Evolutionary Games with Affine Fitness Functions: Applications to Cancer

We analyze the dynamics of evolutionary games in which fitness is defined as an affine function of the expected payoff and a constant contribution. The resulting inhomogeneous replicator equation has an homogeneous equivalent with modified payoffs. The affine terms also influence the stochastic dynamics of a two-strategy Moran model of a finite population. We then apply the affine fitness function in a model for tumor-normal cell interactions to determine which are the most successful tumor strategies. In order to analyze the dynamics of concurrent strategies within a tumor population, we extend the model to a three-strategy game involving distinct tumor cell types as well as normal cells. In this model, interaction with normal cells, in combination with an increased constant fitness, is the most effective way of establishing a population of tumor cells in normal tissue.Comment: The final publication is available at http://www.springerlink.com, http://dx.doi.org/10.1007/s13235-011-0029-

A Way Out of the Quantum Trap

We review Event Enhanced Quantum Theory (EEQT). In Section 1 we address the question "Is Quantum Theory the Last Word". In particular we respond to some of recent challenging staments of H.P. Stapp. We also discuss a possible future of the quantum paradigm - see also Section 5. In Section 2 we give a short sketch of EEQT. Examples are given in Section 3. Section 3.3 discusses a completely new phenomenon - chaos and fractal-like phenomena caused by a simultaneous "measurement" of several non-commuting observables (we include picture of Barnsley's IFS on unit sphere of a Hilbert space). In Section 4 we answer "Frequently Asked Questions" concerning EEQT.Comment: Replacement. Corrected affiliation. Latex, one .jpg figure. To appear in Proc. Conf. Relativistic Quantum Measurements, Napoli 1998, Ed. F. Petruccion

Optical Quantum Computation

We review the field of Optical Quantum Computation, considering the various implementations that have been proposed and the experimental progress that has been made toward realizing them. We examine both linear and nonlinear approaches and both particle and field encodings. In particular we discuss the prospects for large scale optical quantum computing in terms of the most promising physical architectures and the technical requirements for realizing them

A bibliography of research on behavioral decision processes to 1968

Bibliography of research of human behavioral decision making processes to Jan. 196

Stability

Reproducibility is imperative for any scientific discovery. More often than not, modern scientific findings rely on statistical analysis of high-dimensional data. At a minimum, reproducibility manifests itself in stability of statistical results relative to "reasonable" perturbations to data and to the model used. Jacknife, bootstrap, and cross-validation are based on perturbations to data, while robust statistics methods deal with perturbations to models. In this article, a case is made for the importance of stability in statistics. Firstly, we motivate the necessity of stability for interpretable and reliable encoding models from brain fMRI signals. Secondly, we find strong evidence in the literature to demonstrate the central role of stability in statistical inference, such as sensitivity analysis and effect detection. Thirdly, a smoothing parameter selector based on estimation stability (ES), ES-CV, is proposed for Lasso, in order to bring stability to bear on cross-validation (CV). ES-CV is then utilized in the encoding models to reduce the number of predictors by 60% with almost no loss (1.3%) of prediction performance across over 2,000 voxels. Last, a novel "stability" argument is seen to drive new results that shed light on the intriguing interactions between sample to sample variability and heavier tail error distribution (e.g., double-exponential) in high-dimensional regression models with $p$ predictors and $n$ independent samples. In particular, when $p/n\rightarrow\kappa\in(0.3,1)$ and the error distribution is double-exponential, the Ordinary Least Squares (OLS) is a better estimator than the Least Absolute Deviation (LAD) estimator.Comment: Published in at http://dx.doi.org/10.3150/13-BEJSP14 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm

Application and improvement of soil spatial distribution mapping using advanced modelling techniques

The main purpose of this contribution is to develop  realistic prediction digital soil maps in order to increase their visuality, and to evaluate and compare the performance of different modeling techniques: a) Kriging, b) Artificial Neural Network – Multilayer Perceptron (ANN-MLP) and c) Multiple Polynomial Regressions (MPR). The following  criteria were used to determine selection of the testing site for the modeling: (1) intensive metal ore mining and metallurgical processing; (2) geomorphological natural features; (3) regular geological setting, and (4) the remaining minefields. The success of Digital Soil Mapping and the plausibility of prediction maps increases with the availability of spatial data, the availability of computing power for processing data, the development of data-mining tools, geographical information systems (GIS) and numerous applications beyond geostatistics. Advanced prediction modeling techniques, ANN-MLP and MPR include geospatial parameters sourced from Digital Elevation Models (DEM), land use and remote sensing, applied in combination with costly and time-consuming soil measurements, developed and finally incorporated into the models of spatial distribution in the form of 2D or 3D maps. Innovative approaches to modeling assist us in the reconstruction of different processes that impact the entire study area, simultaneously. This holistic approach represents a novelty in contamination mapping and develops prediction models to help in the reconstruction of main distribution pathways, to assess the real size of the affected area as well as improving the data interpretation.</p