Better than a lens -- Increasing the signal-to-noise ratio through pupil splitting

Lenses are designed to fulfill Fermats principle such that all light interferes constructively in its focus, guaranteeing its maximum concentration. It can be shown that imaging via an unmodified full pupil yields the maximum transfer strength for all spatial frequencies transferable by the system. Seemingly also the signal-to-noise ratio (SNR) is optimal. The achievable SNR at a given photon budget is critical especially if that budget is strictly limited as in the case of fluorescence microscopy. In this work we propose a general method which achieves a better SNR for high spatial frequency information of an optical imaging system, without the need to capture more photons. This is achieved by splitting the pupil of an incoherent imaging system such that two (or more) sub-images are simultaneously acquired and computationally recombined. We compare the theoretical performance of split pupil imaging to the non-split scenario and implement the splitting using a tilted elliptical mirror placed at the back-focal-plane (BFP) of a fluorescence widefield microscope

Quantifying Uncertainty in High Dimensional Inverse Problems by Convex Optimisation

Inverse problems play a key role in modern image/signal processing methods. However, since they are generally ill-conditioned or ill-posed due to lack of observations, their solutions may have significant intrinsic uncertainty. Analysing and quantifying this uncertainty is very challenging, particularly in high-dimensional problems and problems with non-smooth objective functionals (e.g. sparsity-promoting priors). In this article, a series of strategies to visualise this uncertainty are presented, e.g. highest posterior density credible regions, and local credible intervals (cf. error bars) for individual pixels and superpixels. Our methods support non-smooth priors for inverse problems and can be scaled to high-dimensional settings. Moreover, we present strategies to automatically set regularisation parameters so that the proposed uncertainty quantification (UQ) strategies become much easier to use. Also, different kinds of dictionaries (complete and over-complete) are used to represent the image/signal and their performance in the proposed UQ methodology is investigated.Comment: 5 pages, 5 figure

Revisiting parton evolution and the large-x limit

This remark is part of an ongoing project to simplify the structure of the multi-loop anomalous dimensions for parton distributions and fragmentation functions. It answers the call for a "structural explanation" of a "very suggestive" relation found by Moch, Vermaseren and Vogt in the context of the x->1 behaviour of three-loop DIS anomalous dimensions. It also highlights further structure that remains to be fully explained.Comment: 6 pages, v2 corrects misprints and contains an additional referenc

PURIFY: a new algorithmic framework for next-generation radio-interferometric imaging

In recent works, compressed sensing (CS) and convex opti- mization techniques have been applied to radio-interferometric imaging showing the potential to outperform state-of-the-art imaging algorithms in the field. We review our latest contributions [1, 2, 3], which leverage the versatility of convex optimization to both handle realistic continuous visibilities and offer a highly parallelizable structure paving the way to significant acceleration of the reconstruction and high-dimensional data scalability. The new algorithmic structure promoted in a new software PURIFY (beta version) relies on the simultaneous-direction method of multipliers (SDMM). The performance of various sparsity priors is evaluated through simulations in the continuous visibility setting, confirming the superiority of our recent average sparsity approach SARA

Discriminative Transfer Learning for General Image Restoration

Recently, several discriminative learning approaches have been proposed for effective image restoration, achieving convincing trade-off between image quality and computational efficiency. However, these methods require separate training for each restoration task (e.g., denoising, deblurring, demosaicing) and problem condition (e.g., noise level of input images). This makes it time-consuming and difficult to encompass all tasks and conditions during training. In this paper, we propose a discriminative transfer learning method that incorporates formal proximal optimization and discriminative learning for general image restoration. The method requires a single-pass training and allows for reuse across various problems and conditions while achieving an efficiency comparable to previous discriminative approaches. Furthermore, after being trained, our model can be easily transferred to new likelihood terms to solve untrained tasks, or be combined with existing priors to further improve image restoration quality