Autonomous Medical Needle Steering In Vivo

The use of needles to access sites within organs is fundamental to many interventional medical procedures both for diagnosis and treatment. Safe and accurate navigation of a needle through living tissue to an intra-tissue target is currently often challenging or infeasible due to the presence of anatomical obstacles in the tissue, high levels of uncertainty, and natural tissue motion (e.g., due to breathing). Medical robots capable of automating needle-based procedures in vivo have the potential to overcome these challenges and enable an enhanced level of patient care and safety. In this paper, we show the first medical robot that autonomously navigates a needle inside living tissue around anatomical obstacles to an intra-tissue target. Our system leverages an aiming device and a laser-patterned highly flexible steerable needle, a type of needle capable of maneuvering along curvilinear trajectories to avoid obstacles. The autonomous robot accounts for anatomical obstacles and uncertainty in living tissue/needle interaction with replanning and control and accounts for respiratory motion by defining safe insertion time windows during the breathing cycle. We apply the system to lung biopsy, which is critical in the diagnosis of lung cancer, the leading cause of cancer-related death in the United States. We demonstrate successful performance of our system in multiple in vivo porcine studies and also demonstrate that our approach leveraging autonomous needle steering outperforms a standard manual clinical technique for lung nodule access.Comment: 22 pages, 6 figure

The adaptive hermite fractal tree (AHFT): a novel surgical 3D path planning approach with curvature and heading constraints

Purpose In the context of minimally invasive neurosurgery, steerable needles such as the one developed within the Horizon2020-funded EDEN2020 project (Frasson et al. in Proc Inst Mech Eng Part H J Eng Med 224(6):775–88, 2010. https://doi.org/10.1243/09544119JEIM663; Secoli and y Baena in IEEE international conference on robotics and automation, 2013) aspire to address the clinical challenge of better treatment for cancer patients. The direct, precise infusion of drugs in the proximity of a tumor has been shown to enhance its effectiveness and diffusion in the surrounding tissue (Vogelbaum and Aghi in Neuro-Oncology 17(suppl 2):ii3–ii8, 2015. https://doi.org/10.1093/neuonc/nou354). However, planning for an appropriate insertion trajectory for needles such as the one proposed by EDEN2020 is challenging due to factors like kinematic constraints, the presence of complex anatomical structures such as brain vessels, and constraints on the required start and target poses. Methods We propose a new parallelizable three-dimensional (3D) path planning approach called Adaptive Hermite Fractal Tree (AHFT), which is able to generate 3D obstacle-free trajectories that satisfy curvature constraints given a specified start and target pose. The AHFT combines the Adaptive Fractal Tree algorithm’s efficiency (Liu et al. in IEEE Robot Autom Lett 1(2):601–608, 2016. https://doi.org/10.1109/LRA.2016.2528292) with optimized geometric Hermite (Yong and Cheng in Comput Aided Geom Des 21(3):281–301, 2004. https://doi.org/10.1016/j.cagd.2003.08.003) curves, which are able to handle heading constraints. Results Simulated results demonstrate the robustness of the AHFT to perturbations of the target position and target heading. Additionally, a simulated preoperative environment, where the surgeon is able to select a desired entry pose on the patient’s skull, confirms the ability of the method to generate multiple feasible trajectories for a patient-specific case. Conclusions The AHFT method can be adopted in any field of application where a 3D path planner with kinematic and heading constraints on both start and end poses is required

Path planning, modelling and simulation for energy optimised mobile robotics

This thesis is concerned with an investigation of a solution for mobile robotic platforms to minimize the usage of scarce energy that is available and is not wasted following traditionally planned paths for complex terrain environments. This therefore addresses the need to reduce the total energy cost during a field task or mission. A path planning algorithm is designed by creating a new approach of artificial potential field method that generates a planned path, utilising terrain map. The new approach has the capability of avoiding the local minimum problems which is one of the major problems of traditional potential field method. By solving such problems gives a reliable solution to establish a required path. Therefore the approach results in an energy efficient path of the terrain identified, instead obvious straight line of the terrain. A literature review is conducted which reviews the mainstream path planning algorithms with the applications in mobile robotic platforms was analysed. These path planning algorithms are compared for the purpose of energy optimized planning, which concludes the method of artificial potential field as the path planning algorithm which has the most potential and will be further investigated and improved in this research. The methodology of designing, modelling and simulating a mobile robotic platform is defined and presented for the purpose of energy optimized path planning requirement. The research is to clarify the needs, requirements, and specifications of the design. A complete set of models which include mechanical and electrical modelling, functional concept modelling, modelling of the system are established. Based on these models, an energy optimized path planning algorithm is designed. The modelling of force and the kinematics is established to validate and evaluate the result of the algorithm through simulations. Moreover a simulation environment is established which is constructed for multi perspective simulation. This also enables collaborative simulation using Simulink and ADAMS to for simulating a path generated by the path planning algorithm and assess the energy consumption of the driven and steering mechanism of an exemplar system called AgriRover. This simulation environment allows the capture of simulated result of the total energy consumption, therefore outlines the energy cost behaviour of the AgriRover. A total of two sets of paths was tested in the fields for validation, one being generated by the energy optimized path planning algorithm and the other following a straight path. During the field tests the total cost of energy was captured . Two sets of results are compared with each other and compared with the simulation. The comparison shows a 21.34% of the energy saving by deploying the path generated with the energy optimized path planning algorithm in the field test. This research made the following contribution to knowledge. A comparison and grading of mainstream path planning algorithms from energy optimisation perspective is undertaken using detailed evaluation criteria, including computational power required, extendibility, flexibility and more criteria that is relevant for the energy optimized planning purpose. These algorithms have not been compared from energy optimisation angle before, and the research for energy optimised planning under complex terrain environments have not been investigated. Addressing these knowledge gaps, a methodology of designing, modelling and simulating a mobile platform system is proposed to facilitate an energy optimized path planning. This , leads to a new approach of path planning algorithm that reduces unnecessary energy spend for climbing of the terrain, using the terrain data available. Such a methodology derives several novel methods: Namely, a method for avoiding local minimum problem for artificial potential field path planning using the approach of approximation; A method of achieving high expendability of the path planning algorithm, where this method is capable of generate a path through a large map in a short time; A novel method of multi perspective dynamic simulation, which is capable of simulating the behaviour of internal mechanism and the overall robotic mobile platform with the fully integrated control, The dynamic simulation enables prediction of energy consumption; Finally, a novel method of mathematically modelling and simplifying a steering mechanism for the wheel based mobile vehicle was further investigated.This thesis is concerned with an investigation of a solution for mobile robotic platforms to minimize the usage of scarce energy that is available and is not wasted following traditionally planned paths for complex terrain environments. This therefore addresses the need to reduce the total energy cost during a field task or mission. A path planning algorithm is designed by creating a new approach of artificial potential field method that generates a planned path, utilising terrain map. The new approach has the capability of avoiding the local minimum problems which is one of the major problems of traditional potential field method. By solving such problems gives a reliable solution to establish a required path. Therefore the approach results in an energy efficient path of the terrain identified, instead obvious straight line of the terrain. A literature review is conducted which reviews the mainstream path planning algorithms with the applications in mobile robotic platforms was analysed. These path planning algorithms are compared for the purpose of energy optimized planning, which concludes the method of artificial potential field as the path planning algorithm which has the most potential and will be further investigated and improved in this research. The methodology of designing, modelling and simulating a mobile robotic platform is defined and presented for the purpose of energy optimized path planning requirement. The research is to clarify the needs, requirements, and specifications of the design. A complete set of models which include mechanical and electrical modelling, functional concept modelling, modelling of the system are established. Based on these models, an energy optimized path planning algorithm is designed. The modelling of force and the kinematics is established to validate and evaluate the result of the algorithm through simulations. Moreover a simulation environment is established which is constructed for multi perspective simulation. This also enables collaborative simulation using Simulink and ADAMS to for simulating a path generated by the path planning algorithm and assess the energy consumption of the driven and steering mechanism of an exemplar system called AgriRover. This simulation environment allows the capture of simulated result of the total energy consumption, therefore outlines the energy cost behaviour of the AgriRover. A total of two sets of paths was tested in the fields for validation, one being generated by the energy optimized path planning algorithm and the other following a straight path. During the field tests the total cost of energy was captured . Two sets of results are compared with each other and compared with the simulation. The comparison shows a 21.34% of the energy saving by deploying the path generated with the energy optimized path planning algorithm in the field test. This research made the following contribution to knowledge. A comparison and grading of mainstream path planning algorithms from energy optimisation perspective is undertaken using detailed evaluation criteria, including computational power required, extendibility, flexibility and more criteria that is relevant for the energy optimized planning purpose. These algorithms have not been compared from energy optimisation angle before, and the research for energy optimised planning under complex terrain environments have not been investigated. Addressing these knowledge gaps, a methodology of designing, modelling and simulating a mobile platform system is proposed to facilitate an energy optimized path planning. This , leads to a new approach of path planning algorithm that reduces unnecessary energy spend for climbing of the terrain, using the terrain data available. Such a methodology derives several novel methods: Namely, a method for avoiding local minimum problem for artificial potential field path planning using the approach of approximation; A method of achieving high expendability of the path planning algorithm, where this method is capable of generate a path through a large map in a short time; A novel method of multi perspective dynamic simulation, which is capable of simulating the behaviour of internal mechanism and the overall robotic mobile platform with the fully integrated control, The dynamic simulation enables prediction of energy consumption; Finally, a novel method of mathematically modelling and simplifying a steering mechanism for the wheel based mobile vehicle was further investigated

Surgical Subtask Automation for Intraluminal Procedures using Deep Reinforcement Learning

Intraluminal procedures have opened up a new sub-field of minimally invasive surgery that use flexible instruments to navigate through complex luminal structures of the body, resulting in reduced invasiveness and improved patient benefits. One of the major challenges in this field is the accurate and precise control of the instrument inside the human body. Robotics has emerged as a promising solution to this problem. However, to achieve successful robotic intraluminal interventions, the control of the instrument needs to be automated to a large extent. The thesis first examines the state-of-the-art in intraluminal surgical robotics and identifies the key challenges in this field, which include the need for safe and effective tool manipulation, and the ability to adapt to unexpected changes in the luminal environment. To address these challenges, the thesis proposes several levels of autonomy that enable the robotic system to perform individual subtasks autonomously, while still allowing the surgeon to retain overall control of the procedure. The approach facilitates the development of specialized algorithms such as Deep Reinforcement Learning (DRL) for subtasks like navigation and tissue manipulation to produce robust surgical gestures. Additionally, the thesis proposes a safety framework that provides formal guarantees to prevent risky actions. The presented approaches are evaluated through a series of experiments using simulation and robotic platforms. The experiments demonstrate that subtask automation can improve the accuracy and efficiency of tool positioning and tissue manipulation, while also reducing the cognitive load on the surgeon. The results of this research have the potential to improve the reliability and safety of intraluminal surgical interventions, ultimately leading to better outcomes for patients and surgeons