ANNODA: tool for integrating molecular-biological annotation data

Collecting, analyzing, and making Molecularbiological annotation data accessible in different public data sources is still an ongoing project. Integration of such data from these data sources might lead to valuable biological knowledge. There are numerous annotation data and only some of those are structured. The number and contents of related sources are continuously increasing. In addition, the existing data sources have their own storage structure and implementation. As a result, these could lead to a limitation in the combining of annotation. Here, we proposed a tool, called ANNODA, for integrating Molecular-biological annotation data. Unlike the past work on database interoperation in the bioinformatics community, this database design uses web-links which are very useful for interactive navigation and meanwhile it also supports automated large-scale analysis tasks. <br /

Facilitating Transformations in a Human Genome Project Database

Human Genome Project databases present a confluence of interesting database challenges: rapid schema and data evolution, complex data entry and constraint management, and the need to integrate multiple data sources and software systems which range over a wide variety of models and formats. While these challenges are not necessarily unique to biological databases, their combination, intensity and complexity are unusual and make automated solutions imperative. We illustrate these problems in the context of the Human Genome Database for Chromosome 22 (Chr22DB), and describe a new approach to a solution for these problems, by means of a deductive language for expressing database transformations and constraints