45,303 research outputs found
Large Scale In Silico Screening on Grid Infrastructures
Large-scale grid infrastructures for in silico drug discovery open
opportunities of particular interest to neglected and emerging diseases. In
2005 and 2006, we have been able to deploy large scale in silico docking within
the framework of the WISDOM initiative against Malaria and Avian Flu requiring
about 105 years of CPU on the EGEE, Auvergrid and TWGrid infrastructures. These
achievements demonstrated the relevance of large-scale grid infrastructures for
the virtual screening by molecular docking. This also allowed evaluating the
performances of the grid infrastructures and to identify specific issues raised
by large-scale deployment.Comment: 14 pages, 2 figures, 2 tables, The Third International Life Science
Grid Workshop, LSGrid 2006, Yokohama, Japan, 13-14 october 2006, to appear in
the proceeding
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Distributed simulation and the grid: Position statements
The Grid provides a new and unrivaled technology for large scale distributed simulation as it enables collaboration and the use of distributed computing resources. This panel paper presents the views of four researchers in the area of Distributed Simulation and the Grid. Together we try to identify the main research issues involved in applying Grid technology to distributed simulation and the key future challenges that need to be solved to achieve this goal. Such challenges include not only technical challenges, but also political ones such as management methodology for the Grid and the development of standards. The benefits of the Grid to end-user simulation modelers also are discussed
IETF standardization in the field of the Internet of Things (IoT): a survey
Smart embedded objects will become an important part of what is called the Internet of Things. However, the integration of embedded devices into the Internet introduces several challenges, since many of the existing Internet technologies and protocols were not designed for this class of devices. In the past few years, there have been many efforts to enable the extension of Internet technologies to constrained devices. Initially, this resulted in proprietary protocols and architectures. Later, the integration of constrained devices into the Internet was embraced by IETF, moving towards standardized IP-based protocols. In this paper, we will briefly review the history of integrating constrained devices into the Internet, followed by an extensive overview of IETF standardization work in the 6LoWPAN, ROLL and CoRE working groups. This is complemented with a broad overview of related research results that illustrate how this work can be extended or used to tackle other problems and with a discussion on open issues and challenges. As such the aim of this paper is twofold: apart from giving readers solid insights in IETF standardization work on the Internet of Things, it also aims to encourage readers to further explore the world of Internet-connected objects, pointing to future research opportunities
InterCloud: Utility-Oriented Federation of Cloud Computing Environments for Scaling of Application Services
Cloud computing providers have setup several data centers at different
geographical locations over the Internet in order to optimally serve needs of
their customers around the world. However, existing systems do not support
mechanisms and policies for dynamically coordinating load distribution among
different Cloud-based data centers in order to determine optimal location for
hosting application services to achieve reasonable QoS levels. Further, the
Cloud computing providers are unable to predict geographic distribution of
users consuming their services, hence the load coordination must happen
automatically, and distribution of services must change in response to changes
in the load. To counter this problem, we advocate creation of federated Cloud
computing environment (InterCloud) that facilitates just-in-time,
opportunistic, and scalable provisioning of application services, consistently
achieving QoS targets under variable workload, resource and network conditions.
The overall goal is to create a computing environment that supports dynamic
expansion or contraction of capabilities (VMs, services, storage, and database)
for handling sudden variations in service demands.
This paper presents vision, challenges, and architectural elements of
InterCloud for utility-oriented federation of Cloud computing environments. The
proposed InterCloud environment supports scaling of applications across
multiple vendor clouds. We have validated our approach by conducting a set of
rigorous performance evaluation study using the CloudSim toolkit. The results
demonstrate that federated Cloud computing model has immense potential as it
offers significant performance gains as regards to response time and cost
saving under dynamic workload scenarios.Comment: 20 pages, 4 figures, 3 tables, conference pape
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