Analytical study of the effect of recombination on evolution via DNA shuffling

We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. We also briefly discuss finite population size corrections

On the analysis and interpretation of inhomogeneous quadratic forms as receptive fields

In this paper we introduce some mathematical and numerical tools to analyze and interpret inhomogeneous quadratic forms. The resulting characterization is in some aspects similar to that given by experimental studies of cortical cells, making it particularly suitable for application to second-order approximations and theoretical models of physiological receptive fields. We first discuss two ways of analyzing a quadratic form by visualizing the coefficients of its quadratic and linear term directly and by considering the eigenvectors of its quadratic term. We then present an algorithm to compute the optimal excitatory and inhibitory stimuli, i.e. the stimuli that maximize and minimize the considered quadratic form, respectively, given a fixed energy constraint. The analysis of the optimal stimuli is completed by considering their invariances, which are the transformations to which the quadratic form is most insensitive. We introduce a test to determine which of these are statistically significant. Next we propose a way to measure the relative contribution of the quadratic and linear term to the total output of the quadratic form. Furthermore, we derive simpler versions of the above techniques in the special case of a quadratic form without linear term and discuss the analysis of such functions in previous theoretical and experimental studies. In the final part of the paper we show that for each quadratic form it is possible to build an equivalent two-layer neural network, which is compatible with (but more general than) related networks used in some recent papers and with the energy model of complex cells. We show that the neural network is unique only up to an arbitrary orthogonal transformation of the excitatory and inhibitory subunits in the first layer

Optimal choice of an exchange rate regime: a critical literature review

This paper set out to review the main theories and empirical methods employed in selecting an appropriate exchange rate regime.In order to achieve this, the paper is organized as follows : Section 2 introduces the distinct classifications of exchange regimes(de jure exchange rate regimes versus the facto exchange rate regimes), and the different theoretical approaches which illustrate how an optimal exchange rate regime is determined . Despite their initial popularity, the theoretical considerations have not escaped criticism.Section 3 reviews the criticism of these theories.A conclusion is provided in Section 4

A spatial mixed Poisson framework for combination of excess-of-loss and proportional reinsurance contracts

In this paper a purely theoretical reinsurance model is presented, where the reinsurance contract is assumed to be simultaneously of an excess-of-loss and of a proportional type. The stochastic structure of the set of pairs (claim’s arrival time, claim’s size) is described by a Spatial Mixed Poisson Process. By using an invariance property of the Spatial Mixed Poisson Processes, we estimate the amount that the ceding company obtains in a fixed time interval in force of the reinsurance contract