Not Running Wild With the CISG

In determining the boundaries of supranational legislation some courts adopt an expansionist (dynamic) line. To take a well-known regional example, the European Court of Justice (ECJ) has long been engaged in an exercise in expansionist interpretation, thus broadening the scope of European Union legislation at the expense of the political discretion of EU Member States. Though surely seeking to advance what it sees as the Union’s best interests, the ECJ sometimes “runs amok,” actively extending regional rules in ways that constrain national sovereignty beyond what the Members had originally intended. Or, as one of my Copenhagen colleagues  once put it: the ECJ is “running wild.&rdquo

Effect of deuterium on the circadian period and metabolism in wild-type and tau mutant Syrian hamsters

Homozygous tau mutant Syrian hamsters (tau-/-) have a free-running circadian period (τ) around 20 h and a proportionally higher metabolic rate compared with wild-type hamsters (tau+/+) with a period of circa 24 h. In this study, we applied deuterium oxide (D2O) to hamsters to test whether deuteration affects the circadian period of locomotor activity and metabolic rate in both genotypes. Running wheel activity and the metabolic rate were measured in constant illumination before, during, and after administration of 25% deuterium in drinking water. Wild-type hamsters lengthened their circadian period by 1.19 h (SD = 0.29 h) due to D2O application and tau-/- hamsters by 1.20 h (SD = 0.39 h). Deuteration changed neither the amount of activity nor the duration of activity phase (α) in either genotype. The mass specific average metabolic rate (AMR, the oxygen consumption over 24 h) and the mass specific resting metabolic rate (RMR) did not differ during deuteration compared with non-deuteration conditions for either genotype. Both with and without D2O, tau-/- hamsters had higher metabolic rates than tau+/+ hamsters. There was no correlation between changes in the circadian period of locomotor activity and metabolic rates caused by D2O.

Lessons from integrating behaviour and resource selection: activity-specific responses of African wild dogs to roads

Understanding how anthropogenic features affect species' abilities to move within landscapes is essential to conservation planning and requires accurate assessment of resource selection for movement by focal species. Yet, the extent to which an individual's behavioural state (e.g. foraging, resting, commuting) influences resource selection has largely been ignored. Recent advances in Global Positioning System (GPS) tracking technology can fill this gap by associating distinct behavioural states with location data. We investigated the role of behaviour in determining the responses of an endangered species of carnivore, the African wild dog Lycaon pictus, to one of the most widespread forms of landscape alteration globally: road systems. We collected high‐resolution GPS and activity data from 13 wild dogs in northern Botswana over a 2‐year period. We employed a step selection framework to measure resource selection across three behavioural states identified from activity data (high‐speed running, resting and travelling) and across a gradient of habitats and seasons, and compared these outputs to a full model that did not parse for behaviour. The response of wild dogs to roads varied markedly with both the behavioural and the landscape contexts in which roads were encountered. Specifically, wild dogs selected roads when travelling, ignored roads when high‐speed running and avoided roads when resting. This distinction was not evident when all movement data were considered together in the full model. When travelling, selection for roads increased in denser vegetative environments, suggesting that roads may enhance movement for this species. Our findings indicate that including behavioural information in resource selection models is critical to understanding wildlife responses to landscape features and suggest that successful application of resource selection analyses to conservation planning requires explicit examination of the behavioural contexts in which movement occurs. Thus, behaviour‐specific step selection functions offer a powerful tool for identifying resource selection patterns for animal behaviours of conservation significance

Chemotactic properties of Escherichia coli mutants having abnormal Ca2+ content

The calA, calC, and calD mutants of Escherichia coli are known to be sensitive to Ca2+ (R. N. Brey and B. P. Rosen, J. Bacteriol. 139:824-834, 1979). In the absence of any added stimuli for chemotaxis, both the calC and the calD mutants swam with a tumbly bias. Both the calC and the calD mutants were defective in chemotaxis as measured by computer analysis, use of swarm plates, and capillary assays. The calA mutant was only slightly defective in motility and only slightly impaired in chemotaxis. Chemotactically wild-type cells had an intra-cellular free-Ca2+ level of about 105 nM. The intracellular free-Ca2+ levels of the mutants, as determined by use of the fluorescent Ca2+ indicator dye fura-2 or fluo-3, were about 90, about 1,130, and about 410 nM for calA, calC, and calD, respectively. Lowering the intracellular free-Ca2+ levels in wild-type cells and in the tumbly cal mutants by use of Ca2+ chelators promoted running (smooth swimming). Overexpression of CheZ (which causes dephosphorylation of CheY-phosphate) in the wild type and in the tumbly cal mutants decreased the level of tumbliness (which is caused by CheY-phosphate). The calA mutant was 4- to 10-fold more resistant than the wild type to the inhibitory effect of omega-conotoxin on chemotaxis. omega-Conotoxin had no effect on Ca2+ extrusion by wild-type E. coli; that result suggests that omega-conotoxin affects Ca2+ transport at the point of entry instead of exit

"Banks Running Wild--The Subversion of Insurance by "Life Settlements" and Credit Default Swaps"

Oblivious to any lessons that might have been learned from the global financial mess it has created, Wall Street is looking for the next asset bubble. Perhaps in the market for death it has found a replacement for the collapsed markets in subprime mortgage–backed securities and credit default swaps (CDSs). Instead of making bets on the "death" of securities, this new product will allow investors to gamble on the death of human beings by purchasing "life settlements"--life insurance policies that the ill and elderly sell for cash. These policies will then be packaged together as bonds—securitized—and resold to investors, who will receive payouts when the people with the insurance die. In effect, just as the sale of a CDS creates a vested interest in financial calamity, here the act of securitizing life insurance policies creates huge financial incentives in favor of personal calamity. The authors of this Policy Note argue that this is a subversion--or an inversion--of insurance, and it raises important public policy issues: Should we allow the marketing of an instrument in which holders have a financial stake in death? More generally, should we allow the "innovation" of products that condone speculation under the guise of providing insurance?

Uric acid enhances longevity and endurance and protects the brain against ischemia

Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals. Here, we show that male and female mice with UOX haploinsufficiency exhibit an age-related elevation of UA levels, and that the life span of female but not male UOX+/− mice is significantly increased compared to wild-type mice. Serum UA levels are elevated in response to treadmill exercise in UOX+/− mice, but not wild-type mice, and the endurance of the UOX+/− mice is significantly greater than wild-type mice. UOX+/− mice exhibit elevated levels of brain-derived neurotrophic factor, reduced brain damage and improved functional outcome in a model of focal ischemic stroke. Levels of oxidative protein nitration and lipid peroxidation are reduced in muscle and brain tissues of UOX+/− mice under conditions of metabolic and oxidative stress (running in the case of muscle and ischemia in the case of the brain), consistent with prior evidence that UA can scavenge peroxynitrite and hydroxyl radical. Our findings reveal roles for UA in life span determination, endurance and adaptive responses to brain injury, and suggest novel approaches for protecting cells against injury and for optimizing physical performance.España, Ministerio de Educación, Cultura y Deporte EX2009–091

Dingo Destruction 2—Some Hints on Shooting

These articles have been written to assist professional and amateur doggers, as well as farmers, to destroy dingoes or wild dogs (the term wild dogs is generally used to include both dingoes and domestic dogs which are running wild). The information given has been gathered from extensive experience in most of the areas of the State to the south of the Transcontinental railway line

Violencia en Running wild.

This paper aims to shed light, in the light of Lacanian-oriented psychoanalysis, on violence and parricide in the English crime novel "Running wild", highlighting the collectivising character of hatred and the thirst for revenge as the reverse of a senseless paternal law.El presente trabajo aspira a esclarecer a la luz del Psicoanalisis de la Orientacion Lacaniana, la violencia y el parricidio en la novela inglesa de literatura negra “Running wild”, remarcando el carácter colectivizante del odio y de la sed de venganza como reverso de una ley paterna insensata

Different Exercise Tendencies Modulate Behavioral and Molecular Changes to Opioid or Exercise-Induced Reward

Reward changes were observed in rodents with different exercise tendencies by utilizing the conditioned place preference paradigm. Adult male Wistar rats with distinct phenotypes (low volume runners, high volume runners, and wild-type) were given access to a running wheel or an injection of morphine as a rewarding stimulus. There was no difference observed in the strength of conditioned place preference between the rewarding stimuli. Extinction was significantly more effective in low volume runners than high volume runners and wild-type animals, as was observed in the lower percentage of time spent in their assigned conditioning chamber. These findings suggest that low volume runners have a unique underlying genotypic difference, as well as a phenotypic difference from high volume and wild-type runners. It is also suggested that running wheel access and opioid administration are comparable rewarding stimuli in rodents