1,389 research outputs found
MuCIGREF: multiple computer-interpretable guideline representation and execution framework for managing multimobidity care
Clinical Practice Guidelines (CPGs) supply evidence-based recommendations to healthcare professionals (HCPs) for the care of patients. Their use in clinical practice has many benefits for patients, HCPs and treating medical centres, such as enhancing the quality of care, and reducing unwanted care variations. However, there are many challenges limiting their implementations. Initially, CPGs predominantly consider a specific disease, and only few of them refer to multimorbidity (i.e. the presence of two or more health conditions in an individual) and they are not able to adapt to dynamic changes in patient health conditions. The manual management of guideline recommendations are also challenging since recommendations may adversely interact with each other due to their competing targets and/or they can be duplicated when multiple of them are concurrently applied to a multimorbid patient. These may result in undesired outcomes such as severe disability, increased hospitalisation costs and many others. Formalisation of CPGs into a Computer Interpretable Guideline (CIG) format, allows the guidelines to be interpreted and processed by computer applications, such as Clinical Decision Support Systems (CDSS). This enables provision of automated support to manage the limitations of guidelines.
This thesis introduces a new approach for the problem of combining multiple concurrently implemented CIGs and their interrelations to manage multimorbidity care. MuCIGREF (Multiple Computer-Interpretable Guideline Representation and Execution Framework), is proposed whose specific objectives are to present (1) a novel multiple CIG representation language, MuCRL, where a generic ontology is developed to represent knowledge elements of CPGs and their interrelations, and to create the multimorbidity related associations between them. A systematic literature review is conducted to discover CPG representation requirements and gaps in multimorbidity care management. The ontology is built based on the synthesis of well-known ontology building lifecycle methodologies. Afterwards, the ontology is transformed to a metamodel to support the CIG execution phase; and (2) a novel real-time multiple CIG execution engine, MuCEE, where CIG models are dynamically combined to generate consistent and personalised care plans for multimorbid patients. MuCEE involves three modules as (i) CIG acquisition module, transfers CIGs to the personal care plan based on the patient’s health conditions and to supply CIG version control; (ii) parallel CIG execution module, combines concurrently implemented multiple CIGs by performing concurrency management, time-based synchronisation (e.g., multi-activity merging), modification, and timebased optimisation of clinical activities; and (iii) CIG verification module, checks missing information, and inconsistencies to support CIG execution phases. Rulebased execution algorithms are presented for each module. Afterwards, a set of verification and validation analyses are performed involving real-world multimorbidity cases studies and comparative analyses with existing works. The results show that the proposed framework can combine multiple CIGs and dynamically merge, optimise and modify multiple clinical activities of them involving patient data.
This framework can be used to support HCPs in a CDSS setting to generate unified and personalised care recommendations for multimorbid patients while merging multiple guideline actions and eliminating care duplications to maintain their safety and supplying optimised health resource management, which may improve operational and cost efficiency in real world-cases, as well
A standards-based ICT framework to enable a service-oriented approach to clinical decision support
This research provides evidence that standards based Clinical Decision Support (CDS)
at the point of care is an essential ingredient of electronic healthcare service delivery. A
Service Oriented Architecture (SOA) based solution is explored, that serves as a task
management system to coordinate complex distributed and disparate IT systems,
processes and resources (human and computer) to provide standards based CDS.
This research offers a solution to the challenges in implementing computerised CDS such
as integration with heterogeneous legacy systems. Reuse of components and services to
reduce costs and save time. The benefits of a sharable CDS service that can be reused by
different healthcare practitioners to provide collaborative patient care is demonstrated.
This solution provides orchestration among different services by extracting data from
sources like patient databases, clinical knowledge bases and evidence-based clinical
guidelines (CGs) in order to facilitate multiple CDS requests coming from different
healthcare settings. This architecture aims to aid users at different levels of Healthcare
Delivery Organizations (HCOs) to maintain a CDS repository, along with monitoring and
managing services, thus enabling transparency.
The research employs the Design Science research methodology (DSRM) combined with
The Open Group Architecture Framework (TOGAF), an open source group initiative for
Enterprise Architecture Framework (EAF). DSRM’s iterative capability addresses the
rapidly evolving nature of workflows in healthcare. This SOA based solution uses
standards-based open source technologies and platforms, the latest healthcare standards
by HL7 and OMG, Decision Support Service (DSS) and Retrieve, Update Locate Service
(RLUS) standard. Combining business process management (BPM) technologies,
business rules with SOA ensures the HCO’s capability to manage its processes. This
architectural solution is evaluated by successfully implementing evidence based CGs at
the point of care in areas such as; a) Diagnostics (Chronic Obstructive Disease), b) Urgent
Referral (Lung Cancer), c) Genome testing and integration with CDS in screening
(Lynch’s syndrome). In addition to medical care, the CDS solution can benefit
organizational processes for collaborative care delivery by connecting patients,
physicians and other associated members. This framework facilitates integration of
different types of CDS ideal for the different healthcare processes, enabling sharable CDS
capabilities within and across organizations
Implementation of workflow engine technology to deliver basic clinical decision support functionality
BACKGROUND: Workflow engine technology represents a new class of software with the ability to graphically model step-based knowledge. We present application of this novel technology to the domain of clinical decision support. Successful implementation of decision support within an electronic health record (EHR) remains an unsolved research challenge. Previous research efforts were mostly based on healthcare-specific representation standards and execution engines and did not reach wide adoption. We focus on two challenges in decision support systems: the ability to test decision logic on retrospective data prior prospective deployment and the challenge of user-friendly representation of clinical logic. RESULTS: We present our implementation of a workflow engine technology that addresses the two above-described challenges in delivering clinical decision support. Our system is based on a cross-industry standard of XML (extensible markup language) process definition language (XPDL). The core components of the system are a workflow editor for modeling clinical scenarios and a workflow engine for execution of those scenarios. We demonstrate, with an open-source and publicly available workflow suite, that clinical decision support logic can be executed on retrospective data. The same flowchart-based representation can also function in a prospective mode where the system can be integrated with an EHR system and respond to real-time clinical events. We limit the scope of our implementation to decision support content generation (which can be EHR system vendor independent). We do not focus on supporting complex decision support content delivery mechanisms due to lack of standardization of EHR systems in this area. We present results of our evaluation of the flowchart-based graphical notation as well as architectural evaluation of our implementation using an established evaluation framework for clinical decision support architecture. CONCLUSIONS: We describe an implementation of a free workflow technology software suite (available at http://code.google.com/p/healthflow) and its application in the domain of clinical decision support. Our implementation seamlessly supports clinical logic testing on retrospective data and offers a user-friendly knowledge representation paradigm. With the presented software implementation, we demonstrate that workflow engine technology can provide a decision support platform which evaluates well against an established clinical decision support architecture evaluation framework. Due to cross-industry usage of workflow engine technology, we can expect significant future functionality enhancements that will further improve the technology's capacity to serve as a clinical decision support platform
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Computerization of workflows, guidelines and care pathways: a review of implementation challenges for process-oriented health information systems
There is a need to integrate the various theoretical frameworks and formalisms for modeling clinical guidelines, workflows, and pathways, in order to move beyond providing support for individual clinical decisions and toward the provision of process-oriented, patient-centered, health information systems (HIS). In this review, we analyze the challenges in developing process-oriented HIS that formally model guidelines, workflows, and care pathways. A qualitative meta-synthesis was performed on studies published in English between 1995 and 2010 that addressed the modeling process and reported the exposition of a new methodology, model, system implementation, or system architecture. Thematic analysis, principal component analysis (PCA) and data visualisation techniques were used to identify and cluster the underlying implementation ‘challenge’ themes. One hundred and eight relevant studies were selected for review. Twenty-five underlying ‘challenge’ themes were identified. These were clustered into 10 distinct groups, from which a conceptual model of the implementation process was developed. We found that the development of systems supporting individual clinical decisions is evolving toward the implementation of adaptable care pathways on the semantic web, incorporating formal, clinical, and organizational ontologies, and the use of workflow management systems. These architectures now need to be implemented and evaluated on a wider scale within clinical settings
Medical Big Data Analysis in Hospital Information System
The rapidly increasing medical data generated from hospital information system (HIS) signifies the era of Big Data in the healthcare domain. These data hold great value to the workflow management, patient care and treatment, scientific research, and education in the healthcare industry. However, the complex, distributed, and highly interdisciplinary nature of medical data has underscored the limitations of traditional data analysis capabilities of data accessing, storage, processing, analyzing, distributing, and sharing. New and efficient technologies are becoming necessary to obtain the wealth of information and knowledge underlying medical Big Data. This chapter discusses medical Big Data analysis in HIS, including an introduction to the fundamental concepts, related platforms and technologies of medical Big Data processing, and advanced Big Data processing technologies
A comprehensive clinical guideline model and a reasoning mechanism for AAL systems
The progressive ageing of population combined with the need for comfort in situations of disease and disability are pushing healthcare organizations and governments to find new solutions to enable people to live longer in their preferred environment, while having access to quality healthcare services. iGenda is an Ambient Assisted Living platform that provides constant monitoring to people with this type of needs. The use of a Computer-Interpretable Guideline model for decision making is one of the features of this platform. The model used to represent Clinical Practice Guidelines gathers a set of features that make guidelines more dynamic and easily implementable. The model is defined using Ontology Web Language, profiting from the existing constructors provided by this language. It is based on a set of primitive tasks, namely Plans, Actions, Questions and Decisions. Focusing on decision support, a method for dealing with incomplete information about the clinical parameters of a health record is presented. The objective is to keep a continuous flow of information through the decision process and assuring that an outcome is always achieved. The usefulness of the integration of guideline recommendations with a reason mechanism capable of handling incomplete information is demonstrated through a case study about the diagnosis of metabolic syndrome.(undefined
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