Promises and Prospects of Microbiome Studies

Since Anthony van Leeuwenhoek, first microscopic observations of the unseen microbiota and the more recent realization that little of the microbes in the biosphere are known, humans have developed a deep curiosity to fully understand the inner workings of the microbial realm. Our ability to characterize the complexity of microbial communities in their natural habitats has dramatically improved over the past decade thanks to advances in high-throughput methodologies. By eliminating the need to isolate and culture individual species, metagenomics approaches have removed many of the obstacles that hindered research in the ecology of mixed microbial consortia, providing valuable information about the diversity, composition, function, and metabolic capability of the community. Microbes are the unseen majority with the capability to colonize every environment, including our bodies. The establishment and composition of a stable human microbiome is determined by the host genetics, immunocompetence, and life-style choices. Our life-style choices determine our exposure to many external and internal environmental factors that permanently or temporarily can influence our microbiome composition. Figure 1 illustrates some of the life-style-related factors that might influence the microbiota of the skin, mouth, and gut. It is not limited to what we carry, touch, breath, and eat. Other dispersal vectors include secretion, excretions, aerosols, air flow, animals, moving surfaces, water, beverages, food, contact, wind, tools, toiletry, and others. These influence the microbiome membership, who are present, and they have the ability to participate in the microbiome dynamic within an environment. The establishment of a microbial community is dependent on many environmental factors, including pH, temperature, altitude, weather, soil type, nutrient availability, relative humidity, air quality, pollutants, microbial competitors, and others. In other words, we are superorganisms interconnected with other living forms on this Earth

What If (Dublin)

Raby developed three ‘What If...’ exhibitions with Dunne (RCA), asking what role design can play in imagining possible futures and raising social, cultural and ethical questions, building on 20 years’ practice in Critical Design theorised inter alia in Dunne and Raby’s Design Noir (2001), Hertzian Tales (2005) and Speculative Everything (2013). Raby’s research included concept development, extended collaboration with exhibitors to develop their contributions, and devising the engagement strategy: all three required localised approaches to audiences, circumstances and commissioning hosts. Extensive investigation was needed in synthetic biology, nanotechnology, surveillance technologies and the domestication of natural phenomena, working with scientific partners at Imperial College and Cambridge University. ‘What If…’ Dublin (2009) comprised 29 projects envisioning hypothetical futures and was reviewed in Irish broadsheets (Examiner, Times, Independent), Wired and New Scientist: ‘the exhibits…address questions on scientific or medical ethics that must be asked in our bio-technological age’ (http://www.newscientist.com/blogs/culturelab/2009/12/post-2.html). Exhibits were also shown at the Art Institute of Chicago, Israel Museum, MoMA and Ars Electronica Center. About 1.8 million people pass the windows of the Wellcome Trust building in London annually, making them an important means of science communication. Wellcome commissioned a changing ‘What If…’ exhibition of 15 themes over 15 months (February 2010 – March 2011). Raby reconceived the design strategy with exhibits engaging at different distances, from passing buses to close-up study. The third exhibition, for the Beijing International Design Triennial (2011), explored the impact on future life of novel technologies through 58 projects in 130 exhibits from 36 designers (12 from China), for a diverse audience. The exhibition and related symposium at Tsinghua University were supported by the British Council. The Triennial was visited by approximately 500,000 visitors and featured widely, e.g. China Central Television, People's Daily, New York Times (all 2011) and Zhuangshi journal (2011 and 2012)

Complexity Theory, Adaptation, and Administrative Law

Recently, commentators have applied insights from complexity theory to legal analysis generally and to administrative law in particular. This Article focuses on one of the central problems that complexity. theory addresses, the importance and mechanisms of adaptation within complex systems. In Part I, the Article uses three features of complex adaptive systems-emergence from self-assembly, nonlinearity, and sensitivity to initial conditions-and explores the extent to which they may add value as a matter of positive analysis to the understanding of change within legal systems. In Part H, the Article focuses on three normative claims in public law scholarship that depend explicitly or implicitly on notions of adaptation: that states offer advantages over the federal government because experimentation can make them more adaptive, that federal agencies should themselves become more experimentalist using the tool of adaptive management, and that administrative agencies shou Id adopt collaborative mechanisms in policymaking. Using two analytic tools found in the complexity literature, the genetic algorithm and evolutionary game theory, the Article tests the extent to which these three normative claims are borne out

Japan's new security agenda

New Japanese Prime Minister Shinzō Abe has only been in office since late September, but already the outlines of his administration are becoming clearer, both in expected and unexpected directions. Abe’s administration is proving to be conservative and revisionist, and even more so than that of his predecessor Junichirō Koizumi. Abe has certainly moved to improve ties with China and South Korea—Beijing and Seoul the October destinations for his first overseas visits within two weeks of taking power—and thereby to limit the damage wrought by Koizumi’s visits to Yasukuni Shrine and bilateral wrangling over Japan’s colonial history. However, the general thrust of Abe’s diplomacy is built upon much of the legacy left by Koizumi, and is attempting to shift it on to a yet more pro-active and assertive path

The Financial Position of Pennsylvania's Public Sector: Past, Present, and Future

This report is the third of three reports that address the fiscal conditions of other states, explores the factors that explain the conditions, and the likely future trends. FRC Report 15