The Church Synthesis Problem with Parameters

For a two-variable formula ψ(X,Y) of Monadic Logic of Order (MLO) the Church Synthesis Problem concerns the existence and construction of an operator Y=F(X) such that ψ(X,F(X)) is universally valid over Nat. B\"{u}chi and Landweber proved that the Church synthesis problem is decidable; moreover, they showed that if there is an operator F that solves the Church Synthesis Problem, then it can also be solved by an operator defined by a finite state automaton or equivalently by an MLO formula. We investigate a parameterized version of the Church synthesis problem. In this version ψ might contain as a parameter a unary predicate P. We show that the Church synthesis problem for P is computable if and only if the monadic theory of is decidable. We prove that the B\"{u}chi-Landweber theorem can be extended only to ultimately periodic parameters. However, the MLO-definability part of the B\"{u}chi-Landweber theorem holds for the parameterized version of the Church synthesis problem

PixelFolder: An Efficient Progressive Pixel Synthesis Network for Image Generation

Pixel synthesis is a promising research paradigm for image generation, which can well exploit pixel-wise prior knowledge for generation. However, existing methods still suffer from excessive memory footprint and computation overhead. In this paper, we propose a progressive pixel synthesis network towards efficient image generation, coined as PixelFolder. Specifically, PixelFolder formulates image generation as a progressive pixel regression problem and synthesizes images by a multi-stage paradigm, which can greatly reduce the overhead caused by large tensor transformations. In addition, we introduce novel pixel folding operations to further improve model efficiency while maintaining pixel-wise prior knowledge for end-to-end regression. With these innovative designs, we greatly reduce the expenditure of pixel synthesis, e.g., reducing 90% computation and 57% parameters compared to the latest pixel synthesis method called CIPS. To validate our approach, we conduct extensive experiments on two benchmark datasets, namely FFHQ and LSUN Church. The experimental results show that with much less expenditure, PixelFolder obtains new state-of-the-art (SOTA) performance on two benchmark datasets, i.e., 3.77 FID and 2.45 FID on FFHQ and LSUN Church, respectively. Meanwhile, PixelFolder is also more efficient than the SOTA methods like StyleGAN2, reducing about 74% computation and 36% parameters, respectively. These results greatly validate the effectiveness of the proposed PixelFolder.Comment: 11 pages, 7 figure

Synthesis of Recursive ADT Transformations from Reusable Templates

Recent work has proposed a promising approach to improving scalability of program synthesis by allowing the user to supply a syntactic template that constrains the space of potential programs. Unfortunately, creating templates often requires nontrivial effort from the user, which impedes the usability of the synthesizer. We present a solution to this problem in the context of recursive transformations on algebraic data-types. Our approach relies on polymorphic synthesis constructs: a small but powerful extension to the language of syntactic templates, which makes it possible to define a program space in a concise and highly reusable manner, while at the same time retains the scalability benefits of conventional templates. This approach enables end-users to reuse predefined templates from a library for a wide variety of problems with little effort. The paper also describes a novel optimization that further improves the performance and scalability of the system. We evaluated the approach on a set of benchmarks that most notably includes desugaring functions for lambda calculus, which force the synthesizer to discover Church encodings for pairs and boolean operations

Synthetic biology—putting engineering into biology

Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we review the case for this emerging discipline. Key aspects of an engineering approach are purpose-orientation, deep insight into the underlying scientific principles, a hierarchy of abstraction including suitable interfaces between and within the levels of the hierarchy, standardization and the separation of design and fabrication. Synthetic biology investigates possibilities to implement these requirements into the process of engineering biological systems. This is illustrated on the DNA level by the implementation of engineering-inspired artificial operations such as toggle switching, oscillating or production of spatial patterns. On the protein level, the functionally self-contained domain structure of a number of proteins suggests possibilities for essentially Lego-like recombination which can be exploited for reprogramming DNA binding domain specificities or signaling pathways. Alternatively, computational design emerges to rationally reprogram enzyme function. Finally, the increasing facility of de novo DNA synthesis—synthetic biology’s system fabrication process—supplies the possibility to implement novel designs for ever more complex systems. Some of these elements have merged to realize the first tangible synthetic biology applications in the area of manufacturing of pharmaceutical compounds.

Interval-based Synthesis

We introduce the synthesis problem for Halpern and Shoham's modal logic of intervals extended with an equivalence relation over time points, abbreviated HSeq. In analogy to the case of monadic second-order logic of one successor, the considered synthesis problem receives as input an HSeq formula phi and a finite set Sigma of propositional variables and temporal requests, and it establishes whether or not, for all possible evaluations of elements in Sigma in every interval structure, there exists an evaluation of the remaining propositional variables and temporal requests such that the resulting structure is a model for phi. We focus our attention on decidability of the synthesis problem for some meaningful fragments of HSeq, whose modalities are drawn from the set A (meets), Abar (met by), B (begins), Bbar (begun by), interpreted over finite linear orders and natural numbers. We prove that the fragment ABBbareq is decidable (non-primitive recursive hard), while the fragment AAbarBBbar turns out to be undecidable. In addition, we show that even the synthesis problem for ABBbar becomes undecidable if we replace finite linear orders by natural numbers.Comment: In Proceedings GandALF 2014, arXiv:1408.556

Coding for Optimized Writing Rate in DNA Storage

A method for encoding information in DNA sequences is described. The method is based on the precisionresolution framework, and is aimed to work in conjunction with a recently suggested terminator-free template independent DNA synthesis method. The suggested method optimizes the amount of information bits per synthesis time unit, namely, the writing rate. Additionally, the encoding scheme studied here takes into account the existence of multiple copies of the DNA sequence, which are independently distorted. Finally, quantizers for various run-length distributions are designed