19,974 research outputs found
Spatiotemporal adaptation through corticothalamic loops: A hypothesis
The thalamus is the major gate to the cortex and its control over cortical responses is well established. Cortical feedback to the thalamus is, in turn, the anatomically dominant input to relay cells, yet its influence on thalamic processing has been difficult to interpret. For an understanding of complex sensory processing, detailed concepts of the corticothalamic interplay need yet to be established. Drawing on various physiological and anatomical data, we elaborate the novel hypothesis that the visual cortex controls the spatiotemporal structure of cortical receptive fields via feedback to the lateral geniculate nucleus. Furthermore, we present and analyze a model of corticogeniculate loops that implements this control, and exhibit its ability of object segmentation by statistical motion analysis in the visual field
A statistical method for revealing form-function relations in biological networks
Over the past decade, a number of researchers in systems biology have sought
to relate the function of biological systems to their network-level
descriptions -- lists of the most important players and the pairwise
interactions between them. Both for large networks (in which statistical
analysis is often framed in terms of the abundance of repeated small subgraphs)
and for small networks which can be analyzed in greater detail (or even
synthesized in vivo and subjected to experiment), revealing the relationship
between the topology of small subgraphs and their biological function has been
a central goal. We here seek to pose this revelation as a statistical task,
illustrated using a particular setup which has been constructed experimentally
and for which parameterized models of transcriptional regulation have been
studied extensively. The question "how does function follow form" is here
mathematized by identifying which topological attributes correlate with the
diverse possible information-processing tasks which a transcriptional
regulatory network can realize. The resulting method reveals one form-function
relationship which had earlier been predicted based on analytic results, and
reveals a second for which we can provide an analytic interpretation. Resulting
source code is distributed via http://formfunction.sourceforge.net.Comment: To appear in Proc. Natl. Acad. Sci. USA. 17 pages, 9 figures, 2
table
Inhibitory neurons exhibit high controlling ability in the cortical microconnectome
脳が安定して活動を続けられるメカニズムの一端を解明 --新皮質で、抑制性細胞は他細胞を制御しやすいトポロジカルな位置取りをする--. 京都大学プレスリリース. 2021-04-09.The brain is a network system in which excitatory and inhibitory neurons keep activity balanced in the highly non-random connectivity pattern of the microconnectome. It is well known that the relative percentage of inhibitory neurons is much smaller than excitatory neurons in the cortex. So, in general, how inhibitory neurons can keep the balance with the surrounding excitatory neurons is an important question. There is much accumulated knowledge about this fundamental question. This study quantitatively evaluated the relatively higher functional contribution of inhibitory neurons in terms of not only properties of individual neurons, such as firing rate, but also in terms of topological mechanisms and controlling ability on other excitatory neurons. We combined simultaneous electrical recording (~2.5 hours) of ~1000 neurons in vitro, and quantitative evaluation of neuronal interactions including excitatory-inhibitory categorization. This study accurately defined recording brain anatomical targets, such as brain regions and cortical layers, by inter-referring MRI and immunostaining recordings. The interaction networks enabled us to quantify topological influence of individual neurons, in terms of controlling ability to other neurons. Especially, the result indicated that highly influential inhibitory neurons show higher controlling ability of other neurons than excitatory neurons, and are relatively often distributed in deeper layers of the cortex. Furthermore, the neurons having high controlling ability are more effectively limited in number than central nodes of k-cores, and these neurons also participate in more clustered motifs. In summary, this study suggested that the high controlling ability of inhibitory neurons is a key mechanism to keep balance with a large number of other excitatory neurons beyond simple higher firing rate. Application of the selection method of limited important neurons would be also applicable for the ability to effectively and selectively stimulate E/I imbalanced disease states
Attention-deficit/hyperactivity disorder: a closer look
Includes bibliographical references
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