Computational Approaches

Proteins, which are essentially linear polymers of amino acid residues, perform a tremendous variety of functions, including catalyzing biochemical reactions, replicating genetic information, transporting molecules, constructing cell architecture, and transducing signals in the microscopic milieu of cells and the interstitial fluid. Such linear chains of residues undergo complicated folding processes to form biologically active 3-dimensional structures as they are translated. Since the first protein structure of myoglobin was determined using X-ray crystallography in 1958, biophysicists have been making continuous efforts to understand the associations between protein structures and their functions. Unfortunately, only static snapshots and limited dynamics of proteins at atomic-level resolution are available with the experimental approaches developed so far, which precludes a complete biophysical and temporal understanding of protein mechanisms in the context of the microscopic biochemical processes in which they operate. Molecular dynamics (MD) simulations have been introduced as a computational approach to acquire information about the full dynamics of molecular systems, especially proteins. The method allows for sampling of the time evolution of proteins in the form of trajectories (a collection of frames containing precise coordinates), provides quantitative insights into how proteins function, and has been widely used as an essential tool to understand protein mechanisms. Specialized computer hardware developed in recent years, coupled with improved software implementations, have greatly accelerated MD simulations. A single GPU-attached cluster is capable of producing microsecond-length trajectories in reasonable amounts of time. As the timescales of MD simulations keep increasing, it becomes more challenging to analyze long trajectories. Tasks such as identifying the conformational states of proteins by clustering frames in trajectories are usually resolved with unsupervised machine learning algorithms. The quality of their results directly affects the answers of many biophysical questions, which implies that using an appropriate analytical method for a particular MD aim is as important as a sufficient sampling of protein conformations. In the first two chapters of this dissertation, the basic theory of MD simulations is introduced together with several important unsupervised learning algorithms we used in investigating specific biophysical problems, which target the issues of dimensionality reduction and clustering. These algorithms include the novel data-driven and generative clustering algorithm we developed based on adversarial autoencoders. Then we present our investigation on the conformational dynamics and ion transport mechanism of the sodium iodide symporter, which could be considered as an example of adopting MD and unsupervised learning approaches to understand the working mechanisms of proteins. In the last chapter, we introduce an application of computational structural biology to large-scale drug screening

Controllability of linear parabolic equations and systems

Maste

A COMPARISON BETWEEN MOTIVATIONS AND PERSONALITY TRAITS IN RELIGIOUS TOURISTS AND CRUISE SHIP TOURISTS

The purpose of this paper is to analyze the motivations and the personality traits that characterize tourists who choose religious travels versus cruises. Participating in the research were 683 Italian tourists (345 males and 338 females, age range 18–63 years); 483 who went to a pilgrimage travel and 200 who chose a cruise ship in the Mediterranean Sea. Both groups of tourists completed the Travel Motivation Scale and the Big Five Questionnaire. Results show that different motivations and personality traits characterize the different types of tourists and, further, that motivations for traveling are predicted by specific —some similar, other divergent— personality trait

2007-2008 UNM CATALOG

Course catalog for the years 2007-2008.https://digitalrepository.unm.edu/course_catalogs/1022/thumbnail.jp

2006-2007 UNM CATALOG

Course catalog for the years 2006-2007.https://digitalrepository.unm.edu/course_catalogs/1011/thumbnail.jp

Proceedings of the 9th MIT/ONR workshop on C3 Systems, held at Naval Postgraduate School and Hilton Inn Resort Hotel, Monterey, California June 2 through June 5, 1986

GRSN 627729"December 1986."Includes bibliographical references and index.Sponsored by Massachusetts Institute of Technology, Laboratory for Information and Decision Systems, Cambridge, Mass., with support from the Office of Naval Research. ONR/N00014-77-C-0532(NR041-519) Sponsored in cooperation with IEEE Control Systems Society, Technical Committee on C.edited by Michael Athans, Alexander H. Levis

Proceedings of the 21st International Congress of Aesthetics, Possible Worlds of Contemporary Aesthetics Aesthetics Between History, Geography and Media

The Faculty of Architecture, University of Belgrade and the Society for Aesthetics of Architecture and Visual Arts of Serbia (DEAVUS) are proud to be able to organize the 21st ICA Congress on “Possible Worlds of Contemporary Aesthetics: Aesthetics Between History, Geography and Media”. We are proud to announce that we received over 500 submissions from 56 countries, which makes this Congress the greatest gathering of aestheticians in this region in the last 40 years. The ICA 2019 Belgrade aims to map out contemporary aesthetics practices in a vivid dialogue of aestheticians, philosophers, art theorists, architecture theorists, culture theorists, media theorists, artists, media entrepreneurs, architects, cultural activists and researchers in the fields of humanities and social sciences. More precisely, the goal is to map the possible worlds of contemporary aesthetics in Europe, Asia, North and South America, Africa and Australia. The idea is to show, interpret and map the unity and diverseness in aesthetic thought, expression, research, and philosophies on our shared planet. Our goal is to promote a dialogue concerning aesthetics in those parts of the world that have not been involved with the work of the International Association for Aesthetics to this day. Global dialogue, understanding and cooperation are what we aim to achieve. That said, the 21st ICA is the first Congress to highlight the aesthetic issues of marginalised regions that have not been fully involved in the work of the IAA. This will be accomplished, among others, via thematic round tables discussing contemporary aesthetics in East Africa and South America. Today, aesthetics is recognized as an important philosophical, theoretical and even scientific discipline that aims at interpreting the complexity of phenomena in our contemporary world. People rather talk about possible worlds or possible aesthetic regimes rather than a unique and consistent philosophical, scientific or theoretical discipline

21st International Congress of Aesthetics, Possible Worlds of Contemporary Aesthetics Aesthetics Between History, Geography and Media, Book of Abstracts

The Faculty of Architecture, University of Belgrade and the Society for Aesthetics of Architecture and Visual Arts of Serbia (DEAVUS) are proud to be able to organize the 21st ICA Congress on “Possible Worlds of Contemporary Aesthetics: Aesthetics Between History, Geography and Media”. We are proud to announce that we received over 500 submissions from 56 countries, which makes this Congress the greatest gathering of aestheticians in this region in the last 40 years. The ICA 2019 Belgrade aims to map out contemporary aesthetics practices in a vivid dialogue of aestheticians, philosophers, art theorists, architecture theorists, culture theorists, media theorists, artists, media entrepreneurs, architects, cultural activists and researchers in the fields of humanities and social sciences. More precisely, the goal is to map the possible worlds of contemporary aesthetics in Europe, Asia, North and South America, Africa and Australia. The idea is to show, interpret and map the unity and diverseness in aesthetic thought, expression, research, and philosophies on our shared planet. Our goal is to promote a dialogue concerning aesthetics in those parts of the world that have not been involved with the work of the International Association for Aesthetics to this day. Global dialogue, understanding and cooperation are what we aim to achieve. That said, the 21st ICA is the first Congress to highlight the aesthetic issues of marginalised regions that have not been fully involved in the work of the IAA. This will be accomplished, among others, via thematic round tables discussing contemporary aesthetics in East Africa and South America. Today, aesthetics is recognized as an important philosophical, theoretical and even scientific discipline that aims at interpreting the complexity of phenomena in our contemporary world. People rather talk about possible worlds or possible aesthetic regimes rather than a unique and consistent philosophical, scientific or theoretical discipline