Practice Makes Imperfect: Restorative Effects of Sleep on Motor Learning

Emerging evidence suggests that sleep plays a key role in procedural learning, particularly in the continued development of motor skill learning following initial acquisition. We argue that a detailed examination of the time course of performance across sleep on the finger-tapping task, established as the paradigm for studying the effect of sleep on motor learning, will help distinguish a restorative role of sleep in motor skill learning from a proactive one. Healthy subjects rehearsed for 12 trials and, following a night of sleep, were tested. Early training rapidly improved speed as well as accuracy on pre-sleep training. Additional rehearsal caused a marked slow-down in further improvement or partial reversal in performance to observed levels below theoretical upper limits derived on the basis of early pre-sleep rehearsal. This decrement in learning efficacy does not occur always, but if and only if it does, overnight sleep has an effect in fully or partly restoring the efficacy and actual performance to the optimal theoretically achieveable level. Our findings re-interpret the sleep-dependent memory enhancement in motor learning reported in the literature as a restoration of fatigued circuitry specialized for the skill. In providing restitution to the fatigued brain, sleep eliminates the rehearsal-induced synaptic fatigue of the circuitry specialized for the task and restores the benefit of early pre-sleep rehearsal. The present findings lend support to the notion that latent sleep-dependent enhancement of performance is a behavioral expression of the brain's restitution in sleep

Effects of Patient-Directed Music Intervention on Anxiety and Sedative Exposure in Critically Ill Patients Receiving Mechanical Ventilatory Support: A Randomized Clinical Trial

Importance: Alternatives to sedative medications, such as music, may alleviate the anxiety associated with ventilatory support. Objective: To test whether listening to self-initiated patient-directed music (PDM) can reduce anxiety and sedative exposure during ventilatory support in critically ill patients. Design, Setting, and Patients: Randomized clinical trial that enrolled 373 patients from 12 intensive care units (ICUs) at 5 hospitals in the Minneapolis-St Paul, Minnesota, area receiving acute mechanical ventilatory support for respiratory failure between September 2006 and March 2011. Of the patients included in the study, 86% were white, 52% were female, and the mean (SD) age was 59 (14) years. The patients had a mean (SD) Acute Physiology, Age and Chronic Health Evaluation III score of 63 (21.6) and a mean (SD) of 5.7 (6.4) study days. Interventions: Self-initiated PDM (n = 126) with preferred selections tailored by a music therapist whenever desired while receiving ventilatory support, self-initiated use of noise-canceling headphones (NCH; n = 122), or usual care (n = 125). Main Outcomes and Measures: Daily assessments of anxiety (on 100-mm visual analog scale) and 2 aggregate measures of sedative exposure (intensity and frequency). Results: Patients in the PDM group listened to music for a mean (SD) of 79.8 (126) (median [range], 12 [0-796]) minutes/day. Patients in the NCH group wore the noise-abating headphones for a mean (SD) of 34.0 (89.6) (median [range], 0 [0-916]) minutes/day. The mixed-models analysis showed that at any time point, patients in the PDM group had an anxiety score that was 19.5 points lower (95% CI, −32.2 to −6.8) than patients in the usual care group (P = .003). By the fifth study day, anxiety was reduced by 36.5% in PDM patients. The treatment × time interaction showed that PDM significantly reduced both measures of sedative exposure. Compared with usual care, the PDM group had reduced sedation intensity by −0.18 (95% CI, −0.36 to −0.004) points/day (P = .05) and had reduced frequency by −0.21 (95% CI, −0.37 to −0.05) points/day (P = .01). The PDM group had reduced sedation frequency by −0.18 (95% CI, −0.36 to −0.004) points/day vs the NCH group (P = .04). By the fifth study day, the PDM patients received 2 fewer sedative doses (reduction of 38%) and had a reduction of 36% in sedation intensity. Conclusions and Relevance: Among ICU patients receiving acute ventilatory support for respiratory failure, PDM resulted in greater reduction in anxiety compared with usual care, but not compared with NCH. Concurrently, PDM resulted in greater reduction in sedation frequency compared with usual care or NCH, and greater reduction in sedation intensity compared with usual care, but not compared with NCH. Trial Registration: clinicaltrials.gov Identifier: NCT00440700 Critically ill mechanically ventilated patients receive intravenous sedative and analgesic medications to reduce anxiety and promote comfort and ventilator synchrony. These potent medications are often administered at high doses for prolonged periods and are associated with adverse effects such as bradycardia, hypotension, gut dysmotility, immobility, weakness, and delirium.1-3 Despite protocols and sedation assessment tools that guide clinicians, patients still experience significant levels of anxiety.4,5 Unrelieved anxiety and fear are not only unpleasant symptoms that clinicians want to palliate, but increased sympathetic nervous system activity can cause dyspnea and increased myocardial oxygen demand.6 Sustained anxiety and sympathetic nervous system activation can decrease the ability to concentrate, rest, or relax.6,7 Mechanically ventilated patients have little control over pharmacological interventions to relieve anxiety; dosing and frequency of sedative and analgesic medications are controlled by intensive care unit (ICU) clinicians. Interventions are needed that reduce anxiety, actively involve patients, and minimize the use of sedative medications. Nonpharmacological interventions such as relaxing music are effective in reducing anxiety while reducing medication administration.8,9 Music is a powerful distractor that can alter perceived levels of anxiety10 by occupying attention channels in the brain with meaningful, auditory stimuli11 rather than stressful environmental stimuli. Listening to preferred, relaxing music has reduced anxiety in mechanically ventilated patients in limited trials.12-15 It is not known if music can reduce anxiety throughout the course of ventilatory support, or reduce exposure to sedative medications. We evaluated if a patient-directed music (PDM) intervention could reduce anxiety and sedative exposure in ICU patients receiving mechanical ventilation

Quantum cryptography with a predetermined key, using continuous variable Einstein-Podolsky-Rosen correlations

Correlations of the type discussed by EPR in their original 1935 paradox for continuous variables exist for the quadrature phase amplitudes of two spatially separated fields. These correlations were experimentally reported in 1992. We propose to use such EPR beams in quantum cryptography, to transmit with high efficiency messages in such a way that the receiver and sender may later determine whether eavesdropping has occurred. The merit of the new proposal is in the possibility of transmitting a reasonably secure yet predetermined key. This would allow relay of a cryptographic key over long distances in the presence of lossy channels.Comment: 11 pages,3 figures, changes are important,presented at QELS(May,2000) San Francisc

SaferCross: Enhancing Pedestrian Safety Using Embedded Sensors of Smartphone

The number of pedestrian accidents continues to keep climbing. Distraction from smartphone is one of the biggest causes for pedestrian fatalities. In this paper, we develop SaferCross, a mobile system based on the embedded sensors of smartphone to improve pedestrian safety by preventing distraction from smartphone. SaferCross adopts a holistic approach by identifying and developing essential system components that are missing in existing systems and integrating the system components into a "fully-functioning" mobile system for pedestrian safety. Specifically, we create algorithms for improving the accuracy and energy efficiency of pedestrian positioning, effectiveness of phone activity detection, and real-time risk assessment. We demonstrate that SaferCross, through systematic integration of the developed algorithms, performs situation awareness effectively and provides a timely warning to the pedestrian based on the information obtained from smartphone sensors and Direct Wi-Fi-based peer-to-peer communication with approaching cars. Extensive experiments are conducted in a department parking lot for both component-level and integrated testing. The results demonstrate that the energy efficiency and positioning accuracy of SaferCross are improved by 52% and 72% on average compared with existing solutions with missing support for positioning accuracy and energy efficiency, and the phone-viewing event detection accuracy is over 90%. The integrated test results show that SaferCross alerts the pedestrian timely with an average error of 1.6sec in comparison with the ground truth data, which can be easily compensated by configuring the system to fire an alert message a couple of seconds early.Comment: Published in IEEE Access, 202

Designing authentication with seniors in mind

Developers typically adopt perceived best practice, and in the case of authentication this means password security. However, given the wide range of technical solutions available and the diverse needs and limitations of older users, we suggest that the default adoption of electronic “username and password” authentication may not be 'best practice' or even good practice. This paper highlights some challenges faced by three seniors, each of whom has multiple age- related disabilities and concomitant life challenges. The result is that they cannot authenticate themselves when they need to access their devices and accounts. We conclude by suggesting a number of research directions calculated to address some of these challenges and promote inclusive design and allow for diverse user authentication

Mobile Network Defense Interface for Cyber Defense and Situational Awareness

Today\u27s computer networks are under constant attack. In order to deal with this constant threat, network administrators rely on intrusion detection and prevention services (IDS) (IPS). Most IDS and IPS implement static rule sets to automatically alert administrators and resolve intrusions. Network administrators face a difficult challenge, identifying attacks against a vast number of benign network transactions. Also after a threat is identified making even the smallest policy change to the security software potentially has far-reaching and unanticipated consequences. Finally, because the administrator is primarily responding to alerts they may lose situational awareness of the network. During this research a MNDI was created that visualized a live network under cyber attack. MNDI allowed test subjects to take actions and make configuration changes in real time on the network. The interface was designed to take advantage of state-of-the-art touch technology engaging the network administrator in the defense of the network. MNDI increased administrator\u27s ability to make time-sensitive decision quickly and accurately on their network. MNDI was tested against a set of open source network administration tool implemented on a desktop system. Both systems used an automated system that polled an ES to resolve zero to 75% of the alerts. The amount of alerts resolved is referred to as level of automation (LOA). During the experiment MNDI outperformed the desktop configuration at all LOAs. The test results showed a statistical difference between the percentage of alerts correctly resolved and the time between actions on MNDI versus desktop test subjects

SAFE: Secure-Roaming Agents for E-commerce

The development of the Internet has made a powerful impact on the concept of commerce. E-commerce, a new way to conduct business, is gaining more and more popularity. Despite its rapid growth, there are limitations that hinder the expansion of e-commerce. The primary concern for most people when talking about on-line shopping is security. Due to the open nature of the Internet, personal financial details necessary for on-line shopping can be stolen if sufficient security mechanism is not put in place. How to provide the necessary assurance of security to consumers remains a question mark despite various past efforts. Another concern is the lack of intelligence. The Internet is an ocean of information depository. It is rich in content but lacks the necessary intelligent tools to help one locate the correct piece of information. Intelligent agent, a piece of software that can act on behalf of its owner intelligently, is designed to fill this gap. However, no matter how intelligent an agent is, if it remains on its owner’s machine and does not have any roaming capability, its functionality is limited. With the roaming capability, more security concerns arise. In response to these concerns, SAFE, Secure roaming Agent For E-commerce, is designed to provide secure roaming capability to intelligent agents

SOFTWARE DEFINED CUSTOMIZATION OF NETWORK PROTOCOLS WITH LAYER 4.5

The rise of software defined networks, programmable data planes, and host level kernel programmability gives rise to highly specialized enterprise networks. One form of network specialization is protocol customization, which traditionally extends existing protocols with additional features, primarily for security and performance reasons. However, the current methodologies to deploy protocol customizations lack the agility to support rapidly changing customization needs. This dissertation designs and evaluates the first software-defined customization architecture capable of distributing and continuously managing protocol customizations within enterprise or datacenter networks. Our unifying architecture is capable of performing per-process customizations, embedding per-network security controls, and aiding the traversal of customized application flows through otherwise problematic middlebox devices. Through the design and evaluation of the customization architecture, we further our understanding of, and provide robust support for, application transparent protocol customizations. We conclude with the first ever demonstration of active application flow "hot-swapping" of protocol customizations, a capability not currently supported in operational networks.Office of Naval Research, Arlington, VA 22203Lieutenant Commander, United States NavyApproved for public release. Distribution is unlimited