28,868 research outputs found
Reducing the Barrier to Entry of Complex Robotic Software: a MoveIt! Case Study
Developing robot agnostic software frameworks involves synthesizing the
disparate fields of robotic theory and software engineering while
simultaneously accounting for a large variability in hardware designs and
control paradigms. As the capabilities of robotic software frameworks increase,
the setup difficulty and learning curve for new users also increase. If the
entry barriers for configuring and using the software on robots is too high,
even the most powerful of frameworks are useless. A growing need exists in
robotic software engineering to aid users in getting started with, and
customizing, the software framework as necessary for particular robotic
applications. In this paper a case study is presented for the best practices
found for lowering the barrier of entry in the MoveIt! framework, an
open-source tool for mobile manipulation in ROS, that allows users to 1)
quickly get basic motion planning functionality with minimal initial setup, 2)
automate its configuration and optimization, and 3) easily customize its
components. A graphical interface that assists the user in configuring MoveIt!
is the cornerstone of our approach, coupled with the use of an existing
standardized robot model for input, automatically generated robot-specific
configuration files, and a plugin-based architecture for extensibility. These
best practices are summarized into a set of barrier to entry design principles
applicable to other robotic software. The approaches for lowering the entry
barrier are evaluated by usage statistics, a user survey, and compared against
our design objectives for their effectiveness to users
Australasian Journal of Philosophy 1947â2016: a retrospective using citation and social network analyses
In anticipation of the journalâs centenary in 2027 this paper provides a citation network analysis of all available citation and publication data of the Australasian Journal of Philosophy (1923â2017). A total of 2,353 academic articles containing 21,772 references were collated and analyzed. This includes 175 articles that contained author-submitted keywords, 415 publisher-tagged keywords and 519 articles that had abstracts. Results initially focused on finding the most published authors, most cited articles and most cited authors within the journal, followed by most discussed topics and emerging patterns using keywords and abstracts. The analysis then proceeded to apply social network analysis using Kumu© â a visualization platform for mapping systems and relationships using large datasets. Analysis reveals topic clusters both unique to the journal, and inclusive of the journalâs history. Results from this analysis reaffirm the journalâs continuing focus on topics in traditional analytic philosophy such as morality, epistemology and knowledge, whilst also featuring topics associated with logic and paradox. This paper presents a new approach to analysing and understanding the historic and emerging topics of interest to the journal, and its readership. This has never previously been done for single philosophy journal. This is historically important given the journalâs forthcoming centenary
A checklist for choosing between R packages in ecology and evolution
The open source and free programming language R is a phenomenal mechanism to address a multiplicity of challenges in ecology and evolution. It is also a complex ecosystem because of the diversity of solutions available to the analyst.
Packages for R enhance and specialize the capacity to explore both niche data/experiments and more common needs. However, the paradox of choice or how we select between many seemingly similar options can be overwhelming and lead to different potential outcomes.
There is extensive choice in ecology and evolution between packages for both fundamental statistics and for more specialized domainâlevel analyses.
Here, we provide a checklist to inform these decisions based on the principles of resilience, need, and integration with scientific workflows for evidence.
It is important to explore choices in any analytical coding environmentânot just Râfor solutions to challenges in ecology and evolution, and document this process because it advances reproducible science, promotes a deeper understand of the scientific evidence, and ensures that the outcomes are correct, representative, and robust.York University Librarie
Novel pathways of heart failure with preserved ejection fraction
INTRODUCTION: Diastolic heart failure (HF) i.e., HF with preserved ejection fraction (HFpEF) accounts for ~50% of all clinical HF presentations; but unlike systolic HF i.e., HF with reduced ejection fraction (HFrEF), there are no evidenced based therapies. Obesity is commonly associated with HFpEF. However, there exist a sub-group of obese patients that exhibit a higher survival rate to HFpEF as compared to average patients. Hypertension is the most important risk factor for HFpEF, with a prevalence of 60-89% reported by large controlled trials, epidemiological studies and HF registries. HFpEF morbidity and mortality rates are staggering: 50-60% 5 year mortality rate, 50% 6 month rehospitalization rate and severe clinical disability. However, there remains an incomplete mechanistic understanding about HFpEF.
OBJECTIVES: We wanted to explore new pathways related to HFpEF in order to better understand the mechamisms behind its pathophysiology. To do so, we first wanted to explore the potential crosstalk between the heart and adipose tissue during HFpEF by analyzing the adipose tissue in our HFpEF model. Secondly, we sought to test the hypothesis that chronic ETA/ETB inhibition with macitentan (mac) modulates pathologic cardiac remodeling in hypertension-induced HFpEF.
METHODS: Mice (20-25 g) were anesthetized, underwent uninephrectomy and received either a continuous infusion of saline (sham) or d-aldosterone (0.3 ug/hour for 4-weeks via osmotic minipumps). All mice were maintained on standard rodent chow and 1.0% sodium chloride drinking water for 4 weeks and then harvested.
Second group of mice underwent the same surgical procedure and infusion. They were maintained on standard chow for 2 weeks and then each group was randomized to chow containing macitentan (30 mg/kg/day, HFpEFmac) or standard rodent chow. After 2 additional weeks, the 4 groups of mice (n=4-8/group) were harvested.
Blood pressure (BP) was obtained weekly. Prior to sacrifice, body weight and echocardiography parameters (total wall thickness (TWT) and relative wall thickness (RWT)) were determined. We also obtained diastolic dysfunction parameters including deceleration time (DT), isovolumetric relaxation time (IVRT), and E/A ratio. Furthermore, we measured organ weight after harvesting the mice and obtained histological images for the adipose tissues collected. Glucose tolerance test and acute cold tolerance test were performed on HFpEF mice to determine their metabolic state.
RESULTS: HFpEF mice developed hypertension, LV hypertrophy, and diastolic dysfunction. Epididymal and inguinal adipose tissue showed significantly reduced weight and adipocyte size. HFpEF mice displayed regular glucose metabolism but were not able to endure a cold tolerance test as their body temperature dropped too low.
After 4 weeks, there was no difference in body weight between sham, HFpEF, shammac and HFpEFmac. As expected HFpEF increased systolic BP (117±14 vs 133±16mmHg; P=NS); macitentan did not lower systolic BP after 2 weeks in either shammac or HFpEFmac. Similarly there was no difference in systolic BP between HFpEF and HFpEFmac. Both kidney and spleen weights were increased in HFpEF but not altered by macitentan therapy. There was no change in lung congestion as measured by wet-dry lung ratio.
HFpEF increased TWT (0.998±0.04 vs. 0.79±0.11 mm; P<0.01 vs. sham) and RWT (0.686± 0.10 vs. 0.476±0.05 mm; P<0.001 vs. sham) but were modulated by macitentan (HFpEF vs. HFpEFmac; P<0.05 and P<0.001, respectively). There was no difference in chamber size between HFpEF and HFpEFmac. Similarly, IVRT, DT, left ventricular ejection fraction were no different between HFpEF and and HFpEFmac. Furthermore E/A ratio was increased in HFpEF but was not affected by macitentan
CONCLUSIONS: Adipose tissue collected from our HFpEF mice displayed a very different phenotype. This demonstrates that inter-tissue communication is definitely occurring between the adipose tissue and the heart. Further research is required to explore what that communication encompasses and how they can be used to improve HFpEF.
Macitentan did not lower systolic BP in sham or mice with HFpEF after the development of hypertension. Diastolic dysfunction, as measured by an increased E/A ratio, was not affected by macitentan. Macitentan significantly modulated TWT and RWT after 2 weeks of therapy. It is thus plausible that macitentan may improve HFpEF by improving adverse cardiac remodeling
Extending the DSE: LOD support and TEI/IIIF integration in EVT
Current digital scholarly editions (DSEs) have the opportunity of evolving to dynamic objects interacting with other Internet-based resources thanks to open frameworks such as IIIF and LOD. This paper showcases and discusses two new functionalities of EVT (Edition Visualization Technology), version 2: one improving the management of named entities (f.i. personal names) through the use of LOD resources such as FOAF and DBpedia; the other, providing integration of the published text with digital images of the textual primary sources accessed from online repositories (e.g. e-codices or digital libraries such as the Vaticana or the Ambrosiana) via the IIIF protocol
Interactive 3D Simulation of Escher-like Impossible Worlds
figures and impossible worlds. Many of his works illustrate mathematical and geometrical concepts such as perspective
and limits. Works by Escher have motivated scientists over the years to discover the mathematical foundations
of his work, ultimately leading to applications that are able to model and render scenes similar to the ones created
by Escher. Presented is an application that is capable of displaying a special class of impossible worlds that have
been created by the artist. The software displays worlds that appear physically correct, but are connected in an impossible
manner, similar to Escherâs Another World II or Relativity. Portal rendering is employed to create real-time
interactive visualizations of such scenes, which can be freely explored by the user
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