An Unsupervised Approach for Overlapping Cervical Cell Cytoplasm Segmentation

The poor contrast and the overlapping of cervical cell cytoplasm are the major issues in the accurate segmentation of cervical cell cytoplasm. This paper presents an automated unsupervised cytoplasm segmentation approach which can effectively find the cytoplasm boundaries in overlapping cells. The proposed approach first segments the cell clumps from the cervical smear image and detects the nuclei in each cell clump. A modified Otsu method with prior class probability is proposed for accurate segmentation of nuclei from the cell clumps. Using distance regularized level set evolution, the contour around each nucleus is evolved until it reaches the cytoplasm boundaries. Promising results were obtained by experimenting on ISBI 2015 challenge dataset.Comment: 4 pages, 4 figures, Biomedical Engineering and Sciences (IECBES), 2016 IEEE EMBS Conference on. IEEE, 201

Segmentation of Overlapping Cervical Cells in Normal Pap Smear Images Using Distance-Metric and Morphological Operation

The automatic interpretation of Pap Smear image is one of challenging issues in some aspects. Accurate segmentation for each cell is an important procedurethat must be done so that no information is lost during the evaluation process. However, the presence of overlapping cells in Pap Smear image make the automated analysis of these cytology images become more difficult. In most ofthe studies, cytoplasm segmentation is the difficult stage because the boundaries between cells are very thin. In this study, we propose an algorithm that can segment the overlapping cytoplasm. First, the morphology operation and global thresholding to segment cytoplasm is done. Second, the overlapping area on cytoplasm region is separated using morphological operation and distance criteria on each pixel. The proposed method has been evaluated against the results of manual tracing by experts. The experiment results show that the proposed method can segment the overlapping cytoplasm as similar as experts do, i.e., 2:897 3:632 (mean std) using Hausdorff distance

Automatic segmentation of overlapping cervical smear cells based on local distinctive features and guided shape deformation

Automated segmentation of cells from cervical smears poses great challenge to biomedical image analysis because of the noisy and complex background, poor cytoplasmic contrast and the presence of fuzzy and overlapping cells. In this paper, we propose an automated segmentation method for the nucleus and cytoplasm in a cluster of cervical cells based on distinctive local features and guided sparse shape deformation. Our proposed approach is performed in two stages: segmentation of nuclei and cellular clusters, and segmentation of overlapping cytoplasm. In the rst stage, a set of local discriminative shape and appearance cues of image superpixels is incorporated and classi ed by the Support Vector Machine (SVM) to segment the image into nuclei, cellular clusters, and background. In the second stage, a robust shape deformation framework is proposed, based on Sparse Coding (SC) theory and guided by representative shape features, to construct the cytoplasmic shape of each overlapping cell. Then, the obtained shape is re ned by the Distance Regularized Level Set Evolution (DRLSE) model. We evaluated our approach using the ISBI 2014 challenge dataset, which has 135 synthetic cell images for a total of 810 cells. Our results show that our approach outperformed existing approaches in segmenting overlapping cells and obtaining accurate nuclear boundaries. Keywords: overlapping cervical smear cells, feature extraction, sparse coding, shape deformation, distance regularized level set

Deep Learning Techniques for Cervical Cancer Diagnosis based on Pathology and Colposcopy Images

Cervical cancer is a prevalent disease affecting millions of women worldwide every year. It requires significant attention, as early detection during the precancerous stage provides an opportunity for a cure. The screening and diagnosis of cervical cancer rely on cytology and colposcopy methods. Deep learning, a promising technology in computer vision, has emerged as a potential solution to improve the accuracy and efficiency of cervical cancer screening compared to traditional clinical inspection methods that are prone to human error. This review article discusses cervical cancer and its screening processes, followed by the Deep Learning training process and the classification, segmentation, and detection tasks for cervical cancer diagnosis. Additionally, we explored the most common public datasets used in both cytology and colposcopy and highlighted the popular and most utilized architectures that researchers have applied to both cytology and colposcopy. We reviewed 24 selected practical papers in this study and summarized them. This article highlights the remarkable efficiency in enhancing the precision and speed of cervical cancer analysis by Deep Learning, bringing us closer to early diagnosis and saving lives

A Hybrid Linear Iterative Clustering and Bayes Classification-Based GrabCut Segmentation Scheme for Dynamic Detection of Cervical Cancer

Cervical cancer earlier detection remains indispensable for enhancing the survival rate probability among women patients worldwide. The early detection of cervical cancer is done relatively by using the Pap Smear cell Test. This method of detection is challenged by the degradation phenomenon within the image segmentation task that arises when the superpixel count is minimized. This paper introduces a Hybrid Linear Iterative Clustering and Bayes classification-based GrabCut Segmentation Technique (HLC-BC-GCST) for the dynamic detection of Cervical cancer. In this proposed HLC-BC-GCST approach, the Linear Iterative Clustering process is employed to cluster the potential features of the preprocessed image, which is then combined with GrabCut to prevent the issues that arise when the number of superpixels is minimized. In addition, the proposed HLC-BC-GCST scheme benefits of the advantages of the Gaussian mixture model (GMM) on the extracted features from the iterative clustering method, based on which the mapping is performed to describe the energy function. Then, Bayes classification is used for reconstructing the graph cut model from the extracted energy function derived from the GMM model-based Linear Iterative Clustering features for better computation and implementation. Finally, the boundary optimization method is utilized to considerably minimize the roughness of cervical cells, which contains the cytoplasm and nuclei regions, using the GrabCut algorithm to facilitate improved segmentation accuracy. The results of the proposed HLC-BC-GCST scheme are 6% better than the results obtained by other standard detection approaches of cervical cancer using graph cuts