Mulsemedia: State of the art, perspectives, and challenges

Mulsemedia-multiple sensorial media-captures a wide variety of research efforts and applications. This article presents a historic perspective on mulsemedia work and reviews current developments in the area. These take place across the traditional multimedia spectrum-from virtual reality applications to computer games-as well as efforts in the arts, gastronomy, and therapy, to mention a few. We also describe standardization efforts, via the MPEG-V standard, and identify future developments and exciting challenges the community needs to overcome

Bioinformatics Databases: State of the Art and Research Perspectives

Bioinformatics or computational biology, i.e. the application of mathematical and computer science methods to solving problems in molecular biology that require large scale data, computation, and analysis, is a research area currently receiving a considerable attention. Databases play an essential role in molecular biology and consequently in bioinformatics. molecular biology data are often relatively cheap to produce, leading to a proliferation of databases: the number of bioinformatics databases accessible worldwide probably lies between 500 and 1.000. Not only molecular biology data, but also molecular biology literature and literature references are stored in databases. Bioinformatics databases are often very large (e.g. the sequence database GenBank contains more than 4 × 10 6 nucleotide sequences) and in general grows rapidly (e.g. about 8000 abstracts are added every month to the literature database PubMed). Bioinformatics databases are heterogeneous in their data, in their data modeling paradigms, in their management systems, and in the data analysis tools they supports. Furthermore, bioinformatics databases are often implemented, queried, updated, and managed using methods rarely applied for other databases. This presentation aims at introducing in current bioinformatics databases, stressing their aspects departing from conventional databases. A more detailed survey can be found in [1] upon which thi

Rapid manufacturing- state of the art, analysis and future perspectives

Layer based manufacturing system often referred to as Rapid Prototyping (RP) have been in existence for 22 years, in the past 5 years Rapid Manufacturing (RM) has emerged from these RP systems to produce functional and structural customer focused end use components and products. This keynote paper will review the current range of technologies for metallic systems, it will also evaluate the operating principles, features, potential and limitations of current commercially available systems. Rapid Manufacture is increasingly being used for high value difficult to manufacture components with a new set of design rules required to fully exploit the RM systems inherent characteristics. A case studies approach will be used to show the benefits and pitfalls this new design freedom can provide designers

Planar Ising model at criticality: state-of-the-art and perspectives

In this essay, we briefly discuss recent developments, started a decade ago in the seminal work of Smirnov and continued by a number of authors, centered around the conformal invariance of the critical planar Ising model on $\mathbb{Z}^2$ and, more generally, of the critical Z-invariant Ising model on isoradial graphs (rhombic lattices). We also introduce a new class of embeddings of general weighted planar graphs (s-embeddings), which might, in particular, pave the way to true universality results for the planar Ising model.Comment: 19 pages (+ references), prepared for the Proceedings of ICM2018. Second version: two references added, a few misprints fixe

Biomethane technology for grid injection

This is a poster that describes the state-of-the art and perspectives for biomethane as technology for grid injectio

Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives

While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant. Gene transfer offers the prospect of highly specific therapies for childhood cancer. “Corrective” genes may be transferred to overcome the genetic abnormalities present in the precancerous cell. Alternatively, genes can be introduced to render the malignant cell sensitive to therapeutic drugs. The tumor can also be attacked by decreasing its blood supply with genes that inhibit vascular growth. Another possible approach is to modify normal tissues with genes that make them more resistant to conventional drugs and/or radiation, thereby increasing the therapeutic index. Finally, it may be possible to attack the tumor indirectly by using genes that modify the behavior of the immune system, either by making the tumor more immunogenic, or by rendering host effector cells more efficient. Several gene therapy applications have already been reported for pediatric cancer patients in preliminary Phase 1 studies. Although no major clinical success has yet been achieved, improvements in gene delivery technologies and a better understanding of mechanisms of tumor progression and immune escape have opened new perspectives for the cure of pediatric cancer by combining gene therapy with standard therapeutic available treatments

The Gamma-ray Blazar Quest: new optical spectra, state of art and future perspectives

We recently developed a procedure to recognize gamma-ray blazar candidates within the positional uncertainty regions of the unidentified/unassociated gamma-ray sources (UGSs). Such procedure was based on the discovery that Fermi blazars show peculiar infrared colors. However, to confirm the real nature of the selected candidates, optical spectroscopic data are necessary. Thus, we performed an extensive archival search for spectra available in the literature in parallel with an optical spectroscopic campaign aimed to reveal and confirm the nature of the selected gamma-ray blazar candidates. Here, we first search for optical spectra of a selected sample of gamma-ray blazar candidates that can be potential counterparts of UGSs using the Sloan Digital Sky Survey (SDSS DR12). This search enables us to update the archival search carried out to date. We also describe the state-of-art and the future perspectives of our campaign to discover previously unknown gamma-ray blazars.Comment: 11 pages, 2 figures, 5 tables, pre-proof version, accepted for publication of Astrophysics and Space Scienc