When the only way is up: the pitfalls of upward mobility

For over two years, I have been working as an assistant professor at Delft University of Technology, making my way up the hierarchical, academic career ladder

Orientation in upper gastrointestinal endoscopy—the only way is up

BACKGROUND Oesophagogastroduodenoscopy is the gold standard investigation for the upper gastrointestinal (UGI) tract. Orientation during endoscopy is challenging and United Kingdom training focusses on technical competence and procedural safety. The reported location of UGI pathologies is crucial to post-endoscopic planning. AIM To evaluate endoscopists’ ability to spatially orientate themselves within the UGI tract. METHODS A cross sectional descriptive study elicited, using an anonymised survey, the ability of endoscopists to orientate themselves within the UGI tract. The primary outcome was percentage of correct answers from all surveyed; secondary outcomes were percentage of correct answers from experienced vs novice endoscopists. Pearson’s χ2 test was applied to compare groups. RESULTS Of 188 respondents, 86 were experienced endoscopists having completed over 1000 endoscopies. 44.4% of respondents correctly identified the anterior stomach and 47.3% correctly identified the posterior of the second part of the duodenum (D2). Experienced endoscopists were significantly more likely than novice to identify the anterior stomach correctly [61.6% vs 31.3%, X2 (1, n = 188) = 11.10, P = 0.001]. There was no significant difference between the two groups in identifying the posterior of D2. CONCLUSION The majority of endoscopists surveyed were unable to identify key landmarks within the UGI tract. Endoscopic orientation appears to improve with experience yet there are some areas still not well recognised. This has potential considerable impact on post-endoscopic management of patients with posterior duodenal ulcers being more likely to perforate and associated with a higher rebleeding risk. We suggest the development of a consensus statement on endoscopic description

The only way is up: retail format saturation and the demise of the American five and dime store, 1914-1941

We examine a classic ‘wheel of retailing’ episode – the abandonment of the five and dime pricing formula by American variety chains. These switched from a conventional product lifecycle, focusing on cost reduction through standardisation, to a reverse path up the ‘service cost - unit value’ continuum. We show that, rather than reflecting deteriorating managerial acumen, this was a response to the continued imperative for growth following retail format saturation. Firm-specific (rather than format-specific) competitive advantages were too weak for any chain to be confident it could win a within-format price war, making inter-format competition through raising price points more attractive

Towards classification of simple finite dimensional modular Lie superalgebras

A way to construct (conjecturally all) simple finite dimensional modular Lie (super)algebras over algebraically closed fields of characteristic not 2 is offered. In characteristic 2, the method is supposed to give only simple Lie (super)algebras graded by integers and only some of the non-graded ones). The conjecture is backed up with the latest results computationally most difficult of which are obtained with the help of Grozman's software package SuperLie.Comment: 10 page

Superconducting resonators as beam splitters for linear-optics quantum computation

A functioning quantum computer will be a machine that builds up, in a programmable way, nonclassical correlations in a multipartite quantum system. Linear optics quantum computation (LOQC) is an approach for achieving this function that requires only simple, reliable linear optical elements, namely beam splitters and phase shifters. Nonlinear optics is only required in the form of single-photon sources for state initialization, and detectors. However, the latter remain difficult to achieve with high fidelity. A new setting for quantum optics has arisen in circuit quantum electrodynamics (cQED) using superconducting (SC) quantum devices, and opening up the way to LOQC using microwave, rather than visible photons. Much progress is being made in SC qubits and cQED: high-fidelity Fock state generation and qubit measurements provide single photon sources and detection. Here we show that the LOQC toolkit in cQED can be completed with high-fidelity (>99.92%) linear optical elements.Comment: 4 pages, 3 figure

Scientific discovery reloaded

The way scientific discovery has been conceptualized has changed drastically in the last few decades: its relation to logic, inference, methods, and evolution has been deeply reloaded. The ‘philosophical matrix’ moulded by logical empiricism and analytical tradition has been challenged by the ‘friends of discovery’, who opened up the way to a rational investigation of discovery. This has produced not only new theories of discovery (like the deductive, cognitive, and evolutionary), but also new ways of practicing it in a rational and more systematic way. Ampliative rules, methods, heuristic procedures and even a logic of discovery have been investigated, extracted, reconstructed and refined. The outcome is a ‘scientific discovery revolution’: not only a new way of looking at discovery, but also a construction of tools that can guide us to discover something new. This is a very important contribution of philosophy of science to science, as it puts the former in a position not only to interpret what scientists do, but also to provide and improve tools that they can employ in their activity

Kant’s post-1800 Disavowal of the Highest Good Argument for the Existence of God

I have two main goals in this paper. The first is to argue for the thesis that Kant gave up on his highest good argument for the existence of God around 1800. The second is to revive a dialogue about this thesis that died out in the 1960s. The paper is divided into three sections. In the first, I reconstruct Kant’s highest good argument. In the second, I turn to the post-1800 convolutes of Kant’s Opus postumum to discuss his repeated claim that there is only one way to argue for the existence of God, a way which resembles the highest good argument only in taking the moral law as its starting point. In the third, I explain why I do not find the counterarguments to my thesis introduced in the 1960s persuasive