An integrated approach to global synchronization and state estimation for nonlinear singularly perturbed complex networks

This paper aims to establish a unified framework to handle both the exponential synchronization and state estimation problems for a class of nonlinear singularly perturbed complex networks (SPCNs). Each node in the SPCN comprises both 'slow' and 'fast' dynamics that reflects the singular perturbation behavior. General sector-like nonlinear function is employed to describe the nonlinearities existing in the network. All nodes in the SPCN have the same structures and properties. By utilizing a novel Lyapunov functional and the Kronecker product, it is shown that the addressed SPCN is synchronized if certain matrix inequalities are feasible. The state estimation problem is then studied for the same complex network, where the purpose is to design a state estimator to estimate the network states through available output measurements such that dynamics (both slow and fast) of the estimation error is guaranteed to be globally asymptotically stable. Again, a matrix inequality approach is developed for the state estimation problem. Two numerical examples are presented to verify the effectiveness and merits of the proposed synchronization scheme and state estimation formulation. It is worth mentioning that our main results are still valid even if the slow subsystems within the network are unstable

Network-level dynamics of diffusively coupled cells

We study molecular dynamics within populations of diffusively coupled cells under the assumption of fast diffusive exchange. As a technical tool, we propose conditions on boundedness and ultimate boundedness for systems with a singular perturbation, which extend the classical asymptotic stability results for singularly perturbed systems. Based on these results, we show that with common models of intracellular dynamics, the cell population is coordinated in the sense that all cells converge close to a common equilibrium point. We then study a more specific example of coupled cells which behave as bistable switches, where the intracellular dynamics are such that cells may be in one of two equilibrium points. Here, we find that the whole population is bistable in the sense that it converges to a population state where either all cells are close to the one equilibrium point, or all cells are close to the other equilibrium point. Finally, we discuss applications of these results for the robustness of cellular decision making in coupled populations

On general systems with network-enhanced complexities

In recent years, the study of networked control systems (NCSs) has gradually become an active research area due to the advantages of using networked media in many aspects such as the ease of maintenance and installation, the large flexibility and the low cost. It is well known that the devices in networks are mutually connected via communication cables that are of limited capacity. Therefore, some network-induced phenomena have inevitably emerged in the areas of signal processing and control engineering. These phenomena include, but are not limited to, network-induced communication delays, missing data, signal quantization, saturations, and channel fading. It is of great importance to understand how these phenomena influence the closed-loop stability and performance properties

Collective motion and oscillator synchronization

This paper studies connections between phase models of coupled oscillators and kinematic models of groups of self-propelled particles. These connections are exploited in the analysis and design of feedback control laws for the individuals that stabilize collective motions for the group

Shaping bursting by electrical coupling and noise

Gap-junctional coupling is an important way of communication between neurons and other excitable cells. Strong electrical coupling synchronizes activity across cell ensembles. Surprisingly, in the presence of noise synchronous oscillations generated by an electrically coupled network may differ qualitatively from the oscillations produced by uncoupled individual cells forming the network. A prominent example of such behavior is the synchronized bursting in islets of Langerhans formed by pancreatic \beta-cells, which in isolation are known to exhibit irregular spiking. At the heart of this intriguing phenomenon lies denoising, a remarkable ability of electrical coupling to diminish the effects of noise acting on individual cells. In this paper, we derive quantitative estimates characterizing denoising in electrically coupled networks of conductance-based models of square wave bursting cells. Our analysis reveals the interplay of the intrinsic properties of the individual cells and network topology and their respective contributions to this important effect. In particular, we show that networks on graphs with large algebraic connectivity or small total effective resistance are better equipped for implementing denoising. As a by-product of the analysis of denoising, we analytically estimate the rate with which trajectories converge to the synchronization subspace and the stability of the latter to random perturbations. These estimates reveal the role of the network topology in synchronization. The analysis is complemented by numerical simulations of electrically coupled conductance-based networks. Taken together, these results explain the mechanisms underlying synchronization and denoising in an important class of biological models

Landscapes of Non-gradient Dynamics Without Detailed Balance: Stable Limit Cycles and Multiple Attractors

Landscape is one of the key notions in literature on biological processes and physics of complex systems with both deterministic and stochastic dynamics. The large deviation theory (LDT) provides a possible mathematical basis for the scientists' intuition. In terms of Freidlin-Wentzell's LDT, we discuss explicitly two issues in singularly perturbed stationary diffusion processes arisen from nonlinear differential equations: (1) For a process whose corresponding ordinary differential equation has a stable limit cycle, the stationary solution exhibits a clear separation of time scales: an exponential terms and an algebraic prefactor. The large deviation rate function attains its minimum zero on the entire stable limit cycle, while the leading term of the prefactor is inversely proportional to the velocity of the non-uniform periodic oscillation on the cycle. (2) For dynamics with multiple stable fixed points and saddles, there is in general a breakdown of detailed balance among the corresponding attractors. Two landscapes, a local and a global, arise in LDT, and a Markov jumping process with cycle flux emerges in the low-noise limit. A local landscape is pertinent to the transition rates between neighboring stable fixed points; and the global landscape defines a nonequilibrium steady state. There would be nondifferentiable points in the latter for a stationary dynamics with cycle flux. LDT serving as the mathematical foundation for emergent landscapes deserves further investigations.Comment: 4 figur