9,173 research outputs found
Joint Modeling and Registration of Cell Populations in Cohorts of High-Dimensional Flow Cytometric Data
In systems biomedicine, an experimenter encounters different potential
sources of variation in data such as individual samples, multiple experimental
conditions, and multi-variable network-level responses. In multiparametric
cytometry, which is often used for analyzing patient samples, such issues are
critical. While computational methods can identify cell populations in
individual samples, without the ability to automatically match them across
samples, it is difficult to compare and characterize the populations in typical
experiments, such as those responding to various stimulations or distinctive of
particular patients or time-points, especially when there are many samples.
Joint Clustering and Matching (JCM) is a multi-level framework for simultaneous
modeling and registration of populations across a cohort. JCM models every
population with a robust multivariate probability distribution. Simultaneously,
JCM fits a random-effects model to construct an overall batch template -- used
for registering populations across samples, and classifying new samples. By
tackling systems-level variation, JCM supports practical biomedical
applications involving large cohorts
FAME: Face Association through Model Evolution
We attack the problem of learning face models for public faces from
weakly-labelled images collected from web through querying a name. The data is
very noisy even after face detection, with several irrelevant faces
corresponding to other people. We propose a novel method, Face Association
through Model Evolution (FAME), that is able to prune the data in an iterative
way, for the face models associated to a name to evolve. The idea is based on
capturing discriminativeness and representativeness of each instance and
eliminating the outliers. The final models are used to classify faces on novel
datasets with possibly different characteristics. On benchmark datasets, our
results are comparable to or better than state-of-the-art studies for the task
of face identification.Comment: Draft version of the stud
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