590 research outputs found
Naturalizing institutions: Evolutionary principles and application on the case of money
In recent extensions of the Darwinian paradigm into economics, the replicator-interactor duality looms large. I propose a strictly naturalistic approach to this duality in the context of the theory of institutions, which means that its use is seen as being always and necessarily dependent on identifying a physical realization. I introduce a general framework for the analysis of institutions, which synthesizes Searle's and Aoki's theories, especially with regard to the role of public representations (signs) in the coordination of actions, and the function of cognitive processes that underly rule-following as a behavioral disposition. This allows to conceive institutions as causal circuits that connect the population-level dynamics of interactions with cognitive phenomena on the individual level. Those cognitive phenomena ultimately root in neuronal structures. So, I draw on a critical restatement of the concept of the meme by Aunger to propose a new conceptualization of the replicator in the context of institutions, namely, the replicator is a causal conjunction between signs and neuronal structures which undergirds the dispositions that generate rule-following actions. Signs, in turn, are outcomes of population-level interactions. I apply this framework on the case of money, analyzing the emotions that go along with the use of money, and presenting a stylized account of the emergence of money in terms of the naturalized Searle-Aoki model. In this view, money is a neuronally anchored metaphor for emotions relating with social exchange and reciprocity. Money as a meme is physically realized in a replicator which is a causal conjunction of money artefacts and money emotions. --Generalized Darwinism,institutions,replicator/interactor,Searle,Aoki,naturalism,memes,emotions,money
Mythemesis: The Human Way of Knowing and Believing
Although science, philosophy, literature, and religion each have a different way of formulating explanations, they are all telling stories of why and how. The author describes how the human propensity to seek explanation through narrative can he understood as the product of an embodied mind. He offers a hypothesis ( \"mythemesis\" ) to explain the process and goes on to show that it may provide an opportunity to reduce scientific-religious conflict by transcending the dichotomy between first- and third-person modes of experience
Relative Entropy in Biological Systems
In this paper we review various information-theoretic characterizations of
the approach to equilibrium in biological systems. The replicator equation,
evolutionary game theory, Markov processes and chemical reaction networks all
describe the dynamics of a population or probability distribution. Under
suitable assumptions, the distribution will approach an equilibrium with the
passage of time. Relative entropy - that is, the Kullback--Leibler divergence,
or various generalizations of this - provides a quantitative measure of how far
from equilibrium the system is. We explain various theorems that give
conditions under which relative entropy is nonincreasing. In biochemical
applications these results can be seen as versions of the Second Law of
Thermodynamics, stating that free energy can never increase with the passage of
time. In ecological applications, they make precise the notion that a
population gains information from its environment as it approaches equilibrium.Comment: 20 page
Entraining and copying of temporal correlations in dissociated cultured neurons
Here we used multi-electrode array technology to examine the encoding of temporal information in dissociated hippocampal networks. We demonstrate that two connected populations of neurons can be trained to encode a defined time interval, and this memory trace persists for several hours. We also investigate whether the spontaneous firing activity of a trained network, can act as a template for copying the encoded time interval to a naive network. Such findings are of general significance for understanding fundamental principles of information storage and replicatio
Selectionist and Evolutionary Approaches to Brain Function: A Critical Appraisal
We consider approaches to brain dynamics and function that have been claimed to be Darwinian. These include Edelman’s theory of neuronal group selection, Changeux’s theory of synaptic selection and selective stabilization of pre-representations, Seung’s Darwinian synapse, Loewenstein’s synaptic melioration, Adam’s selfish synapse, and Calvin’s replicating activity patterns. Except for the last two, the proposed mechanisms are selectionist but not truly Darwinian, because no replicators with information transfer to copies and hereditary variation can be identified in them. All of them fit, however, a generalized selectionist framework conforming to the picture of Price’s covariance formulation, which deliberately was not specific even to selection in biology, and therefore does not imply an algorithmic picture of biological evolution. Bayesian models and reinforcement learning are formally in agreement with selection dynamics. A classification of search algorithms is shown to include Darwinian replicators (evolutionary units with multiplication, heredity, and variability) as the most powerful mechanism for search in a sparsely occupied search space. Examples are given of cases where parallel competitive search with information transfer among the units is more efficient than search without information transfer between units. Finally, we review our recent attempts to construct and analyze simple models of true Darwinian evolutionary units in the brain in terms of connectivity and activity copying of neuronal groups. Although none of the proposed neuronal replicators include miraculous mechanisms, their identification remains a challenge but also a great promise
USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator
The nuclear genomes of vertebrates show a highly organized program of DNA replication where GC-rich isochores are replicated early in S-phase, while AT-rich isochores are late replicating. GC-rich regions are gene dense and are enriched for active transcription, suggesting a connection between gene regulation and replication timing. Insulator elements can organize independent domains of gene transcription and are suitable candidates for being key regulators of replication timing. We have tested the impact of inserting a strong replication origin flanked by the β-globin HS4 insulator on the replication timing of naturally late replicating regions in two different avian cell types, DT40 (lymphoid) and 6C2 (erythroid). We find that the HS4 insulator has the capacity to impose a shift to earlier replication. This shift requires the presence of HS4 on both sides of the replication origin and results in an advance of replication timing of the target locus from the second half of S-phase to the first half when a transcribed gene is positioned nearby. Moreover, we find that the USF transcription factor binding site is the key cis-element inside the HS4 insulator that controls replication timing. Taken together, our data identify a combination of cis-elements that might constitute the basic unit of multi-replicon megabase-sized early domains of DNA replication
Quantum fluctuations and life
There have been many claims that quantum mechanics plays a key role in the
origin and/or operation of biological organisms, beyond merely providing the
basis for the shapes and sizes of biological molecules and their chemical
affinities. These range from the suggestion by Schrodinger that quantum
fluctuations produce mutations, to the conjecture by Hameroff and Penrose that
quantum coherence in microtubules is linked to consciousness. I review some of
these claims in this paper, and discuss the serious problem of decoherence. I
advance some further conjectures about quantum information processing in
bio-systems. Some possible experiments are suggested.Comment: 10 pages, no figures, conference pape
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