Middleware Technologies for Cloud of Things - a survey

The next wave of communication and applications rely on the new services provided by Internet of Things which is becoming an important aspect in human and machines future. The IoT services are a key solution for providing smart environments in homes, buildings and cities. In the era of a massive number of connected things and objects with a high grow rate, several challenges have been raised such as management, aggregation and storage for big produced data. In order to tackle some of these issues, cloud computing emerged to IoT as Cloud of Things (CoT) which provides virtually unlimited cloud services to enhance the large scale IoT platforms. There are several factors to be considered in design and implementation of a CoT platform. One of the most important and challenging problems is the heterogeneity of different objects. This problem can be addressed by deploying suitable "Middleware". Middleware sits between things and applications that make a reliable platform for communication among things with different interfaces, operating systems, and architectures. The main aim of this paper is to study the middleware technologies for CoT. Toward this end, we first present the main features and characteristics of middlewares. Next we study different architecture styles and service domains. Then we presents several middlewares that are suitable for CoT based platforms and lastly a list of current challenges and issues in design of CoT based middlewares is discussed.Comment: http://www.sciencedirect.com/science/article/pii/S2352864817301268, Digital Communications and Networks, Elsevier (2017

Middleware Technologies for Cloud of Things - a survey

The next wave of communication and applications rely on the new services provided by Internet of Things which is becoming an important aspect in human and machines future. The IoT services are a key solution for providing smart environments in homes, buildings and cities. In the era of a massive number of connected things and objects with a high grow rate, several challenges have been raised such as management, aggregation and storage for big produced data. In order to tackle some of these issues, cloud computing emerged to IoT as Cloud of Things (CoT) which provides virtually unlimited cloud services to enhance the large scale IoT platforms. There are several factors to be considered in design and implementation of a CoT platform. One of the most important and challenging problems is the heterogeneity of different objects. This problem can be addressed by deploying suitable "Middleware". Middleware sits between things and applications that make a reliable platform for communication among things with different interfaces, operating systems, and architectures. The main aim of this paper is to study the middleware technologies for CoT. Toward this end, we first present the main features and characteristics of middlewares. Next we study different architecture styles and service domains. Then we presents several middlewares that are suitable for CoT based platforms and lastly a list of current challenges and issues in design of CoT based middlewares is discussed.Comment: http://www.sciencedirect.com/science/article/pii/S2352864817301268, Digital Communications and Networks, Elsevier (2017

Dynamic trust negotiation for decentralised e-health collaborations

In the Internet-age, the geographical boundaries that have previously impinged upon inter-organisational collaborations have become decreasingly important. Of more importance for such collaborations is the notion and subsequent nature of security and trust - this is especially so in open collaborative environments like the Grid where resources can be both made available, subsequently accessed and used by remote users from a multitude of institutions with a variety of different privileges spanning across the collaboration. In this context, the ability to dynamically negotiate and subsequently enforce security policies driven by various levels of inter-organisational trust is essential. Numerous access control solutions exist today to address aspects of inter-organisational security. These include the use of centralised access control lists where all collaborating partners negotiate and agree on privileges required to access shared resources. Other solutions involve delegating aspects of access right management to trusted remote individuals in assigning privileges to their (remote) users. These solutions typically entail negotiations and delegations which are constrained by organisations, people and the static rules they impose. Such constraints often result in a lack of flexibility in what has been agreed; difficulties in reaching agreement, or once established, in subsequently maintaining these agreements. Furthermore, these solutions often reduce the autonomous capacity of collaborating organisations because of the need to satisfy collaborating partners demands. This can result in increased security risks or reducing the granularity of security policies. Underpinning this is the issue of trust. Specifically trust realisation between organisations, between individuals, and/or between entities or systems that are present in multi-domain authorities. Trust negotiation is one approach that allows and supports trust realisation. The thesis introduces a novel model called dynamic trust negotiation (DTN) that supports n-tier negotiation hops for trust realisation in multi-domain collaborative environments with specific focus on e-Health environments. DTN describes how trust pathways can be discovered and subsequently how remote security credentials can be mapped to local security credentials through trust contracts, thereby bridging the gap that makes decentralised security policies difficult to define and enforce. Furthermore, DTN shows how n-tier negotiation hops can limit the disclosure of access control policies and how semantic issues that exist with security attributes in decentralised environments can be reduced. The thesis presents the results from the application of DTN to various clinical trials and the implementation of DTN to Virtual Organisation for Trials of Epidemiological Studies (VOTES). The thesis concludes that DTN can address the issue of realising and establishing trust between systems or agents within the e-Health domain, such as the clinical trials domain

The development of modern Chinese banking

Thesis (M.A.)--Boston UniversityThis study purports to evaluate the relationship between the Chinese modern banking system and the activities or the national economy and to describe the significance of its development on China's peace and war economy. The problem is to be approached by tracing the formation of banking institutions and developments, by investigating the internal organization and practices and by analyzing the influence of Government financial policies. It covers the period from the appearance of the first Chinese-owned modern bank in 1897 to the New Monetary Reform in 1948. The meagerness of data necessarily renders this study far from being complete; the most significant characteristics of the development, however, are to be considered

Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine

Glutamate receptors sensitive to N-methyl-d-aspartate (NMDA) are involved in embryonic brain development but their activity may be modulated by the kynurenine pathway of tryptophan metabolism which includes an agonist (quinolinic acid) and an antagonist (kynurenic acid) at these receptors. Our previous work has shown that prenatal inhibition of the pathway produces abnormalities of brain development. In the present study kynurenine and probenecid (both 100 mg/kg, doses known to increase kynurenic acid levels in the brain) were administered to female Wistar rats on embryonic days E14, E16 and E18 of gestation and the litter was allowed to develop to post-natal day P60. Western blotting revealed no changes in hippocampal expression of several proteins previously found to be altered by inhibition of the kynurenine pathway including the NMDA receptor subunits GluN1, GluN2A and GluN2B, as well as doublecortin, Proliferating Cell Nuclear Antigen (PCNA), sonic hedgehog and unco-ordinated (unc)-5H1 and 5H3. Mice lacking the enzyme kynurenine-3-monoxygenase (KMO) also showed no changes in hippocampal expression of several of these proteins or the 70-kDa and 100-kDa variants of Disrupted in Schizophrenia-1 (DISC1). Electrical excitability of pyramidal neurons in the CA1 region of hippocampal slices was unchanged, as was paired-pulse facilitation and inhibition. Long-term potentiation was decreased in the kynurenine-treated rats and in the KMO(−/−) mice, but galantamine reversed this effect in the presence of nicotinic receptor antagonists, consistent with evidence that it can potentiate glutamate at NMDA receptors. It is concluded that interference with the kynurenine pathway in utero can have lasting effects on brain function of the offspring, implying that the kynurenine pathway is involved in the regulation of early brain development

Recent advances in low oxidation state aluminium chemistry

Documenting the synthesis and isolation of novel low oxidation state aluminium (Al) compounds, which until recently has seen relatively slow progress over the 30 years since such species were first isolated

Core cis-element variation confers subgenome-biased expression of a transcription factor that functions in cotton fiber elongation

Cotton cultivars have evolved to produce extensive, long, seed-born fibers important for the textile industry, but we know little about the molecular mechanism underlying spinnable fiber formation. Here, we report how PACLOBUTRAZOL RESISTANCE 1 (PRE1) in cotton, which encodes a basic helix-loop-helix (bHLH) transcription factor, is a target gene of spinnable fiber evolution. Differential expression of homoeologous genes in polyploids is thought to be important to plant adaptation and novel phenotypes. PRE1 expression is specific to cotton fiber cells, upregulated during their rapid elongation stage and A-homoeologous biased in allotetraploid cultivars. Transgenic studies demonstrated that PRE1 is a positive regulator of fiber elongation. We determined that the natural variation of the canonical TATA-box, a regulatory element commonly found in many eukaryotic core promoters, is necessary for subgenome-biased PRE1 expression, representing a mechanism underlying the selection of homoeologous genes. Thus, variations in the promoter of the cell elongation regulator gene PRE1 have contributed to spinnable fiber formation in cotton. Overexpression of GhPRE1 in transgenic cotton yields longer fibers with improved quality parameters, indicating that this bHLH gene is useful for improving cotton fiber quality