139,988 research outputs found

    Anatomical pathways for auditory memory II: information from rostral superior temporal gyrus to dorsolateral temporal pole and medial temporal cortex

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    Auditory recognition memory in non-human primates differs from recognition memory in other sensory systems. Monkeys learn the rule for visual and tactile delayed matching-to-sample within a few sessions, and then show one-trial recognition memory lasting 10–20 min. In contrast, monkeys require hundreds of sessions to master the rule for auditory recognition, and then show retention lasting no longer than 30–40 s. Moreover, unlike the severe effects of rhinal lesions on visual memory, such lesions have no effect on the monkeys' auditory memory performance. The anatomical pathways for auditory memory may differ from those in vision. Long-term visual recognition memory requires anatomical connections from the visual association area TE with areas 35 and 36 of the perirhinal cortex (PRC). We examined whether there is a similar anatomical route for auditory processing, or that poor auditory recognition memory may reflect the lack of such a pathway. Our hypothesis is that an auditory pathway for recognition memory originates in the higher order processing areas of the rostral superior temporal gyrus (rSTG), and then connects via the dorsolateral temporal pole to access the rhinal cortex of the medial temporal lobe. To test this, we placed retrograde (3% FB and 2% DY) and anterograde (10% BDA 10,000 mW) tracer injections in rSTG and the dorsolateral area 38DL of the temporal pole. Results showed that area 38DL receives dense projections from auditory association areas Ts1, TAa, TPO of the rSTG, from the rostral parabelt and, to a lesser extent, from areas Ts2-3 and PGa. In turn, area 38DL projects densely to area 35 of PRC, entorhinal cortex (EC), and to areas TH/TF of the posterior parahippocampal cortex. Significantly, this projection avoids most of area 36r/c of PRC. This anatomical arrangement may contribute to our understanding of the poor auditory memory of rhesus monkeys

    Multi-Photon Interference and Temporal Distinguishability of Photons

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    A number of recent interference experiments involving multiple photons are reviewed. These experiments include generalized photon bunching effects, generalized Hong-Ou-Mandel interference effects and multi-photon interferometry for demonstrations of multi-photon de Broglie wavelength. The multi-photon states used in these experiments are from two pairs of photons in parametric down-conversion. We find that the size of the interference effect in these experiments, characterized by the visibility of interference pattern, is governed by the degree of distinguishability among different pairs of photons. Based on this discovery, we generalize the concept of multi-photon temporal distinguishability and relate it to a number of multi-photon interference effects. Finally, we make an attempt to interpret the coherence theory by the multi-photon interference via the concept of temporal distinguishability of photons.Comment: fixed figures 4,5,

    Planning and scheduling research at NASA Ames Research Center

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    Planning and scheduling is the area of artificial intelligence research that focuses on the determination of a series of operations to achieve some set of (possibly) interacting goals and the placement of those operations in a timeline that allows them to be accomplished given available resources. Work in this area at the NASA Ames Research Center ranging from basic research in constrain-based reasoning and machine learning, to the development of efficient scheduling tools, to the application of such tools to complex agency problems is described

    Diffuse thalamic projection system in monkey

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    "Sitting too close to the screen can be bad for your ears": A study of audio-visual location discrepancy detection under different visual projections

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    In this work, we look at the perception of event locality under conditions of disparate audio and visual cues. We address an aspect of the so called “ventriloquism effect” relevant for multi-media designers; namely, how auditory perception of event locality is influenced by the size and scale of the accompanying visual projection of those events. We observed that recalibration of the visual axes of an audio-visual animation (by resizing and zooming) exerts a recalibrating influence on the auditory space perception. In particular, sensitivity to audio-visual discrepancies (between a centrally located visual stimuli and laterally displaced audio cue) increases near the edge of the screen on which the visual cue is displayed. In other words,discrepancy detection thresholds are not fixed for a particular pair of stimuli, but are influenced by the size of the display space. Moreover, the discrepancy thresholds are influenced by scale as well as size. That is, the boundary of auditory space perception is not rigidly fixed on the boundaries of the screen; it also depends on the spatial relationship depicted. For example,the ventriloquism effect will break down within the boundaries of a large screen if zooming is used to exaggerate the proximity of the audience to the events. The latter effect appears to be much weaker than the former

    Prenatal Neurogenesis in Autism Spectrum Disorders.

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    An ever-increasing body of literature describes compelling evidence that a subset of young children on the autism spectrum show abnormal cerebral growth trajectories. In these cases, normal cerebral size at birth is followed by a period of abnormal growth and starting in late childhood often by regression compared to unaffected controls. Recent work has demonstrated an abnormal increase in the number of neurons of the prefrontal cortex suggesting that cerebral size increase in autism is driven by excess neuronal production. In addition, some affected children display patches of abnormal laminar positioning of cortical projection neurons. As both cortical projection neuron numbers and their correct layering within the developing cortex requires the undisturbed proliferation of neural progenitors, it appears that neural progenitors lie in the center of the autism pathology associated with early brain overgrowth. Consequently, autism spectrum disorders associated with cerebral enlargement should be viewed as birth defects of an early embryonic origin with profound implications for their early diagnosis, preventive strategies, and therapeutic intervention
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