Medicaid spending burden among beneficiaries with treatment-resistant depression.

AIM: To evaluate Medicaid spending and healthcare resource utilization (HRU) in treatment-resistant depression (TRD). MATERIALS & METHODS: TRD beneficiaries were identified from Medicaid claims databases (January 2010-March 2017) and matched 1:1 with major depressive disorder (MDD) beneficiaries without TRD (non-TRD-MDD) and randomly selected patients without MDD (non-MDD). Differences in HRU and per-patient-per-year costs were reported in incidence rate ratios (IRRs) and cost differences (CDs), respectively. RESULTS: TRD beneficiaries had higher HRU than 1:1 matched non-TRD-MDD (e.g., inpatient visits: IRR = 1.41) and non-MDD beneficiaries (N = 14,710 per cohort; e.g., inpatient visits: IRR = 3.42, p \u3c 0.01). TRD beneficiaries incurred greater costs versus non-TRD-MDD (CD = US$4382) and non-MDD beneficiaries (CD = US$8294; p \u3c 0.05). CONCLUSION: TRD is associated with higher HRU and costs versus non-TRD-MDD and non-MDD. TRD poses a significant burden to Medicaid

A Monte Carlo code for full simulation of a transition radiation detector

A full simulation of a transition radiation detector (TRD) based on the GEANT, GARFIELD, MAGBOLTZ and HEED codes has been developed. This simulation can be used to study and develop TRD for high energy particle identification using either the cluster counting or the total charge measurement method. In this article it will be also shown an application of this simulation to the discrimination of electrons from hadrons in beams of momentum of few GeV/c or less, assuming typical TRD configuration, namely radiator-detector modules.Comment: 14 pages with 12 figure

Evaluation of a new trauma-related drinking to cope measure: Latent structure and heritability

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur, share latent genetic risk, and are associated with many negative public health outcomes. Via a self-medication framework, trauma-related drinking to cope (TRD), an unexplored phenotype to date, may help explain why these two disorders co-occur, thus serving as an essential target for treatment and prevention efforts. This study sought to create a novel measure of TRD and to investigate its indirect influences on the association between PTSD and AUD, as well as its potential shared molecular genetic risk with PTSD in a genetically-informative study of college students. A sample of 1,896 undergraduate students with a history of trauma and alcohol use provided genotypic data and completed an online assessment battery. The psychometric properties of TRD and how it relates to relevant constructs were examined using descriptive statistics and structural equation modeling. Results of a correlated multiple mediator model indicated that, while accounting for the effects of generalized drinking motives, TRD partially mediated the relation between PTSD and alcohol use problems (β = 0.213, p \u3c .001), consistent with the self-medication hypothesis, and that this relationship was stronger for males (β = 0.804, p \u3c .001) than for females (β = 0.463, p \u3c .001). Results were substantiated using longitudinal data. Genotypic analyses to be presented will include univariate genome wide complex trait analyses (GCTA) to establish SNP-based heritability associated with TRD and PTSD, separately, as well as bivariate GCTA to examine potential overlap in heritability between TRD and PTSD.https://scholarscompass.vcu.edu/gradposters/1047/thumbnail.jp

Development of a trench cutting re-mixing deep wall method model test device

The trench cutting re-mixing deep wall (TRD) is a new type of underground waterproof curtain. Mixing uniformity is the key index affecting the efficiency and quality of this method. However, because of many influencing factors, existing theories cannot be used to express the relationship between various factors and mixing uniformity. By analyzing the cutting and mixing process of the TRD method, the main factors affecting the uniformity of the mixing were obtained. A model test device was designed and manufactured, based on Buckingham's pi theorem. The validity of the model test device was verified through a comparative analysis of model and field test results. The model test device was demonstrated to be able to simulate the mixing process of the TRD method. The results provide guidance for promotion and better application of the TRD method

Some results of test beam studies of Transition Radiation Detector prototypes at CERN

Operating conditions and challenging demands of present and future accelerator experiments result in new requirements on detector systems. There are many ongoing activities aimed to develop new technologies and to improve the properties of detectors based on existing technologies. Our work is dedicated to development of Transition Radiation Detectors (TRD) suitable for different applications. In this paper results obtained in beam tests at SPS accelerator at CERN with the TRD prototype based on straw technology are presented. TRD performance was studied as a function of thickness of the transition radiation radiator and working gas mixture pressure

Particle Identification with the ALICE Transition Radiation Detector

The Transition Radiation Detector (TRD) provides particle identification in the ALICE central barrel. In particular, it allows electron identification via the measurement of transition radiation for $\rm p >$ 1 GeV/$c$, where pions can no longer be rejected sufficiently via specific energy loss in the ALICE Time Projection Chamber. The ALICE TRD is uniquely designed to record the time evolution of the signal, which allows even better electron/pion separation. In addition, the electron identification capability of the TRD can be used on-line to trigger at level 1. The particle identification and its performance in pp, p-Pb and Pb-Pb collisions employing various methods, such as truncated mean signal, one- and two-dimensional likelihood on integrated charge and neural network, will be presented. The measurement of J/$\psi$ mesons in Pb-Pb collisions is given as a case study to show how well the TRD contributes to physics analyses due to its excellent pion suppression.Comment: 4 pages; 7 figures, Proceedings of RICH2013 Conference, 2-6 Dec 201

Physics with the ALICE Transition Radiation Detector

The ALICE Transition Radiation Detector (TRD) significantly enlarges the scope of physics observables studied in ALICE, because it allows due to its electron identification capability to measure open heavy-flavour production and quarkonium states, which are essential probes to characterize the Quark-Gluon-Plasma created in nucleus-nucleus collisions at LHC. In addition the TRD enables to enhance rare probes due to its trigger contributions. We report on the first results of the electron identification capability of the ALICE Transition Radiation Detector (TRD) in pp collisions at $\sqrt{s}$ = 7 TeV using a one-dimensional likelihood method on integrated charge measured in each TRD chamber. The analysis of heavy flavour production in pp collisions at $\sqrt{s}$ = 7 TeV with this particle identification method, which extends the $p_{t}$ range of the existing measurement from $p_{t}$ = 4 GeV/c to 10 GeV/c and reduces the systematic uncertainty due to particle identification, is presented. The performance of the application of the TRD electron identification in the context of J/\psi measurements in Pb-Pb collisions is also shown.Comment: 6 pages; 9 figures; conference proceedings: TRDs for the third Millennium 4th Workshop on Advanced Transition Radiation Detectors for Accelerator and Space Application

Characterization and suppression techniques for degree of radiation damping in inversion recovery measurements

Radiation damping (RD) has been shown to affect T1 measurement in inversion recovery experiments. In this work, we demonstrate that the extent of RD depends upon the T1 of the sample. RD difference spectroscopy (RADDSY) is used to characterize the severity of RD, while gradient inversion recovery (GIR) is used for RD suppression in T1 measurements. At 9.4 T, for the radiation damping characteristic time (Trd) of 50 ms, these investigations show non-negligible RD effects for T1 values greater than Trd, with severe distortions for T1 longer than about 150 ms, showing reasonable agreement with the predicted Trd. We also report a discrepancy between published expressions for the characteristic RD time

The Transition Radiation Detector for ALICE at LHC

The Transition Radiation Detector (TRD) for the ALICE experiment at the Large Hadron Collider (LHC) identifies electrons in p+p and in the challenging high multiplicity environment of heavy-ion collisions and provides fast online tracking for the ALICE Level1 trigger. The TRD is designed to have excellent position resolution and pion rejection capability. Presently, six of the 18 TRD supermodules are installed in the ALICE central barrel. In 2008, four supermodules were installed and commissioning of the detector using cosmic ray tracks was successfully performed. We briefly describe the design of the detector and report on the performance and current understanding of the detector based on these data.Comment: 4 pages, 6 figures - To appear in the conference proceedings for Quark Matter 2009, March 30 - April 4, Knoxville, Tennesse