Infections

• Infections with viruses, bacteria, and macroparasites have been identified as strong risk factors for specific cancers. • Overall, about 2 million (16%) of the total of 12.7 million new cancer cases in 2008 are attributable to infections. This fraction varies 10-fold by region; it is lowest in North America, Australia, and New Zealand (≤ 4%) and highest in sub-Saharan Africa (33%). • Helicobacter pylori, hepatitis B and C viruses, and human papillomaviruses are responsible for 1.9 million cancer cases globally, including mainly gastric, liver, and cervical cancer, respectively. • Infection with HIV substantially increases the risk of virusassociated cancers, through immunosuppression. • Application of existing methods for infection prevention, such as vaccination, safe injection practices, and safe sexual behaviour, or antimicrobial and antiparasite treatments could have a major impact on the future burden of cancer worldwide

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

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