Synchronization in output-coupled temporal Boolean networks

This paper presents an analytical study of synchronization in an array of output-coupled temporal Boolean networks. A temporal Boolean network (TBN) is a logical dynamic system developed to model Boolean networks with regulatory delays. Both state delay and output delay are considered, and these two delays are assumed to be different. By referring to the algebraic representations of logical dynamics and using the semi-tensor product of matrices, the output-coupled TBNs are firstly converted into a discrete-time algebraic evolution system, and then the relationship between the states of coupled TBNs and the initial state sequence is obtained. Then, some necessary and sufficient conditions are derived for the synchronization of an array of TBNs with an arbitrary given initial state sequence. Two numerical examples including one epigenetic model are finally given to illustrate the obtained results

IEEE Access Special Section Editorial: Recent Advances on Hybrid Complex Networks: Analysis and Control

Complex networks typically involve multiple disciplines due to network dynamics and their statistical nature. When modeling practical networks, both impulsive effects and logical dynamics have recently attracted increasing attention. Hence, it is of interest and importance to consider hybrid complex networks with impulsive effects and logical dynamics. Relevant research is prevalent in cells, ecology, social systems, and communication engineering. In hybrid complex networks, numerous nodes are coupled through networks and their properties usually lead to complex dynamic behaviors, including discrete and continuous dynamics with finite values of time and state space. Generally, continuous and discrete sections of the systems are described by differential and difference equations, respectively. Logical networks are used to model the systems where time and state space take finite values. Although interesting results have been reported regarding hybrid complex networks, the analysis methods and relevant results could be further improved with respect to conservative impulsive delay inequalities and reproducibility of corresponding stability or synchronization criteria. Therefore, it is necessary to devise effective approaches to improve the analysis method and results dealing with hybrid complex networks

Pinning controllability of autonomous Boolean control networks

Autonomous Boolean networks (ABNs), which are developed to model the Boolean networks (BNs) with regulatory delays, are well known for their advantages of characterizing the intrinsic evolution rules of biological systems such as the gene regulatory networks. As a special type of ABNs with binary inputs, the autonomous Boolean control networks (ABCNs) are introduced for designing and analyzing the therapeutic intervention strategies where the binary inputs represent whether a certain medicine is dominated or not. An important problem in the therapeutic intervention is to design a control sequence steering an ABCN from an undesirable location (implying a diseased state) to a desirable one (corresponding to a healthy state). Motivated by such background, this paper aims to investigate the reachability and controllability of ABCNs with pinning controllers. Several necessary and sufficient criteria are provided by resorting to the semi-tensor product techniques of matrices. Moreover, an effective pinning control algorithm is presented for steering an ABCN from any given states to the desired state in the shortest time period. Numerical examples are also presented to demonstrate the results obtained.This work was supported in part by National Natural Science Foundation of China (Grant Nos. 61329301, 61273156), Natural Science Foundation of Jiangsu Province of China (Grant No. BK20130017), Six Talent Peaks Project for the High Level Personnel from the Jiangsu Province of China (Grant No. 2015- DZXX-003), Scientific Research Foundations of Graduate School of Southeast University (Grant No. YBJJ1560), and Innovation Program of Jiangsu Province (Grant No. KYZZ15 0050)

Data based identification and prediction of nonlinear and complex dynamical systems

We thank Dr. R. Yang (formerly at ASU), Dr. R.-Q. Su (formerly at ASU), and Mr. Zhesi Shen for their contributions to a number of original papers on which this Review is partly based. This work was supported by ARO under Grant No. W911NF-14-1-0504. W.-X. Wang was also supported by NSFC under Grants No. 61573064 and No. 61074116, as well as by the Fundamental Research Funds for the Central Universities, Beijing Nova Programme.Peer reviewedPostprin

DEGRADACIÓN ANORMAL DE P53 E INDUCCIÓN DE APOPTOSIS EN LA RED P53-MDM2 USANDO LA ESTRATEGIA DE CONTROL TIPO PIN

Este artículo presenta el control tipo “PIN” para regular la actividad de la red p53-Mdm2. Esta red considera la degradación de p53 mediada por el incremento de Mdm2, el cual perturba la respuesta de estrés normal de p53. El modelo considera tres proteínas: p53, Mdm2 y ARF. p53 es regulado a través de un ciclo de retroalimentación que involucra su gen objetivo Mdm2 y un regulador indirecto ARF. Se presentan dos escenarios. Para el primer escenario, la red responde a un incremento de Mdm2 y una baja regulación de p53 sin ninguna entrada externa; luego, en el segundo escenario apoptosis es inducido por el control tipo “PIN”. El comportamiento dinámico de la red y la efectividad del controlador propuesto son ilustrados vía simulaciones