1,720 research outputs found
Ammonia production by human faecal bacteria, and the enumeration, isolation and characterization of bacteria capable of growth on peptides and amino acids
DA - 20130125 IS - 1471-2180 (Electronic) IS - 1471-2180 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't SB - IMPeer reviewedPublisher PD
Effectiveness of intervention on physical activity of children: systematic review and meta-analysis of controlled trials with objectively measured outcomes (EarlyBird 54).
addresses: Department of Endocrinology and Metabolism, Peninsula College of Medicine and Dentistry, Plymouth University Campus, Plymouth, UK. [email protected]: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; ReviewCopyright © 2012 by the BMJ Publishing Group Ltd. This articles was first published in: BMJ, 2012, Vol. 345, pp. e5888 -To determine whether, and to what extent, physical activity interventions affect the overall activity levels of children
Clinically confirmed stroke with negative diffusion-weighted imaging magnetic resonance imaging. Longitudinal study of clinical outcomes, stroke recurrence, and systematic review
Makin, Stephen D J Doubal, Fergus N Dennis, Martin S Wardlaw, Joanna M eng 088134/Z/09/A/Wellcome Trust/United Kingdom Observational Study Research Support, Non-U.S. Gov't 2015/10/01 06:00 Stroke. 2015 Nov;46(11):3142-8. doi: 10.1161/STROKEAHA.115.010665. Epub 2015 Sep 29.Peer reviewedPublisher PD
Exposure and Effect Assessment of Aerosolized Red Tide Toxins (Brevetoxins) and Asthma
addresses: National Science Foundation National Institute of Environmental Health Sciences Oceans and Human Health Center, University of Miami Rosenstiel School of Marine and Atmospheric Sciences, Miami, Florida 33136, USA. [email protected]: PMCID: PMC2717136types: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.'Reproduced with permission from Environmental Health Perspectives'Copyright © 2009 National Institute of Environmental Health SciencesIn previous studies we demonstrated statistically significant changes in reported symptoms for lifeguards, general beach goers, and persons with asthma, as well as statistically significant changes in pulmonary function tests (PFTs) in asthmatics, after exposure to brevetoxins in Florida red tide (Karenia brevis bloom) aerosols
The evolution and comparative neurobiology of endocannabinoid signalling
CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol lipase alpha and acts via presynaptic CB(1)-type cannabinoid receptors to inhibit neurotransmitter release. Electrophysiological studies on lampreys indicate that this retrograde signalling mechanism occurs throughout the vertebrates, whereas system-level studies point to conserved roles for endocannabinoid signalling in neural mechanisms of learning and control of locomotor activity and feeding. CB(1)/CB(2)-type receptors originated in a common ancestor of extant chordates, and in the sea squirt Ciona intestinalis a CB(1)/CB(2)-type receptor is targeted to axons, indicative of an ancient role for cannabinoid receptors as axonal regulators of neuronal signalling. Although CB(1)/CB(2)-type receptors are unique to chordates, enzymes involved in biosynthesis/inactivation of endocannabinoids occur throughout the animal kingdom. Accordingly, non-CB(1)/CB(2)-mediated mechanisms of endocannabinoid signalling have been postulated. For example, there is evidence that 2-AG mediates retrograde signalling at synapses in the nervous system of the leech Hirudo medicinalis by activating presynaptic transient receptor potential vanilloid-type ion channels. Thus, postsynaptic synthesis of 2-AG or anandamide may be a phylogenetically widespread phenomenon, and a variety of proteins may have evolved as presynaptic (or postsynaptic) receptors for endocannabinoids
A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron.
Blood. 2005 Oct 15;106(8):2922-3.
A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron.
Porto G, Roetto A, Daraio F, Pinto JP, Almeida S, Bacelar C, Nemeth E, Ganz T, Camaschella C.
PMID: 16204153 [PubMed - indexed for MEDLINE]Free Article
Publication Types, MeSH Terms, SubstancesPublication Types:
Letter
Research Support, Non-U.S. Gov't
MeSH Terms:
Antimicrobial Cationic Peptides/genetics*
Antimicrobial Cationic Peptides/urine
Glycine/genetics*
Hemochromatosis/genetics
Homozygote*
Humans
Iron/pharmacology*
Mutation/genetics
Portugal
Promoter Regions, Genetic/genetics*
Transcription, Genetic/genetics*
Up-Regulation/drug effects*
Substances:
Antimicrobial Cationic Peptides
hepcidin
Glycine
Iron
LinkOut - more resourcesFull Text Sources:
HighWire Press
EBSCO
Other Literature Sources:
COS Scholar Universe
Medical:
Genetics Home Reference - HAMP Gene - Genetics Home Reference
Molecular Biology Databases:
IRON - HSDB
GLYCINE - HSD
Predicting sulfotyrosine sites using the random forest algorithm with significantly improved prediction accuracy
addresses: School of Biosciences, University of Exeter, Exeter EX4 5DE, UK. [email protected]: PMCID: PMC2777180types: Journal Article; Research Support, Non-U.S. Gov't© 2009 Yang; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Tyrosine sulfation is one of the most important posttranslational modifications. Due to its relevance to various disease developments, tyrosine sulfation has become the target for drug design. In order to facilitate efficient drug design, accurate prediction of sulfotyrosine sites is desirable. A predictor published seven years ago has been very successful with claimed prediction accuracy of 98%. However, it has a particularly low sensitivity when predicting sulfotyrosine sites in some newly sequenced proteins
The effectiveness and cost-effectiveness of cochlear implants for severe to profound deafness in children and adults: a systematic review and economic model
addresses: Peninsula Technology Assessment Group (PenTAG), Peninsula Medical School, Universities of Exeter and Plymouth, UK.types: Journal Article; Research Support, Non-U.S. Gov't; ReviewPublished version. Copyright © 2009 NIHR Health Technology Assessment ProgrammeTo investigate whether it is clinically effective and cost-effective to provide (i) a unilateral cochlear implant for severely to profoundly deaf people (using or not using hearing aids), and (ii) a bilateral cochlear implant for severely to profoundly deaf people with a single cochlear implant (unilateral or unilateral plus hearing aid)
- …